CRCGN015_MCF10A_48H:J17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-(1-naphthyl)ethylenediamine.2hcl 33.66 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

148 genes differentially expressed following the CRCGN015_MCF10A_48H:J17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 4.49658
SQSTM1 sequestosome 1 4.1293
IER3 immediate early response 3 3.73374
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.60561
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 3.43921
PNKP polynucleotide kinase 3'-phosphatase 3.43345
ADGRE5 adhesion G protein-coupled receptor E5 3.13319
DUSP4 dual specificity phosphatase 4 3.13158
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 2.98559
VAT1 vesicle amine transport 1 2.96229
HMOX1 heme oxygenase 1 2.95281
SNX11 sorting nexin 11 2.9431
MVP major vault protein 2.83032
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.72456
LRP10 low density lipoprotein receptor-related protein 10 2.68299
SLC61A1 solute carrier family 61 member 1 2.52317
FHL2 four and a half LIM domains 2 2.49528
C2CD2 C2 calcium-dependent domain containing 2 2.48697
NAGK N-acetylglucosamine kinase 2.38381
KCTD5 potassium channel tetramerization domain containing 5 2.35713
UBQLN2 ubiquilin 2 2.33215
RRAGC Ras-related GTP binding C 2.33
TNIP1 TNFAIP3 interacting protein 1 2.29467
H2BC21 H2B clustered histone 21 2.2917
DUSP5 dual specificity phosphatase 5 2.28812
CLTC clathrin, heavy chain (Hc) 2.26149
TMEM40 transmembrane protein 40 2.23996
CTSA cathepsin A 2.23469
RHOG ras homolog family member G 2.21986
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.19656
PGPEP1 pyroglutamyl-peptidase I 2.17395
ARL8B ADP-ribosylation factor-like 8B 2.1652
RASAL2 RAS protein activator like 2 2.13876
WASHC5 WASH complex subunit 5 2.13111
CDCP1 CUB domain containing protein 1 2.12382
PSEN2 presenilin 2 2.11109
TOM1 target of myb1 (chicken) 2.10342
NOP53 NOP53 ribosome biogenesis factor 2.10074
VEGFC vascular endothelial growth factor C 2.08503
CD63 CD63 molecule 2.083
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 2.07436
EFL1 elongation factor like GTPase 1 2.07377
GPR137B G protein-coupled receptor 137B 2.06273
CACFD1 calcium channel flower domain containing 1 2.05085
TRIP4 thyroid hormone receptor interactor 4 2.03811
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.03649
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.02876
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 2.02514
TMBIM1 transmembrane BAX inhibitor motif containing 1 2.01265
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.00179
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 2.00077

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -4.50919
CCNB1 cyclin B1 -4.18734
TOP2A topoisomerase (DNA) II alpha 170kDa -4.06429
MELK maternal embryonic leucine zipper kinase -3.99529
CDC20 cell division cycle 20 -3.94845
CDK1 cyclin-dependent kinase 1 -3.52106
PCNA proliferating cell nuclear antigen -3.37997
BAG3 BCL2-associated athanogene 3 -3.33626
CCNB2 cyclin B2 -3.31902
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -3.3176
BIRC5 baculoviral IAP repeat containing 5 -3.17943
HMMR hyaluronan-mediated motility receptor (RHAMM) -3.14067
KIF18B kinesin family member 18B -3.11442
KIF14 kinesin family member 14 -3.10517
PBK PDZ binding kinase -2.998
CENPA centromere protein A -2.90623
UBE2C ubiquitin-conjugating enzyme E2C -2.84278
KIF15 kinesin family member 15 -2.83217
MRPS27 mitochondrial ribosomal protein S27 -2.83191
RRM2 ribonucleotide reductase M2 -2.79641
KIF11 kinesin family member 11 -2.79534
CCNA2 cyclin A2 -2.71327
NUSAP1 nucleolar and spindle associated protein 1 -2.68536
CRYZ crystallin, zeta (quinone reductase) -2.67703
SPDL1 spindle apparatus coiled-coil protein 1 -2.65041
HMGB2 high mobility group box 2 -2.64489
RPA3 replication protein A3, 14kDa -2.64304
TCTA T-cell leukemia translocation altered -2.63612
ORC6 origin recognition complex, subunit 6 -2.63506
CDKN3 cyclin-dependent kinase inhibitor 3 -2.60424
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.57292
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.57074
H2AX H2A.X variant histone -2.56647
FAM216A family with sequence similarity 216, member A -2.51912
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.51749
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.50777
PIMREG PICALM interacting mitotic regulator -2.48931
CDC25B cell division cycle 25B -2.489
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.47416
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -2.46257
SESN1 sestrin 1 -2.46101
PTTG1 pituitary tumor-transforming 1 -2.44908
VRK1 vaccinia related kinase 1 -2.42608
EXO1 exonuclease 1 -2.41422
CKAP2 cytoskeleton associated protein 2 -2.40326
KIF4A kinesin family member 4A -2.397
TTK TTK protein kinase -2.39123
CDC7 cell division cycle 7 -2.35751
KIF20A kinesin family member 20A -2.3494
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.34539
NCAPG2 non-SMC condensin II complex, subunit G2 -2.331
ZWINT ZW10 interacting kinetochore protein -2.32565
GLDC glycine dehydrogenase (decarboxylating) -2.3162
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.31577
CKS2 CDC28 protein kinase regulatory subunit 2 -2.31251
FANCI Fanconi anemia, complementation group I -2.30621
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.28865
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.28121
MAK16 MAK16 homolog (S. cerevisiae) -2.23814
WDR43 WD repeat domain 43 -2.21821
PLK1 polo-like kinase 1 -2.18627
HMGN2 high mobility group nucleosomal binding domain 2 -2.1814
FBXO5 F-box protein 5 -2.17806
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -2.17537
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.1707
RFC3 replication factor C (activator 1) 3, 38kDa -2.16916
DCK deoxycytidine kinase -2.16643
ASF1B anti-silencing function 1B histone chaperone -2.15672
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -2.15272
TPX2 TPX2, microtubule-associated -2.14892
ESD esterase D -2.1473
BLMH bleomycin hydrolase -2.14359
RUVBL1 RuvB-like AAA ATPase 1 -2.14127
HJURP Holliday junction recognition protein -2.12992
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.1259
BZW2 basic leucine zipper and W2 domains 2 -2.12331
UBXN8 UBX domain protein 8 -2.12223
TRIP13 thyroid hormone receptor interactor 13 -2.1203
RACGAP1 Rac GTPase activating protein 1 -2.11908
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.11648
STMN1 stathmin 1 -2.11318
MRPS7 mitochondrial ribosomal protein S7 -2.09758
CYCS cytochrome c, somatic -2.09654
HADH hydroxyacyl-CoA dehydrogenase -2.09086
PRC1 protein regulator of cytokinesis 1 -2.0896
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.08744
CCNG1 cyclin G1 -2.06606
DBF4 DBF4 zinc finger -2.06273
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 -2.04512
DHFR dihydrofolate reductase -2.04328
PNPO pyridoxamine 5'-phosphate oxidase -2.03384
TRMT5 tRNA methyltransferase 5 -2.02753
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.02669
PTDSS1 phosphatidylserine synthase 1 -2.02638
RNFT1-DT RNFT1 divergent transcript -2.02445
DCTPP1 dCTP pyrophosphatase 1 -2.00798
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.00671