CRCGN015_MCF10A_48H:I19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description thiotepa 98.88 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

25 genes differentially expressed following the CRCGN015_MCF10A_48H:I19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PRKCQ protein kinase C, theta 3.59038
SNX11 sorting nexin 11 3.35212
TLR4 toll-like receptor 4 3.25707
ABHD4 abhydrolase domain containing 4 2.91957
PRKCH protein kinase C, eta 2.89948
CDPF1 cysteine-rich, DPF motif domain containing 1 2.7799
ULBP2 UL16 binding protein 2 2.70882
MVP major vault protein 2.27423
MINDY1 MINDY lysine 48 deubiquitinase 1 2.1823
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 2.12269
AKTIP AKT interacting protein 2.01317
TPD52L1 tumor protein D52-like 1 2.00161

decreased expression

Symbol Name Standardized Value
RPA3 replication protein A3, 14kDa -4.09721
CCNB1 cyclin B1 -3.71665
PUF60 poly-U binding splicing factor 60KDa -3.219
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.83221
VIM vimentin -2.67318
HEATR1 HEAT repeat containing 1 -2.48346
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.4631
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.19005
HMGB2 high mobility group box 2 -2.19001
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.131
RBM22 RNA binding motif protein 22 -2.09796
PSRC1 proline/serine-rich coiled-coil 1 -2.09109
AK6 adenylate kinase 6 -2.05776