CRCGN015_MCF10A_48H:I22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tryptophan 100.97 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

69 genes differentially expressed following the CRCGN015_MCF10A_48H:I22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 4.47011
ABHD6 abhydrolase domain containing 6 3.85927
C2CD2 C2 calcium-dependent domain containing 2 3.62304
VGLL4 vestigial-like family member 4 3.20393
AMDHD2 amidohydrolase domain containing 2 3.06649
BDKRB2 bradykinin receptor B2 2.82537
COL16A1 collagen, type XVI, alpha 1 2.78218
ANO10 anoctamin 10 2.74603
EPN2 epsin 2 2.71488
RAP1GAP RAP1 GTPase activating protein 2.58766
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.50727
KLHL21 kelch-like family member 21 2.47275
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.41579
IER3 immediate early response 3 2.38601
CCNL1 cyclin L1 2.34106
VSTM4 V-set and transmembrane domain containing 4 2.32935
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.3063
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.28328
ZNF706 zinc finger protein 706 2.24114
MORN1 MORN repeat containing 1 2.22037
SQSTM1 sequestosome 1 2.21966
SLC75A1 solute carrier family 75 member 1 2.20846
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 2.20234
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.17648
ARL8B ADP-ribosylation factor-like 8B 2.1685
SYNGR3 synaptogyrin 3 2.15987
GOLGA4 golgin A4 2.11964
EMILIN1 elastin microfibril interfacer 1 2.10364
IL1B interleukin 1, beta 2.09531
UBQLN2 ubiquilin 2 2.06354
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2.05939
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.05028
CNPY4 canopy FGF signaling regulator 4 2.04424
SLC12A8 solute carrier family 12, member 8 2.03769
GPRASP1 G protein-coupled receptor associated sorting protein 1 2.03156
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.02331
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.02074
GPATCH8 G patch domain containing 8 2.01823
KLHL36 kelch-like family member 36 2.00721
MXRA8 matrix-remodelling associated 8 2.00482
FMOD fibromodulin 2.00415

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -4.58627
CDK4 cyclin-dependent kinase 4 -3.70126
PARP2 poly (ADP-ribose) polymerase 2 -3.45359
LYPLA1 lysophospholipase I -3.35623
PLS1 plastin 1 -3.0893
CDC20 cell division cycle 20 -2.59305
MRPL15 mitochondrial ribosomal protein L15 -2.52916
TRIP13 thyroid hormone receptor interactor 13 -2.52356
ASF1B anti-silencing function 1B histone chaperone -2.50309
WWC2 WW and C2 domain containing 2 -2.4315
CAMKMT calmodulin-lysine N-methyltransferase -2.35258
MRPS2 mitochondrial ribosomal protein S2 -2.31312
KIF20A kinesin family member 20A -2.28971
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.27932
CDK1 cyclin-dependent kinase 1 -2.27007
DEPDC1 DEP domain containing 1 -2.26463
BFAR bifunctional apoptosis regulator -2.16781
PARP1 poly (ADP-ribose) polymerase 1 -2.15795
CETP cholesteryl ester transfer protein, plasma -2.15542
ANKRD10 ankyrin repeat domain 10 -2.13994
NFIL3 nuclear factor, interleukin 3 regulated -2.12854
RBBP8 retinoblastoma binding protein 8 -2.07008
TBCE tubulin folding cofactor E -2.04815
CCNB2 cyclin B2 -2.03807
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.02785
ILK integrin-linked kinase -2.02743
FASTKD5 FAST kinase domains 5 -2.02178
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa -2.01261