CRCGN015_MCF10A_48H:L21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dichlorobenzidine 10.75 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

22 genes differentially expressed following the CRCGN015_MCF10A_48H:L21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 2.6916
TRIT1 tRNA isopentenyltransferase 1 2.17023
HMGN1 high mobility group nucleosome binding domain 1 2.16833
TOMM34 translocase of outer mitochondrial membrane 34 2.16625
PRSS58 protease, serine, 58 2.01649

decreased expression

Symbol Name Standardized Value
S100A8 S100 calcium binding protein A8 -5.96475
MRPS16 mitochondrial ribosomal protein S16 -5.63321
BAG3 BCL2-associated athanogene 3 -4.88836
MICU1 mitochondrial calcium uptake 1 -2.98405
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme -2.53344
FASTKD5 FAST kinase domains 5 -2.48109
SIRT1 sirtuin 1 -2.44906
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) -2.36384
TM9SF3 transmembrane 9 superfamily member 3 -2.32665
ASCC1 activating signal cointegrator 1 complex subunit 1 -2.22692
REEP5 receptor accessory protein 5 -2.13579
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 -2.09428
NR1H3 nuclear receptor subfamily 1, group H, member 3 -2.09236
AGAP4 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 -2.05048
CCNL2 cyclin L2 -2.01794
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 -2.00915
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) -2.00839