CRCGN015_MCF10A_48H:I08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenformin 33.49 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN015_MCF10A_48H:I08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNPY3 canopy FGF signaling regulator 3 2.92986
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.66395
PRKCH protein kinase C, eta 2.60161
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 2.58333
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.53901
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.43344
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.37426
HAUS4 HAUS augmin-like complex, subunit 4 2.20255
ACAA1 acetyl-CoA acyltransferase 1 2.16898
GALE UDP-galactose-4-epimerase 2.15512
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 2.1042
SCRN1 secernin 1 2.06368
NLRP4 NLR family, pyrin domain containing 4 2.06052
BLMH bleomycin hydrolase 2.05527
EGR1 early growth response 1 2.01579
PABPC1 poly(A) binding protein, cytoplasmic 1 2.00138

decreased expression

Symbol Name Standardized Value
CD24 CD24 molecule -3.6536
NCK1 NCK adaptor protein 1 -3.51928
FAM13B family with sequence similarity 13, member B -2.69327
SLC35F2 solute carrier family 35, member F2 -2.63774
ANKRD10 ankyrin repeat domain 10 -2.49772
ZNF668 zinc finger protein 668 -2.46146
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.37721
SNIP1 Smad nuclear interacting protein 1 -2.33484
FASTKD5 FAST kinase domains 5 -2.2562
NECTIN3 nectin cell adhesion molecule 3 -2.18266
CEMIP2 cell migration inducing hyaluronidase 2 -2.17171
TRIM36 tripartite motif containing 36 -2.15879
STAT1 signal transducer and activator of transcription 1, 91kDa -2.02222