CRCGN015_MCF10A_48H:M20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description mestranol 32.62 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN015_MCF10A_48H:M20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCNF cyclin F 3.54969
CHMP6 charged multivesicular body protein 6 3.48248
GRWD1 glutamate-rich WD repeat containing 1 3.24977
ELAC2 elaC ribonuclease Z 2 3.18343
HBA1 hemoglobin, alpha 1 2.62655
FUZ fuzzy planar cell polarity protein 2.50332
NDE1 nudE neurodevelopment protein 1 2.42193
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.40279
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 2.28606
SIRT3 sirtuin 3 2.26221
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 2.22542
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.16924
CRYBB3 crystallin, beta B3 2.15227
TNRC6B trinucleotide repeat containing 6B 2.05393
PTDSS2 phosphatidylserine synthase 2 2.03938
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 2.02643
TCF15 transcription factor 15 (basic helix-loop-helix) 2.01663

decreased expression

Symbol Name Standardized Value
CHMP4B charged multivesicular body protein 4B -4.39039
MT2A metallothionein 2A -4.12142
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.98414
TMEM147 transmembrane protein 147 -2.82067
TBCB tubulin folding cofactor B -2.59235
MAPK13 mitogen-activated protein kinase 13 -2.51966
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.35224
KRT34 keratin 34, type I -2.31881
MNT MAX network transcriptional repressor -2.26041
TXNRD1 thioredoxin reductase 1 -2.18107
RBM42 RNA binding motif protein 42 -2.1403
CANT1 calcium activated nucleotidase 1 -2.13604
SMG8 SMG8 nonsense mediated mRNA decay factor -2.08007
SAMD9 sterile alpha motif domain containing 9 -2.06584
GLOD4 glyoxalase domain containing 4 -2.03896
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -2.0369