CRCGN015_MCF10A_48H:J12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tretinoin 11.14 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

69 genes differentially expressed following the CRCGN015_MCF10A_48H:J12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYL9 myosin, light chain 9, regulatory 4.78187
HOXA5 homeobox A5 3.88003
FHL2 four and a half LIM domains 2 3.81822
FPGS folylpolyglutamate synthase 2.85581
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.814
DSG2 desmoglein 2 2.68672
ALDOC aldolase C, fructose-bisphosphate 2.52999
BAG3 BCL2-associated athanogene 3 2.35536
PHF2 PHD finger protein 2 2.30137
STIMATE STIM activating enhancer 2.26911
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.22854
GMIP GEM interacting protein 2.18641
ELOVL6 ELOVL fatty acid elongase 6 2.18044
ERBIN erbb2 interacting protein 2.17581
HOXA7 homeobox A7 2.17292
SERINC5 serine incorporator 5 2.07116
TPM1 tropomyosin 1 (alpha) 2.06444
CORO1C coronin, actin binding protein, 1C 2.06164
JARID2 jumonji, AT rich interactive domain 2 2.05987
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 2.05872
SEPTIN8 septin 8 2.05695

decreased expression

Symbol Name Standardized Value
RGS2 regulator of G-protein signaling 2 -5.35723
S100A8 S100 calcium binding protein A8 -4.82959
STAT1 signal transducer and activator of transcription 1, 91kDa -3.89245
KRT14 keratin 14, type I -3.84956
NGRN neugrin, neurite outgrowth associated -3.15434
NCK1 NCK adaptor protein 1 -3.10784
CSRP2 cysteine and glycine-rich protein 2 -3.06167
RECQL RecQ helicase-like -3.03986
DYNLT3 dynein, light chain, Tctex-type 3 -2.96065
ALOX12B arachidonate 12-lipoxygenase, 12R type -2.82884
GOLT1B golgi transport 1B -2.76265
HMGA2 high mobility group AT-hook 2 -2.74611
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.63398
SPX spexin hormone -2.61169
ALOXE3 arachidonate lipoxygenase 3 -2.46251
KLK11 kallikrein-related peptidase 11 -2.38144
ARID5B AT rich interactive domain 5B (MRF1-like) -2.38025
AADAC arylacetamide deacetylase -2.3691
MMP3 matrix metallopeptidase 3 -2.32474
LY6G6C lymphocyte antigen 6 complex, locus G6C -2.31789
LCE2B late cornified envelope 2B -2.31217
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.2501
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -2.24444
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.24308
LDHB lactate dehydrogenase B -2.22895
YIPF4 Yip1 domain family, member 4 -2.22032
NLRP4 NLR family, pyrin domain containing 4 -2.2096
CPA2 carboxypeptidase A2 (pancreatic) -2.20893
CDKL3 cyclin-dependent kinase-like 3 -2.19232
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -2.17314
CTRB1 chymotrypsinogen B1 -2.16405
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.16389
S100A4 S100 calcium binding protein A4 -2.16259
ORC3 origin recognition complex, subunit 3 -2.12097
NTSR1 neurotensin receptor 1 (high affinity) -2.11126
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 -2.10552
WNT16 wingless-type MMTV integration site family, member 16 -2.10079
MT2A metallothionein 2A -2.10062
AKAP3 A kinase (PRKA) anchor protein 3 -2.07878
RARS1 arginyl-tRNA synthetase 1 -2.0689
IAPP islet amyloid polypeptide -2.06772
KANSL1L KAT8 regulatory NSL complex subunit 1-like -2.05859
ING4 inhibitor of growth family, member 4 -2.05832
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.05001
REXO5 RNA exonuclease 5 -2.03307
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -2.01996
CDSN corneodesmosin -2.01818
CTRL chymotrypsin-like -2.00744