CRCGN015_MCF10A_48H:L05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-phenyl-p-phenylenediamine.hcl 32.93 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

96 genes differentially expressed following the CRCGN015_MCF10A_48H:L05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
METRN meteorin, glial cell differentiation regulator 5.05907
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.00929
SNX11 sorting nexin 11 4.17522
ANO10 anoctamin 10 3.98848
IL4R interleukin 4 receptor 3.6689
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 3.4057
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.98689
MYH9 myosin, heavy chain 9, non-muscle 2.91314
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 2.64175
FRAT2 frequently rearranged in advanced T-cell lymphomas 2 2.55444
CBX1 chromobox homolog 1 2.46444
MYO6 myosin VI 2.42502
ZDHHC18 zinc finger, DHHC-type containing 18 2.37249
FAM50A family with sequence similarity 50, member A 2.34697
CXCR2 chemokine (C-X-C motif) receptor 2 2.32987
HOXA7 homeobox A7 2.32005
CHEK2 checkpoint kinase 2 2.3014
MSRA methionine sulfoxide reductase A 2.29549
SLC25A44 solute carrier family 25, member 44 2.28146
PKN1 protein kinase N1 2.27114
IER3 immediate early response 3 2.25615
TMEM59 transmembrane protein 59 2.2267
CHIC2 cysteine-rich hydrophobic domain 2 2.22253
KLF7 Kruppel-like factor 7 (ubiquitous) 2.2151
HMOX1 heme oxygenase 1 2.21054
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.20167
LRRC59 leucine rich repeat containing 59 2.16588
REPS1 RALBP1 associated Eps domain containing 1 2.13931
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 2.13896
MID1IP1 MID1 interacting protein 1 2.13757
CLTC clathrin, heavy chain (Hc) 2.13215
NSF N-ethylmaleimide-sensitive factor 2.11081
GPR137B G protein-coupled receptor 137B 2.10359
CST2 cystatin SA 2.08562
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.07922
RSF1 remodeling and spacing factor 1 2.06004
EPPK1 epiplakin 1 2.04892
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 2.04386
EXOC2 exocyst complex component 2 2.03643
BCL2L13 BCL2-like 13 (apoptosis facilitator) 2.02054
ABHD5 abhydrolase domain containing 5 2.01997
CXCR1 chemokine (C-X-C motif) receptor 1 2.00422

decreased expression

Symbol Name Standardized Value
COG7 component of oligomeric golgi complex 7 -5.07591
UFM1 ubiquitin-fold modifier 1 -4.71677
SLC25A46 solute carrier family 25, member 46 -4.38757
CCDC86 coiled-coil domain containing 86 -4.1296
S100A8 S100 calcium binding protein A8 -3.29933
EXOSC8 exosome component 8 -3.25848
MT2A metallothionein 2A -3.1443
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -3.11143
FOXJ3 forkhead box J3 -3.06681
RNFT1-DT RNFT1 divergent transcript -3.0507
MRPS31 mitochondrial ribosomal protein S31 -2.69612
LCMT1 leucine carboxyl methyltransferase 1 -2.69085
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -2.65568
SMN2 survival of motor neuron 2, centromeric -2.58063
KANSL2 KAT8 regulatory NSL complex subunit 2 -2.56602
MTRF1 mitochondrial translational release factor 1 -2.44121
LRRC40 leucine rich repeat containing 40 -2.43398
CDK1 cyclin-dependent kinase 1 -2.40323
PARP2 poly (ADP-ribose) polymerase 2 -2.40051
RFC3 replication factor C (activator 1) 3, 38kDa -2.3883
DCK deoxycytidine kinase -2.34234
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -2.3257
PALB2 partner and localizer of BRCA2 -2.3253
PAK1IP1 PAK1 interacting protein 1 -2.29117
IPO4 importin 4 -2.27001
PTOV1 prostate tumor overexpressed 1 -2.26799
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -2.26523
PRMT1 protein arginine methyltransferase 1 -2.23189
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) -2.22289
COL6A3 collagen, type VI, alpha 3 -2.21675
MTMR6 myotubularin related protein 6 -2.20808
NOP2 NOP2 nucleolar protein -2.17279
REXO5 RNA exonuclease 5 -2.16982
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.1232
UBA5 ubiquitin-like modifier activating enzyme 5 -2.11592
RFC4 replication factor C (activator 1) 4, 37kDa -2.11345
SSRP1 structure specific recognition protein 1 -2.09729
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -2.08935
CA9 carbonic anhydrase IX -2.0849
IFT52 intraflagellar transport 52 -2.08357
NR1H3 nuclear receptor subfamily 1, group H, member 3 -2.07813
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 -2.07668
TGDS TDP-glucose 4,6-dehydratase -2.0749
SH3TC1 SH3 domain and tetratricopeptide repeats 1 -2.0712
TUBGCP3 tubulin, gamma complex associated protein 3 -2.04696
PHB2 prohibitin 2 -2.04313
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -2.03951
PRMT3 protein arginine methyltransferase 3 -2.0355
NCAPD3 non-SMC condensin II complex, subunit D3 -2.02584
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 -2.02317
AHR aryl hydrocarbon receptor -2.01909
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) -2.01489
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 -2.00623
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 -2.00209