CRCGN015_MCF10A_48H:M03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nitromethane 11.09 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

30 genes differentially expressed following the CRCGN015_MCF10A_48H:M03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SMIM40 small integral membrane protein 40 4.70568
MCOLN1 mucolipin 1 3.60021
WIF1 WNT inhibitory factor 1 3.4926
MYLK myosin light chain kinase 3.28103
PRR15L proline rich 15-like 3.11993
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.66901
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 2.56458
TXNL1 thioredoxin-like 1 2.33652
NPY1R neuropeptide Y receptor Y1 2.33648
SPARCL1 SPARC-like 1 (hevin) 2.3063
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.2596
MGP matrix Gla protein 2.22365
TGIF1 TGFB-induced factor homeobox 1 2.161
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 2.12345
ZNF516 zinc finger protein 516 2.0782
IDH3B isocitrate dehydrogenase 3 (NAD+) beta 2.06592
RBP1 retinol binding protein 1, cellular 2.05867
MYG1 MYG1 exonuclease 2.04723
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 2.01629

decreased expression

Symbol Name Standardized Value
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -5.09892
DIPK1A divergent protein kinase domain 1A -4.96482
SLC25A46 solute carrier family 25, member 46 -4.85979
PLS1 plastin 1 -3.52981
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.94775
ATG4A autophagy related 4A, cysteine peptidase -2.57785
CTSL cathepsin L -2.41625
RALGDS ral guanine nucleotide dissociation stimulator -2.38779
SH3TC1 SH3 domain and tetratricopeptide repeats 1 -2.17192
HPRT1 hypoxanthine phosphoribosyltransferase 1 -2.05623
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 -2.01998