CRCGN015_MCF10A_48H:I13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description toluene diisocyanate 101.79 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

21 genes differentially expressed following the CRCGN015_MCF10A_48H:I13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SMIM40 small integral membrane protein 40 3.13259
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 2.89735
WIF1 WNT inhibitory factor 1 2.89465
MEF2C myocyte enhancer factor 2C 2.72654
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 2.21811
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.05886
INSIG1 insulin induced gene 1 2.0548
FHL2 four and a half LIM domains 2 2.05193
GABARAP GABA(A) receptor-associated protein 2.05115

decreased expression

Symbol Name Standardized Value
MELK maternal embryonic leucine zipper kinase -3.92428
SNX7 sorting nexin 7 -3.46273
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.91259
EIF5 eukaryotic translation initiation factor 5 -2.88244
HEATR1 HEAT repeat containing 1 -2.76745
MKNK1 MAP kinase interacting serine/threonine kinase 1 -2.28204
CHIC2 cysteine-rich hydrophobic domain 2 -2.15164
SPDL1 spindle apparatus coiled-coil protein 1 -2.1298
KRT14 keratin 14, type I -2.12024
OIP5 Opa interacting protein 5 -2.05656
PLK1 polo-like kinase 1 -2.05474
UBE2C ubiquitin-conjugating enzyme E2C -2.01196