CRCGN015_MCF10A_48H:J06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vinyl toluene 11.11 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

362 genes differentially expressed following the CRCGN015_MCF10A_48H:J06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD4 abhydrolase domain containing 4 4.94576
AMDHD2 amidohydrolase domain containing 2 4.60554
CDK19 cyclin-dependent kinase 19 4.19722
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.02141
DHDDS dehydrodolichyl diphosphate synthase 3.96896
CCP110 centriolar coiled coil protein 110kDa 3.92683
PRR7 proline rich 7 (synaptic) 3.83047
POMT2 protein-O-mannosyltransferase 2 3.68859
KLHL36 kelch-like family member 36 3.61529
PFKL phosphofructokinase, liver 3.58552
ODF2 outer dense fiber of sperm tails 2 3.50073
CASP10 caspase 10, apoptosis-related cysteine peptidase 3.34695
CRYBB3 crystallin, beta B3 3.33485
KCNIP2 Kv channel interacting protein 2 3.31326
CDHR2 cadherin-related family member 2 3.31149
CDC45 cell division cycle 45 3.28857
CRYBG3 beta-gamma crystallin domain containing 3 3.23828
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 3.21682
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 3.21492
CCDC134 coiled-coil domain containing 134 3.19206
FGF17 fibroblast growth factor 17 3.15787
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.09847
ZBTB32 zinc finger and BTB domain containing 32 3.05051
PRH1 proline-rich protein HaeIII subfamily 1 3.02192
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4 3.00958
BLM Bloom syndrome, RecQ helicase-like 3.00437
SNX11 sorting nexin 11 2.96846
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 2.91813
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 2.91639
MUC3B mucin 3B, cell surface associated 2.8939
CIDEC cell death-inducing DFFA-like effector c 2.88157
HMX1 H6 family homeobox 1 2.86685
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.85586
GNG7 guanine nucleotide binding protein (G protein), gamma 7 2.84856
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 2.84605
LOC107987462 leukocyte immunoglobulin-like receptor subfamily B member 3 2.82171
CCL13 chemokine (C-C motif) ligand 13 2.81579
CPAP centrosome assembly and centriole elongation protein 2.81338
SOCS3 suppressor of cytokine signaling 3 2.79379
CGB8 chorionic gonadotropin, beta polypeptide 8 2.79126
ZNF593 zinc finger protein 593 2.77525
DROSHA drosha, ribonuclease type III 2.76769
ANKRD49 ankyrin repeat domain 49 2.76655
CATSPERH catsper channel auxiliary subunit eta 2.76621
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) 2.76229
PDE9A phosphodiesterase 9A 2.75437
ZBP1 Z-DNA binding protein 1 2.74419
APH1B APH1B gamma secretase subunit 2.69982
PDCD1 programmed cell death 1 2.69879
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 2.69661
EBF2 early B-cell factor 2 2.68915
SNW1 SNW domain containing 1 2.6695
MYBPC3 myosin binding protein C, cardiac 2.66726
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.6548
POU3F2 POU class 3 homeobox 2 2.65437
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.64457
OSGIN1 oxidative stress induced growth inhibitor 1 2.6425
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.63903
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.62151
RIC8B RIC8 guanine nucleotide exchange factor B 2.61732
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 2.60675
DMBT1 deleted in malignant brain tumors 1 2.60528
ITGA7 integrin, alpha 7 2.5924
AMN amnion associated transmembrane protein 2.58841
DUX4 double homeobox 4 2.58722
ASB6 ankyrin repeat and SOCS box containing 6 2.57703
NGB neuroglobin 2.57596
TLX1 T-cell leukemia homeobox 1 2.57049
MINDY1 MINDY lysine 48 deubiquitinase 1 2.56967
ADGRB1 adhesion G protein-coupled receptor B1 2.5666
RGS9BP regulator of G protein signaling 9 binding protein 2.56147
TENT5C terminal nucleotidyltransferase 5C 2.55745
BARX2 BARX homeobox 2 2.55669
MORN1 MORN repeat containing 1 2.55234
PWWP3A PWWP domain containing 3A, DNA repair factor 2.54871
LOC102723996 ICOS ligand 2.53616
GFER growth factor, augmenter of liver regeneration 2.53553
RTEL1 regulator of telomere elongation helicase 1 2.53243
TRAIP TRAF interacting protein 2.52025
ADGRF1 adhesion G protein-coupled receptor F1 2.50183
PTP4A3 protein tyrosine phosphatase type IVA, member 3 2.49929
TRIM9 tripartite motif containing 9 2.48882
GPATCH3 G patch domain containing 3 2.48734
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 2.48353
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 2.48148
PIM2 Pim-2 proto-oncogene, serine/threonine kinase 2.48062
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 2.47855
LHX5 LIM homeobox 5 2.47761
A4GALT alpha 1,4-galactosyltransferase 2.47482
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like 2.47392
NEUROG1 neurogenin 1 2.47202
DOK3 docking protein 3 2.46892
TROAP trophinin associated protein 2.4646
ZNHIT2 zinc finger, HIT-type containing 2 2.45341
TOB1 transducer of ERBB2, 1 2.4505
CNPY4 canopy FGF signaling regulator 4 2.44852
ASXL2 additional sex combs like transcriptional regulator 2 2.43943
CCL1 chemokine (C-C motif) ligand 1 2.43507
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 2.43495
CEND1 cell cycle exit and neuronal differentiation 1 2.43234
TSC22D4 TSC22 domain family, member 4 2.42907
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.4232
MTHFSD methenyltetrahydrofolate synthetase domain containing 2.42302
TPK1 thiamin pyrophosphokinase 1 2.419
MTMR12 myotubularin related protein 12 2.41729
CBX2 chromobox homolog 2 2.41386
EVX1 even-skipped homeobox 1 2.40392
PLCH2 phospholipase C, eta 2 2.40027
ZC2HC1C zinc finger, C2HC-type containing 1C 2.38633
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 2.38233
GUCA1B guanylate cyclase activator 1B (retina) 2.37108
THAP3 THAP domain containing, apoptosis associated protein 3 2.36899
EHMT1 euchromatic histone-lysine N-methyltransferase 1 2.36887
JUND jun D proto-oncogene 2.36405
GRIP2 glutamate receptor interacting protein 2 2.36375
WDR62 WD repeat domain 62 2.36335
CLDN4 claudin 4 2.363
REM1 RAS (RAD and GEM)-like GTP-binding 1 2.35697
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae) 2.35399
ONECUT2 one cut homeobox 2 2.34647
CRY1 cryptochrome circadian clock 1 2.34537
SAMD14 sterile alpha motif domain containing 14 2.34427
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 2.33945
CAPN5 calpain 5 2.33815
HROB homologous recombination factor with OB-fold 2.33799
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 2.33303
SSX5 synovial sarcoma, X breakpoint 5 2.32918
GAST gastrin 2.32331
ZNF205 zinc finger protein 205 2.32222
BATF basic leucine zipper transcription factor, ATF-like 2.31856
LIPT1 lipoyltransferase 1 2.31431
PARVB parvin, beta 2.31411
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 2.3086
APOL6 apolipoprotein L, 6 2.30809
DCLRE1B DNA cross-link repair 1B 2.2983
LEP leptin 2.29646
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.29513
INF2 inverted formin, FH2 and WH2 domain containing 2.29346
MYH13 myosin, heavy chain 13, skeletal muscle 2.28385
HABP4 hyaluronan binding protein 4 2.2821
IL36A interleukin 36, alpha 2.2802
HOXD11 homeobox D11 2.27753
KCNK10 potassium channel, two pore domain subfamily K, member 10 2.275
VRTN vertebrae development associated 2.27439
EXOC3 exocyst complex component 3 2.26873
KCTD17 potassium channel tetramerization domain containing 17 2.26518
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 2.26518
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 2.25831
ODAD2 outer dynein arm docking complex subunit 2 2.25702
MKS1 Meckel syndrome, type 1 2.25586
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.25447
FASTKD1 FAST kinase domains 1 2.24952
ADAP1 ArfGAP with dual PH domains 1 2.24817
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.24701
OXCT2 3-oxoacid CoA transferase 2 2.2468
HOXD10 homeobox D10 2.24659
FER fer (fps/fes related) tyrosine kinase 2.24638
TPPP tubulin polymerization promoting protein 2.2436
SH3BP1 SH3-domain binding protein 1 2.24193
GDF2 growth differentiation factor 2 2.24107
BOLA2B bolA family member 2B 2.23701
LMX1B LIM homeobox transcription factor 1, beta 2.23567
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 2.23396
ABHD11 abhydrolase domain containing 11 2.22809
EPCIP exosomal polycystin 1 interacting protein 2.22665
CLCN2 chloride channel, voltage-sensitive 2 2.22632
CERS1 ceramide synthase 1 2.22295
FAM114A2 family with sequence similarity 114, member A2 2.22281
FAM124B family with sequence similarity 124B 2.21868
PCDHB13 protocadherin beta 13 2.21727
C15ORF38-AP3S2 C15orf38-AP3S2 readthrough 2.2171
EXD3 exonuclease 3'-5' domain containing 3 2.21664
LIME1 Lck interacting transmembrane adaptor 1 2.21483
PRMT7 protein arginine methyltransferase 7 2.21472
BATF3 basic leucine zipper transcription factor, ATF-like 3 2.21439
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 2.21311
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 2.21203
IGFALS insulin-like growth factor binding protein, acid labile subunit 2.20247
FAM110D family with sequence similarity 110, member D 2.20044
ZDHHC11B zinc finger, DHHC-type containing 11B 2.19927
GATD3 glutamine amidotransferase class 1 domain containing 3 2.19804
ARL2BP ADP-ribosylation factor-like 2 binding protein 2.19511
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.19334
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 2.1786
CLSTN2 calsyntenin 2 2.17632
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 2.17523
PRDM8 PR domain containing 8 2.17418
IQSEC3 IQ motif and Sec7 domain 3 2.17367
LIPE lipase, hormone-sensitive 2.17353
ELP4 elongator acetyltransferase complex subunit 4 2.17082
CYTH3 cytohesin 3 2.1676
HBA1 hemoglobin, alpha 1 2.16349
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 2.16314
PCSK5 proprotein convertase subtilisin/kexin type 5 2.16311
GRM4 glutamate receptor, metabotropic 4 2.15799
PRDM1 PR domain containing 1, with ZNF domain 2.15668
CLDN3 claudin 3 2.1555
IQCE IQ motif containing E 2.155
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 2.14957
TXNIP thioredoxin interacting protein 2.14733
GRK1 G protein-coupled receptor kinase 1 2.14467
PTDSS2 phosphatidylserine synthase 2 2.14029
POMT1 protein-O-mannosyltransferase 1 2.13952
PTGES3 prostaglandin E synthase 3 (cytosolic) 2.13447
ZMAT4 zinc finger, matrin-type 4 2.13396
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 2.13344
MATN4 matrilin 4 2.12869
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.12833
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) 2.12827
YJU2 YJU2 splicing factor homolog 2.1249
TUBA1B tubulin, alpha 1b 2.11759
IKZF4 IKAROS family zinc finger 4 (Eos) 2.11676
MYO1A myosin IA 2.11547
GJD2 gap junction protein, delta 2, 36kDa 2.11473
ADISSP adipose secreted signaling protein 2.11346
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like 2.10957
TRNAU1AP tRNA selenocysteine 1 associated protein 1 2.10749
RHOQ ras homolog family member Q 2.10738
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 2.10717
RFX1 regulatory factor X, 1 (influences HLA class II expression) 2.10706
GPR88 G protein-coupled receptor 88 2.10655
DNAH9 dynein, axonemal, heavy chain 9 2.1058
GLRX2 glutaredoxin 2 2.10542
FAM120C family with sequence similarity 120C 2.10514
EXO1 exonuclease 1 2.10507
TBCCD1 TBCC domain containing 1 2.09998
PHF7 PHD finger protein 7 2.0997
AZIN2 antizyme inhibitor 2 2.09882
RAB40C RAB40C, member RAS oncogene family 2.09786
SCTR secretin receptor 2.09646
CPNE7 copine VII 2.09398
REG3A regenerating islet-derived 3 alpha 2.09256
CFAP410 cilia and flagella associated protein 410 2.0925
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G 2.08706
OR10H1 olfactory receptor, family 10, subfamily H, member 1 2.08276
POT1 protection of telomeres 1 2.08137
TRMT61A tRNA methyltransferase 61A 2.07948
HAAO 3-hydroxyanthranilate 3,4-dioxygenase 2.07943
ZNF428 zinc finger protein 428 2.07352
AIRE autoimmune regulator 2.0729
MED16 mediator complex subunit 16 2.07219
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 2.07064
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa 2.07035
ATP5IF1 ATP synthase inhibitory factor subunit 1 2.06832
ATXN7L1 ataxin 7-like 1 2.06701
EDA2R ectodysplasin A2 receptor 2.06582
DBR1 debranching RNA lariats 1 2.06523
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.06513
DAPK3 death-associated protein kinase 3 2.06435
CD40LG CD40 ligand 2.06184
TMEM120B transmembrane protein 120B 2.05925
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 2.05828
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 2.05582
MXRA8 matrix-remodelling associated 8 2.05563
OSBPL7 oxysterol binding protein-like 7 2.05203
ERI3 ERI1 exoribonuclease family member 3 2.05125
IFNAR2 interferon (alpha, beta and omega) receptor 2 2.04623
ADM2 adrenomedullin 2 2.04566
FBXO40 F-box protein 40 2.04417
GPR31 G protein-coupled receptor 31 2.04287
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 2.04182
DNTT DNA nucleotidylexotransferase 2.03766
PKD2L1 polycystic kidney disease 2-like 1 2.03745
OGFRL1 opioid growth factor receptor-like 1 2.03662
ZC2HC1A zinc finger, C2HC-type containing 1A 2.03504
MNMIP1 manchette microtubule inner protein 1 2.03358
NDOR1 NADPH dependent diflavin oxidoreductase 1 2.0269
OLA1 Obg-like ATPase 1 2.02679
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.02588
DGKG diacylglycerol kinase, gamma 90kDa 2.02514
DLX6 distal-less homeobox 6 2.02446
DEPP1 DEPP autophagy regulator 1 2.02285
PYCR3 pyrroline-5-carboxylate reductase 3 2.02275
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 2.02206
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1 2.01728
NPAS1 neuronal PAS domain protein 1 2.01693
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2.01669
RNASE12 ribonuclease, RNase A family, 12 (non-active) 2.01571
ZNF688 zinc finger protein 688 2.01356
SRBD1 S1 RNA binding domain 1 2.01152
PACS2 phosphofurin acidic cluster sorting protein 2 2.01087
NT5C 5', 3'-nucleotidase, cytosolic 2.00896
LTC4S leukotriene C4 synthase 2.00644
AGFG2 ArfGAP with FG repeats 2 2.00114
TP53TG5 TP53 target 5 2.0009

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -6.58925
PGAM4 phosphoglycerate mutase family member 4 -5.14882
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -5.04911
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.6266
FN1 fibronectin 1 -4.09757
MSMO1 methylsterol monooxygenase 1 -4.05278
OXA1L oxidase (cytochrome c) assembly 1-like -4.01409
SCYL3 SCY1-like 3 (S. cerevisiae) -3.66773
GMPR2 guanosine monophosphate reductase 2 -3.24545
PRPF19 pre-mRNA processing factor 19 -3.21674
KRT7 keratin 7, type II -3.102
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -3.03922
RPN2 ribophorin II -3.02313
ARL2 ADP-ribosylation factor-like 2 -2.984
CTNND1 catenin (cadherin-associated protein), delta 1 -2.84852
LOC124907782 dual specificity protein phosphatase 22 -2.83058
RABGGTB Rab geranylgeranyltransferase, beta subunit -2.745
VSNL1 visinin-like 1 -2.70621
CTBS chitobiase, di-N-acetyl- -2.70256
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 -2.63591
KRT17 keratin 17, type I -2.60238
ANXA8L1 annexin A8-like 1 -2.53494
BEX3 brain expressed X-linked 3 -2.52878
GNG5 guanine nucleotide binding protein (G protein), gamma 5 -2.51506
MALT1 MALT1 paracaspase -2.48854
PDIA3 protein disulfide isomerase family A, member 3 -2.48821
GHITM growth hormone inducible transmembrane protein -2.47858
ZNF91 zinc finger protein 91 -2.37931
TEX10 testis expressed 10 -2.36979
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 -2.3673
NDN necdin, melanoma antigen (MAGE) family member -2.36553
RGS18 regulator of G-protein signaling 18 -2.36537
NINJ1 ninjurin 1 -2.3632
BCL6 B-cell CLL/lymphoma 6 -2.36008
ZMIZ1 zinc finger, MIZ-type containing 1 -2.35364
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -2.32485
DDB1 damage-specific DNA binding protein 1, 127kDa -2.32092
TIMP1 TIMP metallopeptidase inhibitor 1 -2.31909
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) -2.28037
RPL28 ribosomal protein L28 -2.27173
PGK1 phosphoglycerate kinase 1 -2.2706
SF3B2 splicing factor 3b, subunit 2, 145kDa -2.26772
KIF20A kinesin family member 20A -2.25781
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.2532
EREG epiregulin -2.24895
EMC7 ER membrane protein complex subunit 7 -2.2469
EIF4H eukaryotic translation initiation factor 4H -2.24113
VKORC1 vitamin K epoxide reductase complex, subunit 1 -2.23341
REL v-rel avian reticuloendotheliosis viral oncogene homolog -2.20939
GJA1 gap junction protein, alpha 1, 43kDa -2.19666
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 -2.18576
QARS1 glutaminyl-tRNA synthetase 1 -2.16699
CYFIP1 cytoplasmic FMR1 interacting protein 1 -2.16047
NNMT nicotinamide N-methyltransferase -2.14875
STK26 serine/threonine protein kinase 26 -2.14726
CSNK2B casein kinase 2, beta polypeptide -2.14529
RAP2C RAP2C, member of RAS oncogene family -2.14027
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -2.1302
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.12545
H2AZ1 H2A.Z variant histone 1 -2.12494
PRPS2 phosphoribosyl pyrophosphate synthetase 2 -2.08931
GPR87 G protein-coupled receptor 87 -2.07823
APMAP adipocyte plasma membrane associated protein -2.07344
GRN granulin -2.07291
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -2.07
NIPAL2 NIPA-like domain containing 2 -2.05931
TM2D1 TM2 domain containing 1 -2.04977
CXCL13 chemokine (C-X-C motif) ligand 13 -2.04208
IFITM3 interferon induced transmembrane protein 3 -2.03741
CYB5A cytochrome b5 type A (microsomal) -2.03408
MRPL49 mitochondrial ribosomal protein L49 -2.03386
USP11 ubiquitin specific peptidase 11 -2.03374
S100A2 S100 calcium binding protein A2 -2.02846
P3H2 prolyl 3-hydroxylase 2 -2.02694
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -2.01936
LOC114841035 uncharacterized LOC114841035 -2.01454
PKM pyruvate kinase, muscle -2.00948