CRCGN015_MCF10A_48H:M15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dichloroethane 10.76 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

178 genes differentially expressed following the CRCGN015_MCF10A_48H:M15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZNF318 zinc finger protein 318 4.8459
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 4.72372
ZNF586 zinc finger protein 586 4.52058
CCDC92 coiled-coil domain containing 92 4.37747
GRWD1 glutamate-rich WD repeat containing 1 4.09251
ANO10 anoctamin 10 3.932
CASQ2 calsequestrin 2 (cardiac muscle) 3.70557
FBXL12 F-box and leucine-rich repeat protein 12 3.69708
MEF2C myocyte enhancer factor 2C 3.67133
MYF6 myogenic factor 6 (herculin) 3.34658
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 3.3032
TPM3 tropomyosin 3 3.20236
ZNF134 zinc finger protein 134 3.19423
ACTN2 actinin, alpha 2 3.11803
MAP2K5 mitogen-activated protein kinase kinase 5 3.04061
RBMS3 RNA binding motif, single stranded interacting protein 3 2.97526
CETP cholesteryl ester transfer protein, plasma 2.81984
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.81945
UNC13D unc-13 homolog D (C. elegans) 2.75926
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 2.7424
ASB8 ankyrin repeat and SOCS box containing 8 2.74047
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 2.65464
ZNF672 zinc finger protein 672 2.63263
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 2.62827
ZNF587B zinc finger protein 587B 2.6024
DUSP13A dual specificity phosphatase 13A 2.60057
ZNF211 zinc finger protein 211 2.58407
PLIN3 perilipin 3 2.57667
ARHGAP24 Rho GTPase activating protein 24 2.55753
NOP14 NOP14 nucleolar protein 2.55734
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 2.5493
KRT76 keratin 76, type II 2.5269
ACP6 acid phosphatase 6, lysophosphatidic 2.5257
BTNL8 butyrophilin-like 8 2.52126
MEMO1 mediator of cell motility 1 2.51769
SLC35H1 solute carrier family 35 member H1 2.51527
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.51493
TLR6 toll-like receptor 6 2.4975
RBM14-RBM4 RBM14-RBM4 readthrough 2.49702
GOLGA8A golgin A8 family, member A 2.49049
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 2.48305
RLIM ring finger protein, LIM domain interacting 2.47629
LAGE3 L antigen family, member 3 2.47266
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 2.44486
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.43201
IARS1 isoleucyl-tRNA synthetase 1 2.43071
TLR4 toll-like receptor 4 2.41679
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.40672
CAMKMT calmodulin-lysine N-methyltransferase 2.39376
AGO4 argonaute RISC catalytic component 4 2.38045
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 2.37139
LMO7 LIM domain 7 2.37066
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 2.361
WDR48 WD repeat domain 48 2.34208
UIMC1 ubiquitin interaction motif containing 1 2.33228
MYL2 myosin, light chain 2, regulatory, cardiac, slow 2.31338
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.31041
ZXDC ZXD family zinc finger C 2.3037
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 2.30036
GORASP1 golgi reassembly stacking protein 1, 65kDa 2.28217
TRAT1 T cell receptor associated transmembrane adaptor 1 2.26675
C1QTNF3 C1q and tumor necrosis factor related protein 3 2.25861
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 2.25221
MYOZ2 myozenin 2 2.25059
MYL1 myosin, light chain 1, alkali; skeletal, fast 2.24877
PHF2 PHD finger protein 2 2.24812
PABPC3 poly(A) binding protein, cytoplasmic 3 2.22055
TNNC2 troponin C type 2 (fast) 2.21077
ZNF419 zinc finger protein 419 2.20608
UBIAD1 UbiA prenyltransferase domain containing 1 2.19768
SMPX small muscle protein, X-linked 2.19429
BLM Bloom syndrome, RecQ helicase-like 2.1906
CPEB3 cytoplasmic polyadenylation element binding protein 3 2.16474
ADPRH ADP-ribosylarginine hydrolase 2.15982
CEP350 centrosomal protein 350kDa 2.15389
DDB2 damage-specific DNA binding protein 2, 48kDa 2.15269
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.1471
FAM114A2 family with sequence similarity 114, member A2 2.13337
MYOT myotilin 2.12671
MTTP microsomal triglyceride transfer protein 2.12118
ITGA9 integrin, alpha 9 2.11899
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 2.11255
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 2.10858
FAT4 FAT atypical cadherin 4 2.10607
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 2.0994
CR2 complement component (3d/Epstein Barr virus) receptor 2 2.09587
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.08184
MYL11 myosin light chain 11 2.07706
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 2.07323
FNBP4 formin binding protein 4 2.07022
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 2.06236
DAND5 DAN domain family member 5, BMP antagonist 2.05742
MAPK9 mitogen-activated protein kinase 9 2.05688
TNNI2 troponin I type 2 (skeletal, fast) 2.05519
TNNI1 troponin I type 1 (skeletal, slow) 2.05356
CHAD chondroadherin 2.04889
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) 2.04397
RPH3A rabphilin 3A 2.04109
DKC1 dyskeratosis congenita 1, dyskerin 2.03443
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 2.02851
ATAD2B ATPase family, AAA domain containing 2B 2.027
SCD5 stearoyl-CoA desaturase 5 2.02635
NEK7 NIMA-related kinase 7 2.02327
CKM creatine kinase, muscle 2.01664
MKRN2 makorin ring finger protein 2 2.01287
GDF9 growth differentiation factor 9 2.01278
GTPBP8 GTP-binding protein 8 (putative) 2.01168
ENO3 enolase 3 (beta, muscle) 2.00559
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 2.00394
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 2.00348
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 2.00311
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 2.00019

decreased expression

Symbol Name Standardized Value
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.94076
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.81068
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.70876
ENOPH1 enolase-phosphatase 1 -4.48529
NPDC1 neural proliferation, differentiation and control, 1 -4.36657
CD24 CD24 molecule -3.89162
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.69253
NUPR1 nuclear protein, transcriptional regulator, 1 -3.15731
RNF167 ring finger protein 167 -2.81172
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 -2.77691
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -2.71421
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) -2.69474
GBA1 glucosylceramidase beta 1 -2.69278
DYNLT1 dynein, light chain, Tctex-type 1 -2.68598
AP2S1 adaptor-related protein complex 2, sigma 1 subunit -2.68354
SEPHS2 selenophosphate synthetase 2 -2.68091
RPL39L ribosomal protein L39-like -2.59735
AAMP angio-associated, migratory cell protein -2.5862
PSENEN presenilin enhancer gamma secretase subunit -2.54369
CTSD cathepsin D -2.53394
GUK1 guanylate kinase 1 -2.53033
TSPAN15 tetraspanin 15 -2.52495
ZDHHC4 zinc finger, DHHC-type containing 4 -2.5239
STXBP2 syntaxin binding protein 2 -2.51986
DEF8 differentially expressed in FDCP 8 homolog (mouse) -2.50337
PPDPF pancreatic progenitor cell differentiation and proliferation factor -2.50109
MOSPD3 motile sperm domain containing 3 -2.47354
MPDU1 mannose-P-dolichol utilization defect 1 -2.47001
IFT57 intraflagellar transport 57 -2.40003
PGAP6 post-GPI attachment to proteins 6 -2.37841
ANKMY2 ankyrin repeat and MYND domain containing 2 -2.37676
REEP5 receptor accessory protein 5 -2.36701
C1QA complement component 1, q subcomponent, A chain -2.3641
TMEM176A transmembrane protein 176A -2.27504
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.27394
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 -2.26489
AOC1 amine oxidase, copper containing 1 -2.25437
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -2.25328
EFHC1 EF-hand domain (C-terminal) containing 1 -2.212
TREM2 triggering receptor expressed on myeloid cells 2 -2.20856
CIAO2B cytosolic iron-sulfur assembly component 2B -2.20637
PPP4C protein phosphatase 4, catalytic subunit -2.17593
SELENBP1 selenium binding protein 1 -2.17087
PYCARD PYD and CARD domain containing -2.16637
IL10RA interleukin 10 receptor, alpha -2.15522
TMEM177 transmembrane protein 177 -2.15294
HILPDA hypoxia inducible lipid droplet-associated -2.15149
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) -2.13951
GRN granulin -2.12912
PLVAP plasmalemma vesicle associated protein -2.12735
CDK5 cyclin-dependent kinase 5 -2.12394
MXI1 MAX interactor 1, dimerization protein -2.11875
LITAF lipopolysaccharide-induced TNF factor -2.11421
ANTKMT adenine nucleotide translocase lysine methyltransferase -2.1038
HAAO 3-hydroxyanthranilate 3,4-dioxygenase -2.10309
BEX2 brain expressed X-linked 2 -2.10064
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -2.09115
RNF19B ring finger protein 19B -2.06938
AKIP1 A kinase (PRKA) interacting protein 1 -2.05839
ARMCX1 armadillo repeat containing, X-linked 1 -2.05787
JAG2 jagged 2 -2.05585
SPINT1 serine peptidase inhibitor, Kunitz type 1 -2.04731
WDR13 WD repeat domain 13 -2.03227
MT2A metallothionein 2A -2.0187
C1QB complement component 1, q subcomponent, B chain -2.01528
CBY1 chibby homolog 1 (Drosophila) -2.00295