CRCGN015_MCF10A_48H:K11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description wortmannin 3.33 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

216 genes differentially expressed following the CRCGN015_MCF10A_48H:K11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SMIM40 small integral membrane protein 40 3.49488
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.41897
MEF2C myocyte enhancer factor 2C 3.32228
PTK2B protein tyrosine kinase 2 beta 3.12976
HYOU1 hypoxia up-regulated 1 3.04413
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.99977
CDC45 cell division cycle 45 2.99813
KIFC1 kinesin family member C1 2.84949
RECQL4 RecQ protein-like 4 2.77593
INCENP inner centromere protein antigens 135/155kDa 2.75455
WIF1 WNT inhibitory factor 1 2.71713
COL4A1 collagen, type IV, alpha 1 2.71198
BICRA BRD4 interacting chromatin remodeling complex associated protein 2.68664
HMGA2 high mobility group AT-hook 2 2.64375
NCAPH non-SMC condensin I complex, subunit H 2.64229
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.62701
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.58204
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 2.58164
AURKB aurora kinase B 2.5159
MMRN1 multimerin 1 2.47871
CNTFR ciliary neurotrophic factor receptor 2.47819
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa 2.47168
DUSP6 dual specificity phosphatase 6 2.45417
PCSK7 proprotein convertase subtilisin/kexin type 7 2.42608
DCAF15 DDB1 and CUL4 associated factor 15 2.42367
NHERF4 NHERF family PDZ scaffold protein 4 2.41888
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 2.41529
LHX6 LIM homeobox 6 2.39568
ZNF696 zinc finger protein 696 2.39539
SLC30A3 solute carrier family 30 (zinc transporter), member 3 2.3903
RGCC regulator of cell cycle 2.36624
NRXN1 neurexin 1 2.35985
MMP10 matrix metallopeptidase 10 2.35566
FBXL6 F-box and leucine-rich repeat protein 6 2.34168
TRAIP TRAF interacting protein 2.34071
MXD3 MAX dimerization protein 3 2.33195
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7 2.31533
AQP8 aquaporin 8 2.30795
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.3022
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.29419
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 2.29224
TLN2 talin 2 2.28521
SRF serum response factor (c-fos serum response element-binding transcription factor) 2.28295
GPR161 G protein-coupled receptor 161 2.27726
ARRB2 arrestin, beta 2 2.26476
CA4 carbonic anhydrase IV 2.25565
CIDEB cell death-inducing DFFA-like effector b 2.25497
CEP170B centrosomal protein 170B 2.25359
KLF6 Kruppel-like factor 6 2.25156
ACVRL1 activin A receptor type II-like 1 2.25115
JOSD1 Josephin domain containing 1 2.25057
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.23291
CLCN6 chloride channel, voltage-sensitive 6 2.22493
IL12RB2 interleukin 12 receptor, beta 2 2.21596
TMED9 transmembrane emp24 protein transport domain containing 9 2.2091
BRS3 bombesin-like receptor 3 2.2051
KLF7 Kruppel-like factor 7 (ubiquitous) 2.20027
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 2.1949
HMGN1 high mobility group nucleosome binding domain 1 2.1847
STC1 stanniocalcin 1 2.1844
BORA bora, aurora kinase A activator 2.18163
DLK2 delta-like 2 homolog (Drosophila) 2.17068
OR10H1 olfactory receptor, family 10, subfamily H, member 1 2.1701
DRP2 dystrophin related protein 2 2.16849
NOTCH4 notch 4 2.16257
KCNK10 potassium channel, two pore domain subfamily K, member 10 2.15728
ADTRP androgen-dependent TFPI-regulating protein 2.14664
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene) 2.14557
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.13708
RNF186 ring finger protein 186 2.13657
OR2H1 olfactory receptor, family 2, subfamily H, member 1 2.13549
RAD51B RAD51 paralog B 2.13463
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 2.13367
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 2.132
CP ceruloplasmin (ferroxidase) 2.12586
CDHR5 cadherin-related family member 5 2.12538
FAM76A family with sequence similarity 76, member A 2.12321
MRAS muscle RAS oncogene homolog 2.11686
TCOF1 Treacher Collins-Franceschetti syndrome 1 2.11413
PHF13 PHD finger protein 13 2.11246
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.10369
PTPN9 protein tyrosine phosphatase, non-receptor type 9 2.09901
CNTNAP3B contactin associated protein-like 3B 2.09769
WRAP53 WD repeat containing, antisense to TP53 2.09632
WDR4 WD repeat domain 4 2.0963
NES nestin 2.09569
CRISP1 cysteine-rich secretory protein 1 2.09509
BAMBI BMP and activin membrane-bound inhibitor 2.09214
PLXNA2 plexin A2 2.08718
SLC6A16 solute carrier family 6, member 16 2.08537
TMSB15B thymosin beta 15B 2.08366
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.08271
MKS1 Meckel syndrome, type 1 2.08208
TRIM39-RPP21 TRIM39-RPP21 readthrough 2.07997
ARSL arylsulfatase L 2.07952
GCGR glucagon receptor 2.07835
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2.07346
A2M alpha-2-macroglobulin 2.07264
CNGA1 cyclic nucleotide gated channel alpha 1 2.06818
SHBG sex hormone-binding globulin 2.06782
KALRN kalirin, RhoGEF kinase 2.06751
RAD54L2 RAD54-like 2 (S. cerevisiae) 2.06741
PLEKHO1 pleckstrin homology domain containing, family O member 1 2.06586
FPR3 formyl peptide receptor 3 2.06142
AMOT angiomotin 2.06022
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 2.05364
E2F8 E2F transcription factor 8 2.04826
SIRT6 sirtuin 6 2.04385
PDE9A phosphodiesterase 9A 2.04297
FLT1 fms-related tyrosine kinase 1 2.04245
RAD51 RAD51 recombinase 2.04174
PLA2G2E phospholipase A2, group IIE 2.03916
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa 2.03878
PYHIN1 pyrin and HIN domain family, member 1 2.03708
SCN2A sodium channel, voltage gated, type II alpha subunit 2.0352
DIPK2B divergent protein kinase domain 2B 2.03149
ADAM7 ADAM metallopeptidase domain 7 2.02781
GCG glucagon 2.02354
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.02058
FHL2 four and a half LIM domains 2 2.02001
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.01923
CDT1 chromatin licensing and DNA replication factor 1 2.01866
AQP7 aquaporin 7 2.0158
C8B complement component 8, beta polypeptide 2.00937
GFI1B growth factor independent 1B transcription repressor 2.00436
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4 2.00304
ONECUT1 one cut homeobox 1 2.00276

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -8.57692
PLS1 plastin 1 -4.6639
ANXA3 annexin A3 -4.51612
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.08916
RGS2 regulator of G-protein signaling 2 -3.38127
BLMH bleomycin hydrolase -3.2113
ARFIP2 ADP-ribosylation factor interacting protein 2 -3.14362
ENOPH1 enolase-phosphatase 1 -3.11309
HSPA4L heat shock 70kDa protein 4-like -3.07509
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.9895
DMAC2L distal membrane arm assembly component 2 like -2.94683
STAT1 signal transducer and activator of transcription 1, 91kDa -2.85587
CPPED1 calcineurin-like phosphoesterase domain containing 1 -2.84562
CXCR2 chemokine (C-X-C motif) receptor 2 -2.80529
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.79607
SESN1 sestrin 1 -2.73997
ACP3 acid phosphatase 3 -2.70718
PCDHB16 protocadherin beta 16 -2.69458
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.51827
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.51728
TFB1M transcription factor B1, mitochondrial -2.51644
LAMP2 lysosomal-associated membrane protein 2 -2.50384
COG7 component of oligomeric golgi complex 7 -2.49577
GDE1 glycerophosphodiester phosphodiesterase 1 -2.46263
MAP2K4 mitogen-activated protein kinase kinase 4 -2.45442
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.44942
GSTA4 glutathione S-transferase alpha 4 -2.42547
HMG20B high mobility group 20B -2.42543
RFX5 regulatory factor X, 5 (influences HLA class II expression) -2.40994
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -2.40451
DENND10 DENN domain containing 10 -2.3997
ECD ecdysoneless homolog (Drosophila) -2.39115
COPS4 COP9 signalosome subunit 4 -2.3743
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain -2.37163
SLC25A46 solute carrier family 25, member 46 -2.34597
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 -2.33674
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.32768
MRPS33 mitochondrial ribosomal protein S33 -2.32649
DPY19L4 dpy-19-like 4 (C. elegans) -2.31454
AMACR alpha-methylacyl-CoA racemase -2.31429
PGM1 phosphoglucomutase 1 -2.30863
NEK7 NIMA-related kinase 7 -2.30771
RHOT1 ras homolog family member T1 -2.30338
SPRR2B small proline-rich protein 2B -2.30302
TMEM267 transmembrane protein 267 -2.29903
CDK7 cyclin-dependent kinase 7 -2.29781
BMPR1A bone morphogenetic protein receptor, type IA -2.29411
ADGRE5 adhesion G protein-coupled receptor E5 -2.29201
SORD sorbitol dehydrogenase -2.29102
PEX12 peroxisomal biogenesis factor 12 -2.29021
IPP intracisternal A particle-promoted polypeptide -2.28429
MBIP MAP3K12 binding inhibitory protein 1 -2.28192
PPARG peroxisome proliferator-activated receptor gamma -2.27591
MORC4 MORC family CW-type zinc finger 4 -2.26875
NBR1 neighbor of BRCA1 gene 1 -2.26484
ELOVL6 ELOVL fatty acid elongase 6 -2.25734
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.25114
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.24428
PROS1 protein S (alpha) -2.24341
TOM1L1 target of myb1 (chicken)-like 1 -2.2433
SNX6 sorting nexin 6 -2.24023
CRTAP cartilage associated protein -2.23909
ADNP activity-dependent neuroprotector homeobox -2.23797
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.22437
CCNG1 cyclin G1 -2.22135
OXSM 3-oxoacyl-ACP synthase, mitochondrial -2.21651
ACTR6 ARP6 actin-related protein 6 homolog (yeast) -2.1918
EMC6 ER membrane protein complex subunit 6 -2.18964
MRPL17 mitochondrial ribosomal protein L17 -2.16836
TRIM16 tripartite motif containing 16 -2.1606
ADGRE1 adhesion G protein-coupled receptor E1 -2.15824
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 -2.14894
AZIN2 antizyme inhibitor 2 -2.13734
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -2.1236
TERF2IP telomeric repeat binding factor 2, interacting protein -2.10419
SLC38A6 solute carrier family 38, member 6 -2.10136
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.10105
SCFD1 sec1 family domain containing 1 -2.08956
TMEM260 transmembrane protein 260 -2.08254
TSPAN8 tetraspanin 8 -2.07082
REPS2 RALBP1 associated Eps domain containing 2 -2.06806
TGM1 transglutaminase 1 -2.05676
LOC112694756 uncharaterized LOC112694756 -2.03992
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.02763
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -2.02523
ECH1 enoyl CoA hydratase 1, peroxisomal -2.01891
FASTKD3 FAST kinase domains 3 -2.01878
MSRB1 methionine sulfoxide reductase B1 -2.01338
ZNHIT3 zinc finger, HIT-type containing 3 -2.00532