CRCGN015_MCF10A_48H:L03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description aflatoxin-b1 10.7 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

119 genes differentially expressed following the CRCGN015_MCF10A_48H:L03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 5.55889
LAGE3 L antigen family, member 3 3.80091
ADAM10 ADAM metallopeptidase domain 10 3.52279
TXNL4B thioredoxin-like 4B 3.22402
RGS2 regulator of G-protein signaling 2 2.8841
SESN1 sestrin 1 2.81205
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 2.71866
AEN apoptosis enhancing nuclease 2.51458
CCDC51 coiled-coil domain containing 51 2.48183
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 2.45925
FDXR ferredoxin reductase 2.43123
AMACR alpha-methylacyl-CoA racemase 2.42765
RND1 Rho family GTPase 1 2.38669
ANO10 anoctamin 10 2.33287
NCOA1 nuclear receptor coactivator 1 2.32489
CALCOCO1 calcium binding and coiled-coil domain 1 2.30417
FHL2 four and a half LIM domains 2 2.25622
AHNAK2 AHNAK nucleoprotein 2 2.25219
GDI1 GDP dissociation inhibitor 1 2.24457
DUSP14 dual specificity phosphatase 14 2.22754
TEX2 testis expressed 2 2.10329
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 2.08154
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.05947
LHB luteinizing hormone beta polypeptide 2.04612
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.03066
ZMAT3 zinc finger, matrin-type 3 2.01303

decreased expression

Symbol Name Standardized Value
MELK maternal embryonic leucine zipper kinase -4.87178
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.70242
SNX7 sorting nexin 7 -4.3691
HSPA1A heat shock 70kDa protein 1A -4.30448
CDC20 cell division cycle 20 -3.65475
TOP2A topoisomerase (DNA) II alpha 170kDa -3.64233
CCNB2 cyclin B2 -3.51888
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -3.47387
KIF11 kinesin family member 11 -3.47036
PCNA proliferating cell nuclear antigen -3.34186
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.20765
BIRC5 baculoviral IAP repeat containing 5 -3.20444
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -3.10423
KIF14 kinesin family member 14 -3.10194
SPC25 SPC25, NDC80 kinetochore complex component -3.05102
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -3.04023
DCK deoxycytidine kinase -3.03538
TTK TTK protein kinase -3.03498
CCNA2 cyclin A2 -2.87104
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.86353
RFC3 replication factor C (activator 1) 3, 38kDa -2.84944
NCAPG2 non-SMC condensin II complex, subunit G2 -2.83574
PLK1 polo-like kinase 1 -2.83425
ASF1B anti-silencing function 1B histone chaperone -2.79897
RFC4 replication factor C (activator 1) 4, 37kDa -2.78254
PARP2 poly (ADP-ribose) polymerase 2 -2.76092
NUSAP1 nucleolar and spindle associated protein 1 -2.74104
HJURP Holliday junction recognition protein -2.73614
FANCI Fanconi anemia, complementation group I -2.72704
DEK DEK proto-oncogene -2.68299
PSRC1 proline/serine-rich coiled-coil 1 -2.65929
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.6441
CDT1 chromatin licensing and DNA replication factor 1 -2.61005
CD24 CD24 molecule -2.6065
MCM6 minichromosome maintenance complex component 6 -2.56822
CENPU centromere protein U -2.56651
DEPDC1 DEP domain containing 1 -2.55853
STMN1 stathmin 1 -2.55713
KIF4A kinesin family member 4A -2.55103
UBE2C ubiquitin-conjugating enzyme E2C -2.54961
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.54834
EXOSC8 exosome component 8 -2.54537
NCAPH non-SMC condensin I complex, subunit H -2.53548
FOXM1 forkhead box M1 -2.53003
FBXO5 F-box protein 5 -2.5135
HMGB2 high mobility group box 2 -2.50877
PRC1 protein regulator of cytokinesis 1 -2.48208
USP39 ubiquitin specific peptidase 39 -2.47919
EXO1 exonuclease 1 -2.46158
NEK2 NIMA-related kinase 2 -2.44488
CDC45 cell division cycle 45 -2.43905
CDK1 cyclin-dependent kinase 1 -2.42624
TK1 thymidine kinase 1, soluble -2.39499
SPAG5 sperm associated antigen 5 -2.3689
CDC6 cell division cycle 6 -2.34852
FEN1 flap structure-specific endonuclease 1 -2.32746
CHEK1 checkpoint kinase 1 -2.31691
PIMREG PICALM interacting mitotic regulator -2.31385
PARPBP PARP1 binding protein -2.31299
DHFR dihydrofolate reductase -2.30946
ECT2 epithelial cell transforming 2 -2.30431
MCM7 minichromosome maintenance complex component 7 -2.30264
NSD2 nuclear receptor binding SET domain protein 2 -2.26796
KIF15 kinesin family member 15 -2.26477
PLK4 polo-like kinase 4 -2.26088
SNRPA small nuclear ribonucleoprotein polypeptide A -2.25675
USP1 ubiquitin specific peptidase 1 -2.2393
ZWINT ZW10 interacting kinetochore protein -2.22845
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.21997
MCM5 minichromosome maintenance complex component 5 -2.2138
OIP5 Opa interacting protein 5 -2.211
TMPO thymopoietin -2.19001
H2AZ2 H2A.Z variant histone 2 -2.17026
MCM10 minichromosome maintenance complex component 10 -2.15881
NDC80 NDC80 kinetochore complex component -2.15526
CDKN3 cyclin-dependent kinase inhibitor 3 -2.13201
PTTG1 pituitary tumor-transforming 1 -2.11891
LMNB1 lamin B1 -2.11047
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.1085
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.09244
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.09096
SMN2 survival of motor neuron 2, centromeric -2.07844
KIF23 kinesin family member 23 -2.06708
CDCA8 cell division cycle associated 8 -2.06544
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.06044
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.05843
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.05229
RAD51AP1 RAD51 associated protein 1 -2.04428
SMC3 structural maintenance of chromosomes 3 -2.04291
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.03907
DBF4 DBF4 zinc finger -2.03778
STIL SCL/TAL1 interrupting locus -2.00607
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.00334