CRCGN015_MCF10A_48H:K17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isobutyraldehyde 33.93 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN015_MCF10A_48H:K17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GRWD1 glutamate-rich WD repeat containing 1 5.8161
CETN3 centrin, EF-hand protein, 3 4.74285
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.66775
TRAPPC4 trafficking protein particle complex 4 3.43173
KCTD5 potassium channel tetramerization domain containing 5 3.2
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.02567
PUS3 pseudouridylate synthase 3 2.94125
DCPS decapping enzyme, scavenger 2.63265
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.5424
ZNF672 zinc finger protein 672 2.26795
ZNF189 zinc finger protein 189 2.26065
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.18725
GET1 guided entry of tail-anchored proteins factor 1 2.14925
CDC45 cell division cycle 45 2.0868
MKRN2 makorin ring finger protein 2 2.03385

decreased expression

Symbol Name Standardized Value
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.599
S100A8 S100 calcium binding protein A8 -5.5234
KRT7 keratin 7, type II -5.3077
KRT14 keratin 14, type I -5.028
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.25315
CSRP2 cysteine and glycine-rich protein 2 -2.99003
REEP5 receptor accessory protein 5 -2.96175
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.83247
PLTP phospholipid transfer protein -2.6289
GRB7 growth factor receptor-bound protein 7 -2.61355
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -2.48805
PARP6 poly (ADP-ribose) polymerase family, member 6 -2.3144
GSDMB gasdermin B -2.30955
TH tyrosine hydroxylase -2.29315
CAB39L calcium binding protein 39-like -2.28395
EPHB6 EPH receptor B6 -2.22665
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -2.22535
DGKI diacylglycerol kinase, iota -2.2208
PCSK2 proprotein convertase subtilisin/kexin type 2 -2.15685
ZNF507 zinc finger protein 507 -2.1362
ITGB1BP1 integrin beta 1 binding protein 1 -2.10222
PDE10A phosphodiesterase 10A -2.08978
ABHD8 abhydrolase domain containing 8 -2.0737
IFNA7 interferon, alpha 7 -2.066
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 -2.06375
MELK maternal embryonic leucine zipper kinase -2.05435
CLDN16 claudin 16 -2.0509
POLM polymerase (DNA directed), mu -2.0487
ANXA10 annexin A10 -2.03965
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 -2.0362
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 -2.0257
RYR2 ryanodine receptor 2 (cardiac) -2.02283
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -2.00475