CRCGN015_MCF10A_48H:M19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description mestranol 97.87 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

103 genes differentially expressed following the CRCGN015_MCF10A_48H:M19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCP110 centriolar coiled coil protein 110kDa 4.5321
GRB10 growth factor receptor-bound protein 10 4.06035
ZNF589 zinc finger protein 589 4.00618
PRKCQ protein kinase C, theta 3.5518
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 3.20913
SIRT3 sirtuin 3 2.93157
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 2.86606
SNX10 sorting nexin 10 2.74207
PECR peroxisomal trans-2-enoyl-CoA reductase 2.72213
CBX1 chromobox homolog 1 2.58905
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 2.54661
EPHA1 EPH receptor A1 2.50996
DUS2 dihydrouridine synthase 2 2.46721
KYAT1 kynurenine aminotransferase 1 2.46452
RASIP1 Ras interacting protein 1 2.45305
SNX11 sorting nexin 11 2.43694
NUP62CL nucleoporin 62kDa C-terminal like 2.40627
TRDMT1 tRNA aspartic acid methyltransferase 1 2.40583
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 2.36853
THUMPD1 THUMP domain containing 1 2.31609
MTCL1 microtubule crosslinking factor 1 2.25019
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 2.22747
FRMD4B FERM domain containing 4B 2.18943
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.18122
PNPO pyridoxamine 5'-phosphate oxidase 2.17174
GAB2 GRB2-associated binding protein 2 2.15553
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 2.1267
PRMT7 protein arginine methyltransferase 7 2.12641
NAT10 N-acetyltransferase 10 (GCN5-related) 2.05804
SPATA7 spermatogenesis associated 7 2.05466
UEVLD UEV and lactate/malate dehyrogenase domains 2.04672
ETAA1 Ewing tumor-associated antigen 1 2.04159
KIF1B kinesin family member 1B 2.03969
LRRC20 leucine rich repeat containing 20 2.02831
PTBP2 polypyrimidine tract binding protein 2 2.01771
CDK5RAP2 CDK5 regulatory subunit associated protein 2 2.01231
HSPA1A heat shock 70kDa protein 1A 2.00239

decreased expression

Symbol Name Standardized Value
S100A8 S100 calcium binding protein A8 -5.57472
VIM vimentin -5.22263
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.89564
PLK2 polo-like kinase 2 -4.78056
GNAS GNAS complex locus -4.09949
ADI1 acireductone dioxygenase 1 -4.08439
MSMO1 methylsterol monooxygenase 1 -3.77545
RPN2 ribophorin II -3.45247
PABPC1 poly(A) binding protein, cytoplasmic 1 -3.35653
CD58 CD58 molecule -3.27852
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -3.11097
ATP5F1E ATP synthase F1 subunit epsilon -2.92608
CALM2 calmodulin 2 (phosphorylase kinase, delta) -2.80468
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.79621
COX5B cytochrome c oxidase subunit Vb -2.7867
MPC1 mitochondrial pyruvate carrier 1 -2.75777
TMA7 translation machinery associated 7 homolog (S. cerevisiae) -2.68872
TENT5C terminal nucleotidyltransferase 5C -2.68817
SCNN1B sodium channel, non voltage gated 1 beta subunit -2.66546
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -2.65462
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -2.60918
RPL38 ribosomal protein L38 -2.60158
NELFCD negative elongation factor complex member C/D -2.57558
CDK4 cyclin-dependent kinase 4 -2.56876
H3-3A H3.3 histone A -2.54553
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.54015
GTF3A general transcription factor IIIA -2.5045
ISOC1 isochorismatase domain containing 1 -2.47997
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -2.47673
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -2.41035
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -2.35209
AVEN apoptosis, caspase activation inhibitor -2.307
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.3031
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 -2.26887
PABPC3 poly(A) binding protein, cytoplasmic 3 -2.26473
NUTF2 nuclear transport factor 2 -2.25002
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -2.24812
RPL19 ribosomal protein L19 -2.22902
SLC10A3 solute carrier family 10, member 3 -2.2075
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa -2.18529
GOLGA7 golgin A7 -2.17189
TSPAN31 tetraspanin 31 -2.14166
WNT8B wingless-type MMTV integration site family, member 8B -2.13691
CDH18 cadherin 18, type 2 -2.12854
CDH10 cadherin 10, type 2 (T2-cadherin) -2.12295
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal -2.11428
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.10903
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -2.10352
RPL3 ribosomal protein L3 -2.08638
RPS10 ribosomal protein S10 -2.08627
GPX7 glutathione peroxidase 7 -2.08511
EMC7 ER membrane protein complex subunit 7 -2.08478
GDF2 growth differentiation factor 2 -2.07264
CDX2 caudal type homeobox 2 -2.06554
RPL4 ribosomal protein L4 -2.06233
YBX1 Y box binding protein 1 -2.05769
IGFLR1 IGF-like family receptor 1 -2.03833
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin -2.03747
NPPA natriuretic peptide A -2.03456
SPTBN2 spectrin, beta, non-erythrocytic 2 -2.0321
TUBA1C tubulin, alpha 1c -2.03066
MAGEA8 melanoma antigen family A8 -2.02758
HHAT hedgehog acyltransferase -2.01614
ZNF646 zinc finger protein 646 -2.01401
FKBP6 FK506 binding protein 6, 36kDa -2.01021
SOAT2 sterol O-acyltransferase 2 -2.00171