CRCGN015_MCF10A_48H:I16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hc yellow 4 99.8 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN015_MCF10A_48H:I16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 3.70644
KDM5A lysine (K)-specific demethylase 5A 3.37556
ARSJ arylsulfatase family, member J 2.5138
ZWINT ZW10 interacting kinetochore protein 2.44401
PDIA5 protein disulfide isomerase family A, member 5 2.4213
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 2.39805
EPN2 epsin 2 2.3977
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 2.24746
SEH1L SEH1-like (S. cerevisiae) 2.12241
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 2.03639
HMGA2 high mobility group AT-hook 2 2.02732

decreased expression

Symbol Name Standardized Value
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -5.87723
MSMO1 methylsterol monooxygenase 1 -5.06503
SLC25A46 solute carrier family 25, member 46 -4.58541
S100A8 S100 calcium binding protein A8 -3.97402
ATG4A autophagy related 4A, cysteine peptidase -3.74194
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.60112
SLC35F2 solute carrier family 35, member F2 -3.34601
DCAF10 DDB1 and CUL4 associated factor 10 -3.02375
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.90072
FOXJ3 forkhead box J3 -2.82393
RAB9A RAB9A, member RAS oncogene family -2.78036
PPID peptidylprolyl isomerase D -2.36872
CREG1 cellular repressor of E1A-stimulated genes 1 -2.35546
FBXO3 F-box protein 3 -2.24553
SMYD3 SET and MYND domain containing 3 -2.23459
MAGT1 magnesium transporter 1 -2.223
STAT1 signal transducer and activator of transcription 1, 91kDa -2.21381
HOOK1 hook microtubule-tethering protein 1 -2.21029
CDHR1 cadherin-related family member 1 -2.18709
INSIG1 insulin induced gene 1 -2.10265
CBR1 carbonyl reductase 1 -2.08345
NME6 NME/NM23 nucleoside diphosphate kinase 6 -2.07758
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -2.07186
CATSPER2 cation channel, sperm associated 2 -2.04727
EPPK1 epiplakin 1 -2.041
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -2.0238