CRCGN015_MCF10A_48H:M14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dichloroethane 32.27 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN015_MCF10A_48H:M14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.04633
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.21857
ZW10 zw10 kinetochore protein 3.03086
WIF1 WNT inhibitory factor 1 2.9745
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.96205
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.93888
RNF103-CHMP3 RNF103-CHMP3 readthrough 2.48721
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.41512
TCTA T-cell leukemia translocation altered 2.265
GPN3 GPN-loop GTPase 3 2.09454
CNRIP1 cannabinoid receptor interacting protein 1 2.07753
ZCCHC8 zinc finger, CCHC domain containing 8 2.03942

decreased expression

Symbol Name Standardized Value
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.86263
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.28611
S100A8 S100 calcium binding protein A8 -3.49586
TM9SF3 transmembrane 9 superfamily member 3 -3.18728
CBR1 carbonyl reductase 1 -2.5838
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.52114
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) -2.34211
IGFBP7 insulin-like growth factor binding protein 7 -2.32933
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -2.31726
ATG4A autophagy related 4A, cysteine peptidase -2.30448
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 -2.30175
APOA2 apolipoprotein A-II -2.28528
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.27521
GATA6 GATA binding protein 6 -2.23583
PLK2 polo-like kinase 2 -2.23186
UTRN utrophin -2.16751
SLAMF7 SLAM family member 7 -2.12106
CDCP1 CUB domain containing protein 1 -2.11324
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.07458
PXDC1 PX domain containing 1 -2.04523
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 -2.03608
VIM vimentin -2.00888