CRCGN015_MCF10A_48H:I07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenformin 100.46 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

72 genes differentially expressed following the CRCGN015_MCF10A_48H:I07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 3.66367
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 3.54932
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.06427
NLRP4 NLR family, pyrin domain containing 4 3.03822
DLK1 delta-like 1 homolog (Drosophila) 2.78862
MICALL1 MICAL-like 1 2.78226
MAP2K5 mitogen-activated protein kinase kinase 5 2.76355
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.74625
ABHD4 abhydrolase domain containing 4 2.70593
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 2.54692
LOXL1 lysyl oxidase-like 1 2.51403
KYAT1 kynurenine aminotransferase 1 2.46991
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.40821
PYGB phosphorylase, glycogen; brain 2.40267
DUSP6 dual specificity phosphatase 6 2.36818
HMGA2 high mobility group AT-hook 2 2.33805
HAUS4 HAUS augmin-like complex, subunit 4 2.32453
IL33 interleukin 33 2.30749
CAPRIN2 caprin family member 2 2.26137
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 2.2286
CCNH cyclin H 2.2077
HLTF helicase-like transcription factor 2.18422
RRAS related RAS viral (r-ras) oncogene homolog 2.09262
NAP1L3 nucleosome assembly protein 1-like 3 2.07572
TTC31 tetratricopeptide repeat domain 31 2.02409
ACOT13 acyl-CoA thioesterase 13 2.02111
EGR1 early growth response 1 2.00891

decreased expression

Symbol Name Standardized Value
HEATR1 HEAT repeat containing 1 -5.86651
ANXA3 annexin A3 -3.64568
VDAC1 voltage-dependent anion channel 1 -3.62153
DUSP14 dual specificity phosphatase 14 -3.22789
PLK2 polo-like kinase 2 -2.99024
ZDHHC6 zinc finger, DHHC-type containing 6 -2.95979
TXNDC9 thioredoxin domain containing 9 -2.89945
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.74836
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) -2.71475
ZMPSTE24 zinc metallopeptidase STE24 -2.67305
NFIL3 nuclear factor, interleukin 3 regulated -2.53117
PLK1 polo-like kinase 1 -2.51749
GRWD1 glutamate-rich WD repeat containing 1 -2.50594
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.45778
RSU1 Ras suppressor protein 1 -2.42806
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.41512
ZNF35 zinc finger protein 35 -2.38237
LZTFL1 leucine zipper transcription factor-like 1 -2.37284
ASB6 ankyrin repeat and SOCS box containing 6 -2.32169
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 -2.31674
POLR3B polymerase (RNA) III (DNA directed) polypeptide B -2.28695
SLC61A1 solute carrier family 61 member 1 -2.27568
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 -2.23955
PRPF31 pre-mRNA processing factor 31 -2.18635
ABRAXAS2 abraxas 2, BRISC complex subunit -2.16904
PRDM4 PR domain containing 4 -2.16461
CEMIP2 cell migration inducing hyaluronidase 2 -2.16212
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.13948
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.12668
HARS1 histidyl-tRNA synthetase 1 -2.11204
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 -2.10527
OBI1 ORC ubiquitin ligase 1 -2.09361
NLRP2B NLR family pyrin domain containing 2B -2.09333
SPAG1 sperm associated antigen 1 -2.08721
SKP1 S-phase kinase-associated protein 1 -2.08577
PDF peptide deformylase (mitochondrial) -2.08353
BAG1 BCL2-associated athanogene -2.07962
TFB2M transcription factor B2, mitochondrial -2.06957
EAPP E2F-associated phosphoprotein -2.05491
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 -2.04213
CLTB clathrin, light chain B -2.03391
SLC25A46 solute carrier family 25, member 46 -2.03055
TUBA4B tubulin, alpha 4b -2.02377
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa -2.00763
EIF6 eukaryotic translation initiation factor 6 -2.00589