CRCGN015_MCF10A_48H:K22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tris(2-chloroethyl) phosphate 100.3 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

133 genes differentially expressed following the CRCGN015_MCF10A_48H:K22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 4.98665
CHMP6 charged multivesicular body protein 6 4.85858
ADAM10 ADAM metallopeptidase domain 10 4.7607
PFKL phosphofructokinase, liver 3.99076
GATA3 GATA binding protein 3 3.95954
MAST2 microtubule associated serine/threonine kinase 2 3.78657
CXCL2 chemokine (C-X-C motif) ligand 2 3.70188
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 3.61706
GATD3 glutamine amidotransferase class 1 domain containing 3 3.61529
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 3.14694
HYOU1 hypoxia up-regulated 1 2.99656
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.92048
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.89353
TP53TG5 TP53 target 5 2.616
EHMT1 euchromatic histone-lysine N-methyltransferase 1 2.57472
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 2.56311
HDGFL3 HDGF like 3 2.52364
RANGAP1 Ran GTPase activating protein 1 2.50037
ELP3 elongator acetyltransferase complex subunit 3 2.4954
RHOBTB1 Rho-related BTB domain containing 1 2.48544
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.45663
WDR4 WD repeat domain 4 2.4431
TRAPPC10 trafficking protein particle complex 10 2.4409
MPST mercaptopyruvate sulfurtransferase 2.43702
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase 2.43624
MMRN1 multimerin 1 2.41477
DGCR2 DiGeorge syndrome critical region gene 2 2.3895
MYBBP1A MYB binding protein (P160) 1a 2.36448
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 2.34112
CCDC134 coiled-coil domain containing 134 2.33239
OBP2B odorant binding protein 2B 2.32793
NAT10 N-acetyltransferase 10 (GCN5-related) 2.31577
ARFRP1 ADP-ribosylation factor related protein 1 2.31326
FBXL6 F-box and leucine-rich repeat protein 6 2.31316
CCNJ cyclin J 2.30628
BNC1 basonuclin 1 2.29482
DNAH17 dynein, axonemal, heavy chain 17 2.27498
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase 2.27186
PITPNB phosphatidylinositol transfer protein, beta 2.26486
SLC38A10 solute carrier family 38, member 10 2.26383
MICB MHC class I polypeptide-related sequence B 2.26283
SGSH N-sulfoglucosamine sulfohydrolase 2.25717
DPYSL4 dihydropyrimidinase-like 4 2.24863
SMG9 SMG9 nonsense mediated mRNA decay factor 2.23748
CHEK1 checkpoint kinase 1 2.23615
ODF2 outer dense fiber of sperm tails 2 2.21993
PLSCR3 phospholipid scramblase 3 2.21295
ADTRP androgen-dependent TFPI-regulating protein 2.21066
PPP6R1 protein phosphatase 6, regulatory subunit 1 2.20829
GLDC glycine dehydrogenase (decarboxylating) 2.20193
RTL10 retrotransposon Gag like 10 2.19782
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.1946
ELAC1 elaC ribonuclease Z 1 2.17587
PYY peptide YY 2.16346
EDC3 enhancer of mRNA decapping 3 2.14584
NME6 NME/NM23 nucleoside diphosphate kinase 6 2.12706
LSR lipolysis stimulated lipoprotein receptor 2.12086
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 2.1207
CDC6 cell division cycle 6 2.11927
AKAP4 A kinase (PRKA) anchor protein 4 2.11355
FGFR3 fibroblast growth factor receptor 3 2.10747
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 2.10578
BRDT bromodomain, testis-specific 2.10539
SPC25 SPC25, NDC80 kinetochore complex component 2.10366
TRPC7 transient receptor potential cation channel, subfamily C, member 7 2.09363
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 2.08918
E2F8 E2F transcription factor 8 2.08825
ZMYM1 zinc finger, MYM-type 1 2.07782
TMEM259 transmembrane protein 259 2.07322
GSDME gasdermin E 2.0635
PTPN14 protein tyrosine phosphatase, non-receptor type 14 2.0616
PECR peroxisomal trans-2-enoyl-CoA reductase 2.05722
RAD54L RAD54-like (S. cerevisiae) 2.055
EXD3 exonuclease 3'-5' domain containing 3 2.05404
BARX2 BARX homeobox 2 2.04993
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 2.04738
HPSE heparanase 2.04708
PMCH pro-melanin-concentrating hormone 2.04685
FXYD2 FXYD domain containing ion transport regulator 2 2.04265
ZNF135 zinc finger protein 135 2.04193
PLXNB1 plexin B1 2.03571
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) 2.03457
LY6E lymphocyte antigen 6 complex, locus E 2.03339
FAAP100 FA core complex associated protein 100 2.02832
YOD1 YOD1 deubiquitinase 2.02787
VAV2 vav 2 guanine nucleotide exchange factor 2.01927
PDIA2 protein disulfide isomerase family A, member 2 2.00831
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.00761
APLP1 amyloid beta (A4) precursor-like protein 1 2.00396
RBBP8 retinoblastoma binding protein 8 2.00162

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.43234
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.91302
CDC20 cell division cycle 20 -4.8173
CCNB1 cyclin B1 -4.64712
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.41922
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -4.25212
AXIN1 axin 1 -3.19055
CTSL cathepsin L -2.97409
GTF3A general transcription factor IIIA -2.94074
KRT14 keratin 14, type I -2.85338
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.76708
IFT88 intraflagellar transport 88 -2.62556
MLPH melanophilin -2.57744
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -2.4477
S100P S100 calcium binding protein P -2.43726
PLEK2 pleckstrin 2 -2.4216
PZP pregnancy-zone protein -2.39522
CDK8 cyclin-dependent kinase 8 -2.38581
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) -2.37683
SAP18 Sin3A-associated protein, 18kDa -2.37578
MAGED2 melanoma antigen family D2 -2.32533
ALOX5AP arachidonate 5-lipoxygenase-activating protein -2.28677
RPS5 ribosomal protein S5 -2.27491
SDF2 stromal cell-derived factor 2 -2.2351
STK26 serine/threonine protein kinase 26 -2.20204
AK6 adenylate kinase 6 -2.17646
DENND10 DENN domain containing 10 -2.1558
RAD17 RAD17 homolog (S. pombe) -2.13473
SYNGR3 synaptogyrin 3 -2.13287
MISP mitotic spindle positioning -2.12612
YIPF1 Yip1 domain family, member 1 -2.11973
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -2.11437
SNX3 sorting nexin 3 -2.1085
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -2.09913
ITGB1BP1 integrin beta 1 binding protein 1 -2.07931
EIF1B eukaryotic translation initiation factor 1B -2.06491
INTS12 integrator complex subunit 12 -2.05834
AP1M2 adaptor-related protein complex 1, mu 2 subunit -2.05305
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like -2.05173
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -2.02118
ZBTB35 zinc finger and BTB domain containing 35 -2.00721
COBL cordon-bleu WH2 repeat protein -2.00185
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -2.00079