CRCGN015_MCF10A_48H:M08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description norethynodrel 33.43 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

243 genes differentially expressed following the CRCGN015_MCF10A_48H:M08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WIF1 WNT inhibitory factor 1 5.33064
GFPT1 glutamine--fructose-6-phosphate transaminase 1 4.60954
FHL2 four and a half LIM domains 2 4.44994
TXNRD1 thioredoxin reductase 1 4.08375
NUCB2 nucleobindin 2 4.06484
SQSTM1 sequestosome 1 3.97594
IL4R interleukin 4 receptor 3.78436
KIFBP kinesin family binding protein 3.71537
DUSP4 dual specificity phosphatase 4 3.24623
WIPI1 WD repeat domain, phosphoinositide interacting 1 3.23842
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 3.19033
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.18163
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.16308
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.15204
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 3.07022
TERF2IP telomeric repeat binding factor 2, interacting protein 2.98413
DUSP6 dual specificity phosphatase 6 2.68584
CLTC clathrin, heavy chain (Hc) 2.66298
SPAG4 sperm associated antigen 4 2.66259
ACTN4 actinin, alpha 4 2.58034
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.56944
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.55288
NAGK N-acetylglucosamine kinase 2.48203
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.46604
IQGAP1 IQ motif containing GTPase activating protein 1 2.45964
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.45819
LRRC41 leucine rich repeat containing 41 2.42217
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.40583
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 2.39367
P4HB prolyl 4-hydroxylase, beta polypeptide 2.34274
TMEM214 transmembrane protein 214 2.3415
ULBP2 UL16 binding protein 2 2.31726
FAM114A1 family with sequence similarity 114, member A1 2.2687
CREB3L2 cAMP responsive element binding protein 3-like 2 2.26831
GLRX glutaredoxin (thioltransferase) 2.25633
TCHH trichohyalin 2.25207
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 2.24434
FEM1C fem-1 homolog c (C. elegans) 2.23833
BCAR3 breast cancer anti-estrogen resistance 3 2.23638
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 2.22824
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.22588
GPX2 glutathione peroxidase 2 2.20297
ACBD3 acyl-CoA binding domain containing 3 2.19686
MAP1B microtubule-associated protein 1B 2.1956
COPG1 coatomer protein complex, subunit gamma 1 2.19546
IER3 immediate early response 3 2.19283
NDRG4 NDRG family member 4 2.19196
HMGA2 high mobility group AT-hook 2 2.18626
ITPRID2 ITPR interacting domain containing 2 2.1721
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.16836
COLGALT2 collagen beta(1-O)galactosyltransferase 2 2.13294
NRCAM neuronal cell adhesion molecule 2.12267
KIF3C kinesin family member 3C 2.11363
MALT1 MALT1 paracaspase 2.09354
GPR107 G protein-coupled receptor 107 2.07314
STXBP1 syntaxin binding protein 1 2.07156
MSX2 msh homeobox 2 2.06973
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 2.06412
OSBPL10 oxysterol binding protein-like 10 2.05534
TCP11L1 t-complex 11, testis-specific-like 1 2.05123
CBR1 carbonyl reductase 1 2.04663
FNDC3B fibronectin type III domain containing 3B 2.03779
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 2.0373
LAMB3 laminin, beta 3 2.02743
SYTL3 synaptotagmin-like 3 2.02166
SIL1 SIL1 nucleotide exchange factor 2.02143
NDEL1 nudE neurodevelopment protein 1-like 1 2.01771
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.01419
CBR3 carbonyl reductase 3 2.01392
SUCO SUN domain containing ossification factor 2.00493
BSDC1 BSD domain containing 1 2.00182

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -5.02041
CYCS cytochrome c, somatic -4.68287
CCNB1 cyclin B1 -4.65374
NCK1 NCK adaptor protein 1 -4.36181
CCNB2 cyclin B2 -4.11738
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.99875
PLK1 polo-like kinase 1 -3.80758
TTK TTK protein kinase -3.59594
RPIA ribose 5-phosphate isomerase A -3.52119
TSC22D3 TSC22 domain family, member 3 -3.34945
HMMR hyaluronan-mediated motility receptor (RHAMM) -3.29964
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -3.27346
NEK2 NIMA-related kinase 2 -3.2642
LDHB lactate dehydrogenase B -3.14822
BIRC5 baculoviral IAP repeat containing 5 -3.10293
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -3.08374
CKS2 CDC28 protein kinase regulatory subunit 2 -3.07533
TOP2A topoisomerase (DNA) II alpha 170kDa -3.06898
TEX10 testis expressed 10 -3.05
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -3.02032
DCK deoxycytidine kinase -3.01891
AHCY adenosylhomocysteinase -3.01727
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -2.98144
PNRC2 proline-rich nuclear receptor coactivator 2 -2.95991
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A -2.94959
CDC25C cell division cycle 25C -2.90112
KIF4A kinesin family member 4A -2.8858
CENPA centromere protein A -2.86731
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.8558
NUP85 nucleoporin 85kDa -2.84902
CCNA2 cyclin A2 -2.84484
UBE2C ubiquitin-conjugating enzyme E2C -2.82773
MRPS22 mitochondrial ribosomal protein S22 -2.79216
PSRC1 proline/serine-rich coiled-coil 1 -2.78681
PCNA proliferating cell nuclear antigen -2.78642
TCEAL4 transcription elongation factor A (SII)-like 4 -2.75309
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.74838
MRPS7 mitochondrial ribosomal protein S7 -2.74751
CDK1 cyclin-dependent kinase 1 -2.72526
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.7199
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.71766
CDC25B cell division cycle 25B -2.69361
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -2.69359
LBR lamin B receptor -2.68375
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.68277
COG2 component of oligomeric golgi complex 2 -2.67364
MCRS1 microspherule protein 1 -2.6363
KIF20A kinesin family member 20A -2.61599
PNRC1 proline-rich nuclear receptor coactivator 1 -2.60985
TROAP trophinin associated protein -2.60083
DDIT4 DNA-damage-inducible transcript 4 -2.59816
MRPS27 mitochondrial ribosomal protein S27 -2.59745
H2AX H2A.X variant histone -2.59393
NDC80 NDC80 kinetochore complex component -2.58056
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.5798
PRR15L proline rich 15-like -2.57553
PBK PDZ binding kinase -2.56169
APIP APAF1 interacting protein -2.55088
MLF1 myeloid leukemia factor 1 -2.52268
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -2.51069
HMGB2 high mobility group box 2 -2.49918
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.47842
DEK DEK proto-oncogene -2.47787
PIMREG PICALM interacting mitotic regulator -2.47154
IGBP1 immunoglobulin (CD79A) binding protein 1 -2.46841
COXFA4 cytochrome c oxidase associated subunit FA4 -2.46371
NPM3 nucleophosmin/nucleoplasmin 3 -2.46126
DEPDC1 DEP domain containing 1 -2.45681
RBMX RNA binding motif protein, X-linked -2.43753
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.4359
KIF14 kinesin family member 14 -2.4305
CDCA3 cell division cycle associated 3 -2.42722
STMN1 stathmin 1 -2.42565
RACGAP1 Rac GTPase activating protein 1 -2.42067
NUSAP1 nucleolar and spindle associated protein 1 -2.4187
EAPP E2F-associated phosphoprotein -2.41408
ZBTB35 zinc finger and BTB domain containing 35 -2.41206
PTTG1 pituitary tumor-transforming 1 -2.39862
GTF2A2 general transcription factor IIA, 2, 12kDa -2.39757
CDKN3 cyclin-dependent kinase inhibitor 3 -2.38213
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.37625
TWNK twinkle mtDNA helicase -2.37015
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.36935
GIN1 gypsy retrotransposon integrase 1 -2.36404
METTL3 methyltransferase like 3 -2.34216
ADSL adenylosuccinate lyase -2.33061
MRPL58 mitochondrial ribosomal protein L58 -2.32435
HJURP Holliday junction recognition protein -2.31562
SNX6 sorting nexin 6 -2.31425
RNFT1-DT RNFT1 divergent transcript -2.31403
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.30614
UQCRC2 ubiquinol-cytochrome c reductase core protein II -2.30434
TMT1A thiol methyltransferase 1A -2.30282
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -2.29995
LBHD1 LBH domain containing 1 -2.29393
EIF3E eukaryotic translation initiation factor 3, subunit E -2.28298
UBL5 ubiquitin-like 5 -2.28286
MNS1 meiosis-specific nuclear structural 1 -2.27427
DBF4 DBF4 zinc finger -2.27067
METTL4 methyltransferase like 4 -2.25603
INTS12 integrator complex subunit 12 -2.25136
RPL10A ribosomal protein L10a -2.24878
ZFAND1 zinc finger, AN1-type domain 1 -2.24483
SPA17 sperm autoantigenic protein 17 -2.24316
TCEAL9 transcription elongation factor A like 9 -2.24293
H2AC25 H2A clustered histone 25 -2.24036
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.23449
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.23412
LETMD1 LETM1 domain containing 1 -2.23255
UIMC1 ubiquitin interaction motif containing 1 -2.23223
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -2.23086
COX7B cytochrome c oxidase subunit VIIb -2.22329
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.21987
NOL11 nucleolar protein 11 -2.21919
SMNDC1 survival motor neuron domain containing 1 -2.20742
CKS1B CDC28 protein kinase regulatory subunit 1B -2.20695
POLR2G polymerase (RNA) II (DNA directed) polypeptide G -2.19521
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.19225
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 -2.1846
GIMAP6 GTPase, IMAP family member 6 -2.18371
PSME3IP1 proteasome activator subunit 3 interacting protein 1 -2.18335
RPS21 ribosomal protein S21 -2.17211
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 -2.17167
TPX2 TPX2, microtubule-associated -2.16636
RPS8 ribosomal protein S8 -2.16629
ZNF862 zinc finger protein 862 -2.16164
TOGARAM1 TOG array regulator of axonemal microtubules 1 -2.14968
TMEM187 transmembrane protein 187 -2.14278
NDC1 NDC1 transmembrane nucleoporin -2.13555
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.13476
SFRP4 secreted frizzled-related protein 4 -2.1345
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.13407
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 -2.12478
ECSIT ECSIT signalling integrator -2.11708
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like -2.10348
KIF18A kinesin family member 18A -2.09617
CCNG1 cyclin G1 -2.09607
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -2.08947
SECTM1 secreted and transmembrane 1 -2.08545
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) -2.07752
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -2.07744
SETMAR SET domain and mariner transposase fusion gene -2.0774
MFAP4 microfibrillar-associated protein 4 -2.07451
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -2.06559
PTPRK protein tyrosine phosphatase, receptor type, K -2.06534
RPA3 replication protein A3, 14kDa -2.065
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.06406
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 -2.05859
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.05822
METTL8 methyltransferase like 8 -2.05818
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) -2.05813
ING4 inhibitor of growth family, member 4 -2.05645
RPP40 ribonuclease P/MRP 40kDa subunit -2.05506
GTPBP8 GTP-binding protein 8 (putative) -2.05442
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 -2.05376
IPCEF1 interaction protein for cytohesin exchange factors 1 -2.04999
GMPR2 guanosine monophosphate reductase 2 -2.04574
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa -2.04415
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.04328
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.04254
CDCA8 cell division cycle associated 8 -2.04072
RPL28 ribosomal protein L28 -2.03833
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) -2.03724
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.02842
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -2.02517
TMEM165 transmembrane protein 165 -2.02497
NIPSNAP2 nipsnap homolog 2 -2.02421
SMIM41 small integral membrane protein 41 -2.02391
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -2.01987
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.00836
PDK4 pyruvate dehydrogenase kinase, isozyme 4 -2.00778
PRKCB protein kinase C, beta -2.00272