CRCGN015_MCF10A_48H:L14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description etodolac 33.27 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN015_MCF10A_48H:L14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STAP2 signal transducing adaptor family member 2 5.78114
PRKCQ protein kinase C, theta 4.79494
MAMLD1 mastermind-like domain containing 1 4.55899
AMDHD2 amidohydrolase domain containing 2 4.55859
SSBP2 single-stranded DNA binding protein 2 3.9598
UBQLN2 ubiquilin 2 3.68891
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.71081
GRAMD1B GRAM domain containing 1B 2.42616
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.4206
GPR20 G protein-coupled receptor 20 2.34221
LTC4S leukotriene C4 synthase 2.3217
TOP6BL TOP6B like initiator of meiotic double strand breaks 2.26745
KCNK10 potassium channel, two pore domain subfamily K, member 10 2.25656
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 2.23576
CLSTN2 calsyntenin 2 2.18432
TMEM184C transmembrane protein 184C 2.12229
TOX thymocyte selection-associated high mobility group box 2.1134
KRABD4 KRAB domain containing 4 2.113
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 2.09461
PTGDS prostaglandin D2 synthase 21kDa (brain) 2.0526
HAVCR1 hepatitis A virus cellular receptor 1 2.008

decreased expression

Symbol Name Standardized Value
RPA3 replication protein A3, 14kDa -4.91527
VIM vimentin -4.48008
PLS1 plastin 1 -3.43153
ARPP19 cAMP-regulated phosphoprotein, 19kDa -3.03267
ZDHHC4 zinc finger, DHHC-type containing 4 -2.68722
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -2.60421
MRM2 mitochondrial rRNA methyltransferase 2 -2.56539
DNAAF5 dynein, axonemal, assembly factor 5 -2.47672
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.33041
CSRP2 cysteine and glycine-rich protein 2 -2.31563
FSCN1 fascin actin-bundling protein 1 -2.303
PIEZO2 piezo-type mechanosensitive ion channel component 2 -2.21459
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 -2.20352
KLHDC2 kelch domain containing 2 -2.19528
PLK2 polo-like kinase 2 -2.11446
LPCAT1 lysophosphatidylcholine acyltransferase 1 -2.0962
MIOS missing oocyte, meiosis regulator, homolog (Drosophila) -2.05355
F3 coagulation factor III (thromboplastin, tissue factor) -2.03131
ACTMAP actin maturation protease -2.00865