CRCGN015_MCF10A_48H:M17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cadmium chloride 33.43 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

88 genes differentially expressed following the CRCGN015_MCF10A_48H:M17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 10.0
GLRX glutaredoxin (thioltransferase) 5.01042
TXNRD1 thioredoxin reductase 1 4.7573
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.11755
HBA1 hemoglobin, alpha 1 4.04404
HSPA1A heat shock 70kDa protein 1A 3.2584
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.70884
CRYZ crystallin, zeta (quinone reductase) 2.621
PILRB paired immunoglobin-like type 2 receptor beta 2.5763
TICAM1 toll-like receptor adaptor molecule 1 2.5601
OSTF1 osteoclast stimulating factor 1 2.55275
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 2.53005
PCDHB16 protocadherin beta 16 2.52975
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.5243
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 2.51618
MVP major vault protein 2.4861
LY96 lymphocyte antigen 96 2.4446
SQSTM1 sequestosome 1 2.4351
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 2.38705
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 2.35665
MAPK9 mitogen-activated protein kinase 9 2.35392
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 2.2315
PANK2 pantothenate kinase 2 2.2069
SBNO1 strawberry notch homolog 1 (Drosophila) 2.1708
CENPT centromere protein T 2.15665
CORO1A coronin, actin binding protein, 1A 2.1352
C2CD2 C2 calcium-dependent domain containing 2 2.1066
HTD2 hydroxyacyl-thioester dehydratase type 2 2.08375
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa 2.04265
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 2.0366
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 2.02
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough 2.0186
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 2.01265
MARCO macrophage receptor with collagenous structure 2.0075

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -6.18725
UFM1 ubiquitin-fold modifier 1 -4.9446
COG7 component of oligomeric golgi complex 7 -4.66275
ENOPH1 enolase-phosphatase 1 -4.5613
HEBP1 heme binding protein 1 -4.34015
PROSER1 proline and serine rich 1 -4.2234
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -2.76275
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 -2.68543
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -2.6764
MRPS31 mitochondrial ribosomal protein S31 -2.64965
SAP18 Sin3A-associated protein, 18kDa -2.63515
EXOSC8 exosome component 8 -2.6003
MED4 mediator complex subunit 4 -2.58
MT2A metallothionein 2A -2.5402
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 -2.3991
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) -2.37325
HMGB2 high mobility group box 2 -2.3355
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 -2.3315
MAP3K19 mitogen-activated protein kinase kinase kinase 19 -2.29505
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.2614
SNX17 sorting nexin 17 -2.2279
TOE1 target of EGR1, member 1 (nuclear) -2.22595
MRPL57 mitochondrial ribosomal protein L57 -2.1994
PRMT5 protein arginine methyltransferase 5 -2.1979
SMYD5 SMYD family member 5 -2.1887
MARK3 MAP/microtubule affinity-regulating kinase 3 -2.18635
RFC3 replication factor C (activator 1) 3, 38kDa -2.17015
RBM10 RNA binding motif protein 10 -2.14628
AKAP11 A kinase (PRKA) anchor protein 11 -2.13835
ESD esterase D -2.1276
N4BP2L1 NEDD4 binding protein 2-like 1 -2.11267
RBMX RNA binding motif protein, X-linked -2.107
NEK3 NIMA-related kinase 3 -2.106
CTLA4 cytotoxic T-lymphocyte-associated protein 4 -2.10365
UBL3 ubiquitin-like 3 -2.10363
BZW2 basic leucine zipper and W2 domains 2 -2.1016
LAS1L LAS1-like (S. cerevisiae) -2.0922
HSPH1 heat shock 105kDa/110kDa protein 1 -2.08795
AAAS achalasia, adrenocortical insufficiency, alacrimia -2.0789
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) -2.07695
SELE selectin E -2.07275
GPR52 G protein-coupled receptor 52 -2.065
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -2.0649
KAT8 K(lysine) acetyltransferase 8 -2.0575
TSC22D3 TSC22 domain family, member 3 -2.03212
DOCK1 dedicator of cytokinesis 1 -2.0287
HSPB1 heat shock 27kDa protein 1 -2.02445
HS1BP3 HCLS1 binding protein 3 -2.0202
YBX1 Y box binding protein 1 -2.01818
GPALPP1 GPALPP motifs containing 1 -2.0139
GRWD1 glutamate-rich WD repeat containing 1 -2.01305
GTF3A general transcription factor IIIA -2.01268
TNK1 tyrosine kinase, non-receptor, 1 -2.00885
CENPE centromere protein E, 312kDa -2.0086