CRCGN015_MCF10A_48H:H19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description estradiol 104.34 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

188 genes differentially expressed following the CRCGN015_MCF10A_48H:H19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WIF1 WNT inhibitory factor 1 4.45387
CCND3 cyclin D3 4.16917
ZNF586 zinc finger protein 586 3.7582
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 3.63767
DUSP6 dual specificity phosphatase 6 3.2222
GRN granulin 3.11425
SQSTM1 sequestosome 1 3.11219
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.01388
PRAF2 PRA1 domain family, member 2 2.9789
MUC1 mucin 1, cell surface associated 2.88704
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.8071
MALT1 MALT1 paracaspase 2.76259
EPN2 epsin 2 2.73837
CDPF1 cysteine-rich, DPF motif domain containing 1 2.71508
BASP1 brain abundant, membrane attached signal protein 1 2.68514
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 2.60596
IER3 immediate early response 3 2.57018
SKIC2 SKI2 subunit of superkiller complex 2.54419
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.53398
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.50661
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 2.48876
HSPA1A heat shock 70kDa protein 1A 2.44793
GDI1 GDP dissociation inhibitor 1 2.43518
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.43397
SCARA3 scavenger receptor class A, member 3 2.39373
FHL2 four and a half LIM domains 2 2.36521
KLHL21 kelch-like family member 21 2.35959
JUN jun proto-oncogene 2.3514
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.35116
DIXDC1 DIX domain containing 1 2.34685
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.34011
KIFBP kinesin family binding protein 2.33317
SEC61G Sec61 gamma subunit 2.32067
MAGED1 melanoma antigen family D1 2.3177
KEAP1 kelch-like ECH-associated protein 1 2.31253
PLA2G15 phospholipase A2, group XV 2.30131
ATXN2 ataxin 2 2.29996
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2.29013
TSPOAP1 TSPO associated protein 1 2.28479
SLC30A1 solute carrier family 30 (zinc transporter), member 1 2.27177
VAT1 vesicle amine transport 1 2.23944
MLPH melanophilin 2.23656
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 2.22439
KCTD5 potassium channel tetramerization domain containing 5 2.22385
RPN1 ribophorin I 2.22164
PDLIM4 PDZ and LIM domain 4 2.22018
NRIP1 nuclear receptor interacting protein 1 2.21466
SCCPDH saccharopine dehydrogenase (putative) 2.21418
RPAP3 RNA polymerase II associated protein 3 2.20652
EHD1 EH-domain containing 1 2.15058
CHD8 chromodomain helicase DNA binding protein 8 2.14715
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 2.13665
STYXL1 serine/threonine/tyrosine interacting-like 1 2.12203
TAC4 tachykinin 4 (hemokinin) 2.12005
SUSD6 sushi domain containing 6 2.11146
SOX4 SRY (sex determining region Y)-box 4 2.11094
PYGL phosphorylase, glycogen, liver 2.09861
BATF basic leucine zipper transcription factor, ATF-like 2.09628
EGR1 early growth response 1 2.07975
RBKS ribokinase 2.07189
BAMBI BMP and activin membrane-bound inhibitor 2.0713
LRP10 low density lipoprotein receptor-related protein 10 2.06115
EAPP E2F-associated phosphoprotein 2.05848
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.05632
YY1AP1 YY1 associated protein 1 2.05586
FAM114A1 family with sequence similarity 114, member A1 2.03526
GOLGA3 golgin A3 2.02551
TMEM87A transmembrane protein 87A 2.02307
NAGK N-acetylglucosamine kinase 2.00336

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -5.87185
CDK4 cyclin-dependent kinase 4 -3.98196
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.95226
MELK maternal embryonic leucine zipper kinase -3.76924
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.75077
NCK1 NCK adaptor protein 1 -3.71891
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -3.50086
PRR15L proline rich 15-like -3.32137
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -3.27936
ZDHHC6 zinc finger, DHHC-type containing 6 -3.27628
ANAPC1 anaphase promoting complex subunit 1 -3.16209
CNBP CCHC-type zinc finger, nucleic acid binding protein -3.156
WDR12 WD repeat domain 12 -3.14708
ABHD10 abhydrolase domain containing 10 -2.93537
FBXO17 F-box protein 17 -2.89328
ARMC7 armadillo repeat containing 7 -2.79526
S100A8 S100 calcium binding protein A8 -2.73712
VIM vimentin -2.73712
TWNK twinkle mtDNA helicase -2.69125
AURKB aurora kinase B -2.61309
GPHN gephyrin -2.60457
TSPAN4 tetraspanin 4 -2.58077
PYDC1 PYD (pyrin domain) containing 1 -2.57798
EMCN endomucin -2.56245
KIF15 kinesin family member 15 -2.54065
TUBA1C tubulin, alpha 1c -2.51217
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) -2.50614
AHCY adenosylhomocysteinase -2.5046
ASF1B anti-silencing function 1B histone chaperone -2.49468
MRPS22 mitochondrial ribosomal protein S22 -2.48942
LDHD lactate dehydrogenase D -2.48648
PLS1 plastin 1 -2.48135
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa -2.47691
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) -2.46024
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) -2.45431
HMGB2 high mobility group box 2 -2.44733
DYNLT3 dynein, light chain, Tctex-type 3 -2.44129
UMOD uromodulin -2.4408
FXYD1 FXYD domain containing ion transport regulator 1 -2.43956
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 -2.43622
HOXB9 homeobox B9 -2.41225
HMG20B high mobility group 20B -2.41131
HEATR1 HEAT repeat containing 1 -2.40754
TUBA1B tubulin, alpha 1b -2.39814
EML4 echinoderm microtubule associated protein like 4 -2.39756
CDK1 cyclin-dependent kinase 1 -2.37185
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 -2.37015
HADH hydroxyacyl-CoA dehydrogenase -2.33979
CALM2 calmodulin 2 (phosphorylase kinase, delta) -2.32072
UTRN utrophin -2.31694
CCNA2 cyclin A2 -2.31297
NUP205 nucleoporin 205kDa -2.31027
MTREX Mtr4 exosome RNA helicase -2.30808
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent -2.3061
SMNDC1 survival motor neuron domain containing 1 -2.30362
CREG1 cellular repressor of E1A-stimulated genes 1 -2.29576
CDC25B cell division cycle 25B -2.29307
FOXRED2 FAD-dependent oxidoreductase domain containing 2 -2.28745
PTCD3 pentatricopeptide repeat domain 3 -2.28682
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B -2.2729
CLCNKA chloride channel, voltage-sensitive Ka -2.27198
SLC2A4RG SLC2A4 regulator -2.26377
PRELID3B PRELI domain containing 3B -2.25858
MIS18A MIS18 kinetochore protein A -2.25705
PUM3 pumilio RNA binding family member 3 -2.25481
RUVBL1 RuvB-like AAA ATPase 1 -2.24291
PCCB propionyl CoA carboxylase, beta polypeptide -2.23601
FBL fibrillarin -2.23539
ELOVL6 ELOVL fatty acid elongase 6 -2.23175
ADGRE3 adhesion G protein-coupled receptor E3 -2.23104
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -2.22144
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) -2.21318
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) -2.20608
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.19835
BIRC5 baculoviral IAP repeat containing 5 -2.19413
TSC22D3 TSC22 domain family, member 3 -2.17836
CD96 CD96 molecule -2.17469
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -2.17243
MEOX2 mesenchyme homeobox 2 -2.15962
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor -2.15698
KIF18B kinesin family member 18B -2.13382
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.12872
CCNB2 cyclin B2 -2.12603
FHL5 four and a half LIM domains 5 -2.12589
DDN dendrin -2.12357
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.10164
PSRC1 proline/serine-rich coiled-coil 1 -2.09504
NR2C2 nuclear receptor subfamily 2, group C, member 2 -2.09239
SFRP5 secreted frizzled-related protein 5 -2.09033
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.08305
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough -2.073
ABT1 activator of basal transcription 1 -2.06933
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 -2.06493
UBE2C ubiquitin-conjugating enzyme E2C -2.06077
CD34 CD34 molecule -2.05626
TCTA T-cell leukemia translocation altered -2.05599
EBF2 early B-cell factor 2 -2.05584
TMSB10 thymosin beta 10 -2.05457
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 -2.05002
PTMA prothymosin, alpha -2.04938
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) -2.04641
NR2F1 nuclear receptor subfamily 2, group F, member 1 -2.03496
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 -2.03279
SYTL2 synaptotagmin-like 2 -2.031
UXT ubiquitously-expressed, prefoldin-like chaperone -2.03087
PDK4 pyruvate dehydrogenase kinase, isozyme 4 -2.02889
ITM2A integral membrane protein 2A -2.0282
NUP107 nucleoporin 107kDa -2.02693
MAB21L1 mab-21-like 1 (C. elegans) -2.02552
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -2.0254
GPR88 G protein-coupled receptor 88 -2.02255
ZFHX4 zinc finger homeobox 4 -2.02032
NDC1 NDC1 transmembrane nucleoporin -2.01935
FOXM1 forkhead box M1 -2.01928
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.01548
SNRPE small nuclear ribonucleoprotein polypeptide E -2.01147
LOC128966622 putative protein N-methyltransferase FAM86B2 -2.01009
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 -2.00166
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like -2.00116