CRCGN015_MCF10A_48H:J11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tretinoin 33.43 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN015_MCF10A_48H:J11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 4.23043
FHL2 four and a half LIM domains 2 3.88589
HOXA5 homeobox A5 3.77553
STAP2 signal transducing adaptor family member 2 3.76336
MYLK myosin light chain kinase 3.67181
MYL9 myosin, light chain 9, regulatory 3.37357
PDLIM1 PDZ and LIM domain 1 2.98192
RSF1 remodeling and spacing factor 1 2.52401
DSG2 desmoglein 2 2.45669
ELOVL6 ELOVL fatty acid elongase 6 2.40568
HOXA7 homeobox A7 2.34287
ALDOC aldolase C, fructose-bisphosphate 2.32656
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.30494
TGFB1I1 transforming growth factor beta 1 induced transcript 1 2.28641
PKN1 protein kinase N1 2.19846
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.18721
DUSP4 dual specificity phosphatase 4 2.17986
APOL6 apolipoprotein L, 6 2.17494
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.13978
TPM1 tropomyosin 1 (alpha) 2.13323
CTSB cathepsin B 2.08312
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.0824
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 2.04696
LGALS9C lectin, galactoside-binding, soluble, 9C 2.04613
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.02966
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.02622
EPHB2 EPH receptor B2 2.01558
HOXA10 homeobox A10 2.0073

decreased expression

Symbol Name Standardized Value
RGS2 regulator of G-protein signaling 2 -4.842
KRT14 keratin 14, type I -4.04905
S100A8 S100 calcium binding protein A8 -3.59358
DYNLT3 dynein, light chain, Tctex-type 3 -2.92432
CDC25B cell division cycle 25B -2.91393
TCEAL4 transcription elongation factor A (SII)-like 4 -2.84319
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -2.76816
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.60081
JMJD6 jumonji domain containing 6 -2.60025
CTSD cathepsin D -2.51499
GFUS GDP-L-fucose synthase -2.32966
BAG3 BCL2-associated athanogene 3 -2.31522
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -2.27129
PRODH proline dehydrogenase (oxidase) 1 -2.25003
ILF2 interleukin enhancer binding factor 2 -2.24606
TRNAU1AP tRNA selenocysteine 1 associated protein 1 -2.22459
HMGA2 high mobility group AT-hook 2 -2.17463
PMVK phosphomevalonate kinase -2.15569
SETD1A SET domain containing 1A -2.14331
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -2.11654
S100A4 S100 calcium binding protein A4 -2.10217
AMZ2 archaelysin family metallopeptidase 2 -2.08516
ETFB electron-transfer-flavoprotein, beta polypeptide -2.07207
RYR1 ryanodine receptor 1 (skeletal) -2.05949
LORICRIN loricrin cornified envelope precursor protein -2.04621
BAALC brain and acute leukemia, cytoplasmic -2.0461
EFNA3 ephrin-A3 -2.03677
PER1 period circadian clock 1 -2.00292