CRCGN015_MCF10A_48H:J18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-(1-naphthyl)ethylenediamine.2hcl 11.22 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN015_MCF10A_48H:J18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 4.75299
SSBP2 single-stranded DNA binding protein 2 3.86034
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.66885
SIRT3 sirtuin 3 2.5254
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2.32879
ERGIC2 ERGIC and golgi 2 2.2234
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.11203
TBC1D19 TBC1 domain family, member 19 2.08377
PSME3IP1 proteasome activator subunit 3 interacting protein 1 2.07739
LGMN legumain 2.04464
HLA-DOB major histocompatibility complex, class II, DO beta 2.01476
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) 2.00259

decreased expression

Symbol Name Standardized Value
PPIC peptidylprolyl isomerase C (cyclophilin C) -5.27398
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.93224
ENOPH1 enolase-phosphatase 1 -4.79101
ANXA3 annexin A3 -3.74865
MSMO1 methylsterol monooxygenase 1 -3.53365
VDAC1 voltage-dependent anion channel 1 -3.48839
S100A8 S100 calcium binding protein A8 -3.4761
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.40771
JMJD6 jumonji domain containing 6 -2.94394
NKRF NFKB repressing factor -2.57966
YARS1 tyrosyl-tRNA synthetase 1 -2.28996
MALT1 MALT1 paracaspase -2.22569
PLK2 polo-like kinase 2 -2.154
TTLL12 tubulin tyrosine ligase-like family member 12 -2.13898
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing -2.10221
RNF113A ring finger protein 113A -2.07386
PFKP phosphofructokinase, platelet -2.04896