CRCGN015_MCF10A_48H:L22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description carbon-tetrachloride 98.3 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

72 genes differentially expressed following the CRCGN015_MCF10A_48H:L22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCDC92 coiled-coil domain containing 92 5.1151
STK10 serine/threonine kinase 10 4.46349
PIEZO1 piezo-type mechanosensitive ion channel component 1 3.0897
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 2.7685
RNF144A ring finger protein 144A 2.74746
TRAP1 TNF receptor-associated protein 1 2.68035
CELF2 CUGBP, Elav-like family member 2 2.67476
ACAA1 acetyl-CoA acyltransferase 1 2.62764
KLHL3 kelch-like family member 3 2.49737
WDR7 WD repeat domain 7 2.43781
NECAP1 NECAP endocytosis associated 1 2.42682
RPAP1 RNA polymerase II associated protein 1 2.41923
ESYT1 extended synaptotagmin-like protein 1 2.4103
SKIC2 SKI2 subunit of superkiller complex 2.36777
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.36215
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 2.35548
FHIT fragile histidine triad 2.33007
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 2.2908
MADD MAP-kinase activating death domain 2.2776
GTPBP6 GTP binding protein 6 (putative) 2.25862
ZNF280A zinc finger protein 280A 2.25485
PCM1 pericentriolar material 1 2.25328
EIPR1 EARP complex and GARP complex interacting protein 1 2.22429
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.22184
NIPSNAP2 nipsnap homolog 2 2.20582
BNC2 basonuclin 2 2.17634
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.17304
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.16851
EML3 echinoderm microtubule associated protein like 3 2.1665
MEN1 multiple endocrine neoplasia I 2.15036
AARS1 alanyl-tRNA synthetase 1 2.14125
CMTR1 cap methyltransferase 1 2.12552
USP6NL USP6 N-terminal like 2.12326
CLEC16A C-type lectin domain family 16, member A 2.08609
LIMD1 LIM domains containing 1 2.07459
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.07191
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 2.06754
DCN decorin 2.06386
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 2.0538
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 2.03419
KDM3B lysine (K)-specific demethylase 3B 2.02813
CCDC86 coiled-coil domain containing 86 2.02727
CLASP2 cytoplasmic linker associated protein 2 2.01725
PTGDR prostaglandin D2 receptor (DP) 2.01407
ZNF280B zinc finger protein 280B 2.00425
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.00052

decreased expression

Symbol Name Standardized Value
GRN granulin -3.93875
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.92207
MSMO1 methylsterol monooxygenase 1 -3.90265
KRT14 keratin 14, type I -3.89136
KIF14 kinesin family member 14 -3.76305
CD24 CD24 molecule -3.75767
TNIP1 TNFAIP3 interacting protein 1 -3.06341
IFI30 interferon, gamma-inducible protein 30 -2.85518
TUBB4B tubulin, beta 4B class IVb -2.70948
PDLIM1 PDZ and LIM domain 1 -2.46116
TGFBI transforming growth factor, beta-induced, 68kDa -2.45189
PGAM4 phosphoglycerate mutase family member 4 -2.45011
STXBP2 syntaxin binding protein 2 -2.44025
TM9SF3 transmembrane 9 superfamily member 3 -2.32555
TMSB4X thymosin beta 4, X-linked -2.30121
S100A2 S100 calcium binding protein A2 -2.27652
BCAR3 breast cancer anti-estrogen resistance 3 -2.26534
TTPAL tocopherol (alpha) transfer protein-like -2.19931
SPIB Spi-B transcription factor (Spi-1/PU.1 related) -2.10924
FBXO7 F-box protein 7 -2.10681
ITGAV integrin, alpha V -2.07403
MRPL30 mitochondrial ribosomal protein L30 -2.07332
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -2.06957
CBX1 chromobox homolog 1 -2.0479
BDNF brain-derived neurotrophic factor -2.0235
AGMAT agmatine ureohydrolase (agmatinase) -2.00179