CRCGN015_MCF10A_48H:M23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-nitropyrene 33.98 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

608 genes differentially expressed following the CRCGN015_MCF10A_48H:M23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 6.14694
DDB2 damage-specific DNA binding protein 2, 48kDa 5.96941
WIF1 WNT inhibitory factor 1 5.30636
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 5.26779
MYL9 myosin, light chain 9, regulatory 5.24586
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.06291
RGS2 regulator of G-protein signaling 2 5.06182
INPP1 inositol polyphosphate-1-phosphatase 4.98238
FHL2 four and a half LIM domains 2 4.92698
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.76816
SESN1 sestrin 1 4.74716
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.12612
FDXR ferredoxin reductase 4.11274
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.07513
PDLIM1 PDZ and LIM domain 1 4.06263
RAP1GAP2 RAP1 GTPase activating protein 2 3.98602
TERF2IP telomeric repeat binding factor 2, interacting protein 3.97462
PHLDA3 pleckstrin homology-like domain, family A, member 3 3.91118
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 3.85631
IL4R interleukin 4 receptor 3.82188
KLHL21 kelch-like family member 21 3.80485
GABARAPL1 GABA(A) receptor-associated protein like 1 3.79372
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.74231
NISCH nischarin 3.49161
LRP10 low density lipoprotein receptor-related protein 10 3.47698
FAT1 FAT atypical cadherin 1 3.43541
TCEAL4 transcription elongation factor A (SII)-like 4 3.33823
IP6K2 inositol hexakisphosphate kinase 2 3.32869
CALCOCO1 calcium binding and coiled-coil domain 1 3.30031
MBD1 methyl-CpG binding domain protein 1 3.2917
AEN apoptosis enhancing nuclease 3.28514
ATF3 activating transcription factor 3 3.28186
NFS1 NFS1 cysteine desulfurase 3.27399
TRIM22 tripartite motif containing 22 3.27159
TUFT1 tuftelin 1 3.2695
ITPKC inositol-trisphosphate 3-kinase C 3.20769
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 3.17045
ACTA2 actin, alpha 2, smooth muscle, aorta 3.08605
ZNF212 zinc finger protein 212 3.084
TMEM40 transmembrane protein 40 3.08103
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 3.05087
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.95162
CSRNP2 cysteine-serine-rich nuclear protein 2 2.94845
ANXA8L1 annexin A8-like 1 2.94465
BLCAP bladder cancer associated protein 2.9397
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 2.93566
ERCC3 excision repair cross-complementation group 3 2.92709
SSH3 slingshot protein phosphatase 3 2.91853
DYNLT3 dynein, light chain, Tctex-type 3 2.91172
SKIC2 SKI2 subunit of superkiller complex 2.87235
TXLNA taxilin alpha 2.87062
H2BC21 H2B clustered histone 21 2.81886
KIF3B kinesin family member 3B 2.79412
ZFC3H1 zinc finger, C3H1-type containing 2.79383
GDF15 growth differentiation factor 15 2.77627
INPPL1 inositol polyphosphate phosphatase-like 1 2.75862
BICRA BRD4 interacting chromatin remodeling complex associated protein 2.73036
GDI1 GDP dissociation inhibitor 1 2.72916
TMEM134 transmembrane protein 134 2.72049
DUSP8 dual specificity phosphatase 8 2.71102
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 2.69749
LSP1 lymphocyte-specific protein 1 2.69596
CAMTA2 calmodulin binding transcription activator 2 2.69359
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.67815
ZNF79 zinc finger protein 79 2.67433
TRIB1 tribbles pseudokinase 1 2.67352
UBXN6 UBX domain protein 6 2.66367
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 2.66271
TIGAR TP53 induced glycolysis regulatory phosphatase 2.65649
EPHA2 EPH receptor A2 2.649
PLK3 polo-like kinase 3 2.64115
ZNF692 zinc finger protein 692 2.6256
CCDC92 coiled-coil domain containing 92 2.6166
NBEAL2 neurobeachin-like 2 2.60245
CBR4 carbonyl reductase 4 2.60209
CDIP1 cell death-inducing p53 target 1 2.59555
TFE3 transcription factor binding to IGHM enhancer 3 2.58665
GPR87 G protein-coupled receptor 87 2.58258
FBXO2 F-box protein 2 2.5653
TEX14 testis expressed 14 2.56058
MXD4 MAX dimerization protein 4 2.55917
FAM53C family with sequence similarity 53, member C 2.55887
CDK5RAP1 CDK5 regulatory subunit associated protein 1 2.55873
PLEK pleckstrin 2.55581
CIC capicua transcriptional repressor 2.55577
ARMCX3 armadillo repeat containing, X-linked 3 2.5538
LIF leukemia inhibitory factor 2.54176
RGL2 ral guanine nucleotide dissociation stimulator-like 2 2.53518
KDM5C lysine (K)-specific demethylase 5C 2.53372
TOMM34 translocase of outer mitochondrial membrane 34 2.51719
OPLAH 5-oxoprolinase (ATP-hydrolysing) 2.51503
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.50363
ZNF446 zinc finger protein 446 2.50151
BECN1 beclin 1, autophagy related 2.50045
HDLBP high density lipoprotein binding protein 2.49677
AMOTL2 angiomotin like 2 2.4849
STAMBP STAM binding protein 2.4818
ORAI3 ORAI calcium release-activated calcium modulator 3 2.47855
CEL carboxyl ester lipase 2.46792
TBK1 TANK-binding kinase 1 2.46045
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.44051
DNASE1L1 deoxyribonuclease I-like 1 2.4339
EPS8L2 EPS8-like 2 2.43365
ULK1 unc-51 like autophagy activating kinase 1 2.42341
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 2.42132
ZC3H12A zinc finger CCCH-type containing 12A 2.41754
GSAP gamma-secretase activating protein 2.41368
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 2.41097
RBM41 RNA binding motif protein 41 2.40961
ATOSB atos homolog B 2.40848
HLA-C major histocompatibility complex, class I, C 2.39928
PHKA2 phosphorylase kinase, alpha 2 (liver) 2.3977
ZNF562 zinc finger protein 562 2.38861
RAB4B RAB4B, member RAS oncogene family 2.38658
BSDC1 BSD domain containing 1 2.38546
XYLT2 xylosyltransferase II 2.38322
ATG2A autophagy related 2A 2.38283
IRF6 interferon regulatory factor 6 2.38234
CHIC2 cysteine-rich hydrophobic domain 2 2.38221
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 2.38068
FHIP2B FHF complex subunit HOOK interacting protein 2B 2.3805
NCDN neurochondrin 2.37975
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 2.37974
PTPRE protein tyrosine phosphatase, receptor type, E 2.37787
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 2.37782
BTG2 BTG family, member 2 2.37314
GMEB2 glucocorticoid modulatory element binding protein 2 2.37094
SEC31B SEC31 homolog B (S. cerevisiae) 2.36498
NIT1 nitrilase 1 2.34035
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 2.33999
TSPYL2 TSPY-like 2 2.32926
CRELD1 cysteine-rich with EGF-like domains 1 2.32884
ARID5B AT rich interactive domain 5B (MRF1-like) 2.32848
RNF10 ring finger protein 10 2.32828
EDN1 endothelin 1 2.32078
MAPKBP1 mitogen-activated protein kinase binding protein 1 2.31109
LY6G6F-LY6G6D LY6G6F-LY6G6D readthrough 2.30829
UBAP1 ubiquitin associated protein 1 2.30268
TICAM1 toll-like receptor adaptor molecule 1 2.30088
GRN granulin 2.30009
MAP3K14 mitogen-activated protein kinase kinase kinase 14 2.28039
ZNF324 zinc finger protein 324 2.27588
CREB5 cAMP responsive element binding protein 5 2.27561
OSBPL2 oxysterol binding protein-like 2 2.27451
EOLA1 endothelium and lymphocyte associated ASCH domain 1 2.26687
YPEL5 yippee-like 5 (Drosophila) 2.26498
DMWD dystrophia myotonica, WD repeat containing 2.25899
SDC4 syndecan 4 2.25174
STK38L serine/threonine kinase 38 like 2.24905
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 2.2482
GADD45A growth arrest and DNA-damage-inducible, alpha 2.24762
PIGG phosphatidylinositol glycan anchor biosynthesis, class G 2.24172
ZIM3 zinc finger, imprinted 3 2.24149
ARID3B AT rich interactive domain 3B (BRIGHT-like) 2.23521
TOP1 topoisomerase (DNA) I 2.23511
YIPF3 Yip1 domain family, member 3 2.23167
KEAP1 kelch-like ECH-associated protein 1 2.22902
FBXL12 F-box and leucine-rich repeat protein 12 2.22579
GOLGB1 golgin B1 2.2252
DKK3 dickkopf WNT signaling pathway inhibitor 3 2.22514
CHPF2 chondroitin polymerizing factor 2 2.22461
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 2.22257
RAB11FIP5 RAB11 family interacting protein 5 (class I) 2.22051
GTF2B general transcription factor IIB 2.22007
PICK1 protein interacting with PRKCA 1 2.21893
ECH1 enoyl CoA hydratase 1, peroxisomal 2.21211
AGAP4 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 2.21107
PCGF3 polycomb group ring finger 3 2.21009
H2AC6 H2A clustered histone 6 2.20905
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2.20645
ZNF671 zinc finger protein 671 2.20308
ELMO2 engulfment and cell motility 2 2.20087
HDAC7 histone deacetylase 7 2.19414
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.18947
PLD3 phospholipase D family, member 3 2.18833
CYB5R2 cytochrome b5 reductase 2 2.17714
ATG4B autophagy related 4B, cysteine peptidase 2.17486
PRKX protein kinase, X-linked 2.16451
TUBG2 tubulin, gamma 2 2.16305
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 2.16179
SPATA20 spermatogenesis associated 20 2.16163
PERP PERP, TP53 apoptosis effector 2.15941
AP1G2 adaptor-related protein complex 1, gamma 2 subunit 2.1587
MYD88 myeloid differentiation primary response 88 2.15675
EHD1 EH-domain containing 1 2.15465
IDUA iduronidase, alpha-L- 2.15351
FAM168B family with sequence similarity 168, member B 2.15279
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.14966
RMC1 regulator of MON1-CCZ1 2.14808
PLXNB2 plexin B2 2.14716
GAK cyclin G associated kinase 2.14553
BBS1 Bardet-Biedl syndrome 1 2.14389
FILIP1L filamin A interacting protein 1-like 2.14135
LOC122526780 uncharacterized LOC122526780 2.14061
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit 2.1401
ACTMAP actin maturation protease 2.13967
CAPN10 calpain 10 2.13729
G0S2 G0/G1 switch 2 2.13694
CLTB clathrin, light chain B 2.1365
PCNP PEST proteolytic signal containing nuclear protein 2.13551
GPR153 G protein-coupled receptor 153 2.1338
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.13103
EHD3 EH-domain containing 3 2.13034
SHARPIN SHANK-associated RH domain interactor 2.12976
ZNF219 zinc finger protein 219 2.12946
ACADVL acyl-CoA dehydrogenase, very long chain 2.12939
BCORL1 BCL6 corepressor-like 1 2.1245
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 2.11931
PNKP polynucleotide kinase 3'-phosphatase 2.1182
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 2.11623
SETD1A SET domain containing 1A 2.11596
OPTN optineurin 2.11443
IER5 immediate early response 5 2.11321
ZNF548 zinc finger protein 548 2.11085
OFD1 oral-facial-digital syndrome 1 2.11071
SOX4 SRY (sex determining region Y)-box 4 2.10884
CLBA1 clathrin binding box of aftiphilin containing 1 2.10563
GPR143 G protein-coupled receptor 143 2.10536
CHD8 chromodomain helicase DNA binding protein 8 2.1052
STK25 serine/threonine kinase 25 2.10235
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.10046
FAN1 FANCD2/FANCI-associated nuclease 1 2.09845
RAB21 RAB21, member RAS oncogene family 2.0931
GALNS galactosamine (N-acetyl)-6-sulfatase 2.0931
LUZP1 leucine zipper protein 1 2.0883
NSG1 neuron specific gene family member 1 2.08756
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.08647
CRLF2 cytokine receptor-like factor 2 2.08461
CTF1 cardiotrophin 1 2.08122
IFI27 interferon, alpha-inducible protein 27 2.07995
CIRBP cold inducible RNA binding protein 2.07972
CDC16 cell division cycle 16 2.07739
RNF44 ring finger protein 44 2.0759
PI4K2A phosphatidylinositol 4-kinase type 2 alpha 2.07535
PLCH2 phospholipase C, eta 2 2.0705
PIWIL2 piwi-like RNA-mediated gene silencing 2 2.06951
BCL2L2 BCL2-like 2 2.0682
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 2.0654
PGF placental growth factor 2.06502
ZMAT3 zinc finger, matrin-type 3 2.0613
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 2.06122
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.06069
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 2.05857
KIF13B kinesin family member 13B 2.05829
ISCU iron-sulfur cluster assembly enzyme 2.0546
INTS3 integrator complex subunit 3 2.05405
CPEB1 cytoplasmic polyadenylation element binding protein 1 2.05394
TMEM59 transmembrane protein 59 2.05296
SPATA2 spermatogenesis associated 2 2.05242
PELI1 pellino E3 ubiquitin protein ligase 1 2.04993
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 2.04769
ERCC5 excision repair cross-complementation group 5 2.0474
REC8 REC8 meiotic recombination protein 2.04467
GAA glucosidase, alpha; acid 2.04344
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 2.04105
PXDC1 PX domain containing 1 2.03938
CCS copper chaperone for superoxide dismutase 2.03926
TNIP2 TNFAIP3 interacting protein 2 2.03739
AICDA activation-induced cytidine deaminase 2.03493
SPAG16 sperm associated antigen 16 2.03251
ZNF211 zinc finger protein 211 2.03186
KIAA1614 KIAA1614 2.03119
MOSPD1 motile sperm domain containing 1 2.03021
FAM131A family with sequence similarity 131, member A 2.02842
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 2.02776
SGSM2 small G protein signaling modulator 2 2.02722
PGPEP1 pyroglutamyl-peptidase I 2.02661
SERTAD3 SERTA domain containing 3 2.02641
CUL7 cullin 7 2.01483
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 2.0142
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 2.00615
DUSP14 dual specificity phosphatase 14 2.00255
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 2.00104

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -7.29439
CCNB2 cyclin B2 -5.51481
CDK1 cyclin-dependent kinase 1 -5.32029
CCNA2 cyclin A2 -5.3051
TOP2A topoisomerase (DNA) II alpha 170kDa -5.02313
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -4.8351
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -4.78865
KIF14 kinesin family member 14 -4.6572
MELK maternal embryonic leucine zipper kinase -4.55495
PLK1 polo-like kinase 1 -4.4778
DCK deoxycytidine kinase -4.45272
NUSAP1 nucleolar and spindle associated protein 1 -4.42754
DEPDC1 DEP domain containing 1 -4.36712
HJURP Holliday junction recognition protein -4.32521
BIRC5 baculoviral IAP repeat containing 5 -4.31084
SPC25 SPC25, NDC80 kinetochore complex component -4.29208
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -4.27211
TTK TTK protein kinase -4.2664
ATAD2 ATPase family, AAA domain containing 2 -4.15937
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -4.12999
ELOVL6 ELOVL fatty acid elongase 6 -4.0313
KIF4A kinesin family member 4A -4.01745
CDC25B cell division cycle 25B -4.0111
MCM10 minichromosome maintenance complex component 10 -3.99496
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.90714
GPHN gephyrin -3.88543
CENPN centromere protein N -3.87222
CENPA centromere protein A -3.86018
NEK2 NIMA-related kinase 2 -3.858
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.84547
STMN1 stathmin 1 -3.84435
KIF18A kinesin family member 18A -3.8168
PBK PDZ binding kinase -3.80604
DDIT4 DNA-damage-inducible transcript 4 -3.78524
GINS2 GINS complex subunit 2 (Psf2 homolog) -3.74448
CDCA3 cell division cycle associated 3 -3.71227
PARP1 poly (ADP-ribose) polymerase 1 -3.70033
OIP5 Opa interacting protein 5 -3.69843
PTGES3 prostaglandin E synthase 3 (cytosolic) -3.68121
MCM6 minichromosome maintenance complex component 6 -3.67578
CDKN3 cyclin-dependent kinase inhibitor 3 -3.66609
HMGB2 high mobility group box 2 -3.65913
TPX2 TPX2, microtubule-associated -3.61549
TRIP13 thyroid hormone receptor interactor 13 -3.56902
CD58 CD58 molecule -3.5516
EXO1 exonuclease 1 -3.53427
HMMR hyaluronan-mediated motility receptor (RHAMM) -3.52837
PIMREG PICALM interacting mitotic regulator -3.52274
MANEA mannosidase, endo-alpha -3.47003
KIF15 kinesin family member 15 -3.45183
RACGAP1 Rac GTPase activating protein 1 -3.43751
COG7 component of oligomeric golgi complex 7 -3.39055
KIF23 kinesin family member 23 -3.38647
UBE2C ubiquitin-conjugating enzyme E2C -3.3404
ERCC6L excision repair cross-complementation group 6-like -3.34032
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) -3.31509
RRM2 ribonucleotide reductase M2 -3.30558
PRC1 protein regulator of cytokinesis 1 -3.2757
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.26678
FBXO5 F-box protein 5 -3.25822
PSRC1 proline/serine-rich coiled-coil 1 -3.21201
MKI67 marker of proliferation Ki-67 -3.20813
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -3.20494
KIF11 kinesin family member 11 -3.19805
LMNB1 lamin B1 -3.18966
KIF20A kinesin family member 20A -3.1786
NCAPH non-SMC condensin I complex, subunit H -3.15296
CENPU centromere protein U -3.12772
CDC25C cell division cycle 25C -3.11827
PARPBP PARP1 binding protein -3.10497
EXOC5 exocyst complex component 5 -3.10481
CDC45 cell division cycle 45 -3.09823
TMEM38B transmembrane protein 38B -3.05803
GABPA GA binding protein transcription factor, alpha subunit 60kDa -3.04016
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -3.03214
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -3.02284
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -3.02051
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.01898
CHEK1 checkpoint kinase 1 -3.00607
CREG1 cellular repressor of E1A-stimulated genes 1 -2.95166
PTTG1 pituitary tumor-transforming 1 -2.94897
CENPX centromere protein X -2.94835
HOXB9 homeobox B9 -2.93679
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.93438
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.92376
FXN frataxin -2.91764
RPS5 ribosomal protein S5 -2.91345
RAB23 RAB23, member RAS oncogene family -2.91174
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.90281
NCAPG2 non-SMC condensin II complex, subunit G2 -2.90025
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -2.89629
MIS18A MIS18 kinetochore protein A -2.88732
TIPIN TIMELESS interacting protein -2.88083
VRK1 vaccinia related kinase 1 -2.87456
PLK4 polo-like kinase 4 -2.87043
LBR lamin B receptor -2.8692
CENPF centromere protein F, 350/400kDa -2.86794
CDCA8 cell division cycle associated 8 -2.86125
EML4 echinoderm microtubule associated protein like 4 -2.86064
PGM1 phosphoglucomutase 1 -2.858
TSPAN3 tetraspanin 3 -2.84417
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.81743
MCM4 minichromosome maintenance complex component 4 -2.81614
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.8074
VDAC1 voltage-dependent anion channel 1 -2.8065
ALG3 ALG3, alpha-1,3- mannosyltransferase -2.803
CCNB1 cyclin B1 -2.79323
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.79197
MSRA methionine sulfoxide reductase A -2.78876
TMPO thymopoietin -2.78613
H2AZ1 H2A.Z variant histone 1 -2.78369
ZWINT ZW10 interacting kinetochore protein -2.77562
WDHD1 WD repeat and HMG-box DNA binding protein 1 -2.77207
SKA1 spindle and kinetochore associated complex subunit 1 -2.75199
CISD1 CDGSH iron sulfur domain 1 -2.73476
TACC3 transforming, acidic coiled-coil containing protein 3 -2.73411
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.73143
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.72152
HMGB1 high mobility group box 1 -2.71517
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.71442
KIAA0586 KIAA0586 -2.70566
MRPL35 mitochondrial ribosomal protein L35 -2.69808
FOXM1 forkhead box M1 -2.69056
CENPM centromere protein M -2.68793
CD96 CD96 molecule -2.68311
ZMYM1 zinc finger, MYM-type 1 -2.66004
SPAG5 sperm associated antigen 5 -2.63828
RFC3 replication factor C (activator 1) 3, 38kDa -2.63323
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 -2.63049
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -2.62909
NDC80 NDC80 kinetochore complex component -2.61743
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -2.60496
GCSH glycine cleavage system protein H (aminomethyl carrier) -2.60295
SLC25A40 solute carrier family 25, member 40 -2.60059
DHFR dihydrofolate reductase -2.60036
NDC1 NDC1 transmembrane nucleoporin -2.59993
HMGN4 high mobility group nucleosomal binding domain 4 -2.59738
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -2.58571
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent -2.58295
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.57274
FANCI Fanconi anemia, complementation group I -2.56774
EPHB2 EPH receptor B2 -2.56704
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -2.56548
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.56495
RB1 retinoblastoma 1 -2.55312
MAPK1 mitogen-activated protein kinase 1 -2.5504
TMEM267 transmembrane protein 267 -2.54175
GEMIN2 gem (nuclear organelle) associated protein 2 -2.54012
BRCA1 breast cancer 1, early onset -2.53946
CLIC4 chloride intracellular channel 4 -2.53265
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) -2.5323
CEP55 centrosomal protein 55kDa -2.52883
FAM216A family with sequence similarity 216, member A -2.52728
CALU calumenin -2.51889
ADI1 acireductone dioxygenase 1 -2.51877
SNRPA small nuclear ribonucleoprotein polypeptide A -2.51343
ZWILCH zwilch kinetochore protein -2.49233
DMAC2L distal membrane arm assembly component 2 like -2.48448
CENPE centromere protein E, 312kDa -2.48411
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -2.48251
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.48227
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -2.47997
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -2.47163
RMI1 RecQ mediated genome instability 1 -2.4715
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -2.4699
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) -2.46506
RBMX RNA binding motif protein, X-linked -2.46355
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.46302
MCM3 minichromosome maintenance complex component 3 -2.45641
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.45294
PHOSPHO2-KLHL23 PHOSPHO2-KLHL23 readthrough -2.45293
IPO5 importin 5 -2.44655
XYLT1 xylosyltransferase I -2.43889
RNF144A ring finger protein 144A -2.43509
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 -2.435
MCM5 minichromosome maintenance complex component 5 -2.43041
AGPS alkylglycerone phosphate synthase -2.42915
CKS2 CDC28 protein kinase regulatory subunit 2 -2.42683
CENPI centromere protein I -2.42592
PRSS2 protease, serine, 2 (trypsin 2) -2.42538
DBF4 DBF4 zinc finger -2.42373
NUP37 nucleoporin 37kDa -2.40846
ARHGAP11A Rho GTPase activating protein 11A -2.40843
TMEM123 transmembrane protein 123 -2.40475
OXCT1 3-oxoacid CoA transferase 1 -2.40312
SMC4 structural maintenance of chromosomes 4 -2.39219
PDK4 pyruvate dehydrogenase kinase, isozyme 4 -2.3919
IARS1 isoleucyl-tRNA synthetase 1 -2.38876
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -2.38823
ASF1B anti-silencing function 1B histone chaperone -2.38597
CKS1B CDC28 protein kinase regulatory subunit 1B -2.37536
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -2.35871
IPO7 importin 7 -2.34073
COLGALT1 collagen beta(1-O)galactosyltransferase 1 -2.33948
HSPA8 heat shock 70kDa protein 8 -2.339
CKAP2 cytoskeleton associated protein 2 -2.33582
TMX1 thioredoxin-related transmembrane protein 1 -2.33317
CSRP2 cysteine and glycine-rich protein 2 -2.32752
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -2.32618
CDK4 cyclin-dependent kinase 4 -2.32304
CDC6 cell division cycle 6 -2.32055
RPP40 ribonuclease P/MRP 40kDa subunit -2.32004
SHCBP1 SHC SH2-domain binding protein 1 -2.31798
PCLAF PCNA clamp associated factor -2.30975
BCAP29 B-cell receptor-associated protein 29 -2.29967
BORA bora, aurora kinase A activator -2.29695
RBBP4 retinoblastoma binding protein 4 -2.29426
PHTF2 putative homeodomain transcription factor 2 -2.28955
MRPL12 mitochondrial ribosomal protein L12 -2.28858
NTAQ1 N-terminal glutamine amidase 1 -2.28577
NAV3 neuron navigator 3 -2.28572
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.28538
VPS26C VPS26 endosomal protein sorting factor C -2.27026
RPRD1A regulation of nuclear pre-mRNA domain containing 1A -2.26996
BFAR bifunctional apoptosis regulator -2.26754
FOXN2 forkhead box N2 -2.26619
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -2.26574
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) -2.26248
WDR12 WD repeat domain 12 -2.25856
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -2.25759
POLR1F RNA polymerase I subunit F -2.25102
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.24947
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -2.24872
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -2.2465
BOP1 block of proliferation 1 -2.24366
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C -2.24148
DONSON downstream neighbor of SON -2.23456
NUBP2 nucleotide binding protein 2 -2.22982
EIPR1 EARP complex and GARP complex interacting protein 1 -2.22536
RANBP1 RAN binding protein 1 -2.22199
PHGDH phosphoglycerate dehydrogenase -2.22041
RHOBTB3 Rho-related BTB domain containing 3 -2.21917
SORD sorbitol dehydrogenase -2.21619
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.2103
MCM7 minichromosome maintenance complex component 7 -2.21
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 -2.20626
FXYD5 FXYD domain containing ion transport regulator 5 -2.20597
ATF6 activating transcription factor 6 -2.20554
RPA3 replication protein A3, 14kDa -2.2054
UBIAD1 UbiA prenyltransferase domain containing 1 -2.19908
CDK2 cyclin-dependent kinase 2 -2.19243
C1QBP complement component 1, q subcomponent binding protein -2.19032
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.18819
KIF18B kinesin family member 18B -2.18549
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -2.18025
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -2.17932
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.1782
PSAT1 phosphoserine aminotransferase 1 -2.17435
PWP1 PWP1 homolog (S. cerevisiae) -2.17288
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 -2.1722
GUF1 GUF1 GTPase homolog (S. cerevisiae) -2.16131
CYCS cytochrome c, somatic -2.15332
IQGAP2 IQ motif containing GTPase activating protein 2 -2.15177
SCYL2 SCY1-like 2 (S. cerevisiae) -2.14759
SLC35F2 solute carrier family 35, member F2 -2.14723
HPRT1 hypoxanthine phosphoribosyltransferase 1 -2.14579
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 -2.14177
SEC13 SEC13 homolog (S. cerevisiae) -2.13938
PAGR1 PAXIP1 associated glutamate-rich protein 1 -2.13524
PCDHGA3 protocadherin gamma subfamily A, 3 -2.13222
STX17 syntaxin 17 -2.12838
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.12785
SIGMAR1 sigma non-opioid intracellular receptor 1 -2.1261
AURKA aurora kinase A -2.12481
USP39 ubiquitin specific peptidase 39 -2.12178
RAB5C RAB5C, member RAS oncogene family -2.11899
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -2.1189
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -2.11848
MCMBP minichromosome maintenance complex binding protein -2.11771
GDI2 GDP dissociation inhibitor 2 -2.11541
ATG5 autophagy related 5 -2.11369
FKBP5 FK506 binding protein 5 -2.11246
NQO1 NAD(P)H dehydrogenase, quinone 1 -2.11225
CPAP centrosome assembly and centriole elongation protein -2.11204
NFIL3 nuclear factor, interleukin 3 regulated -2.11178
DSCC1 DNA replication and sister chromatid cohesion 1 -2.11112
TMEM100 transmembrane protein 100 -2.10921
CAVIN2 caveolae associated protein 2 -2.10707
TMEM109 transmembrane protein 109 -2.10683
TMEM209 transmembrane protein 209 -2.10676
NUP205 nucleoporin 205kDa -2.10661
CASP8AP2 caspase 8 associated protein 2 -2.10477
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) -2.10352
PDE3B phosphodiesterase 3B, cGMP-inhibited -2.09488
TDP1 tyrosyl-DNA phosphodiesterase 1 -2.09312
NCAPG non-SMC condensin I complex, subunit G -2.09251
GLRX5 glutaredoxin 5 -2.0893
GTF2A2 general transcription factor IIA, 2, 12kDa -2.08926
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -2.0867
LMAN1 lectin, mannose-binding, 1 -2.08663
MPZL1 myelin protein zero-like 1 -2.08578
ZNF428 zinc finger protein 428 -2.08541
CHURC1-FNTB CHURC1-FNTB readthrough -2.0854
RBM28 RNA binding motif protein 28 -2.08288
PEBP1 phosphatidylethanolamine binding protein 1 -2.08212
RPL26L1 ribosomal protein L26-like 1 -2.08046
SOX11 SRY (sex determining region Y)-box 11 -2.0801
SP8 Sp8 transcription factor -2.07881
TMEM50B transmembrane protein 50B -2.07657
ANAPC10 anaphase promoting complex subunit 10 -2.07039
TCTA T-cell leukemia translocation altered -2.06996
CBR3 carbonyl reductase 3 -2.05771
CORO1C coronin, actin binding protein, 1C -2.05447
ANAPC15 anaphase promoting complex subunit 15 -2.04596
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.04525
DEK DEK proto-oncogene -2.03715
ADAM15 ADAM metallopeptidase domain 15 -2.03641
TMEM135 transmembrane protein 135 -2.03615
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) -2.03535
CCNF cyclin F -2.03474
CDK6 cyclin-dependent kinase 6 -2.03376
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.03281
KCTD20 potassium channel tetramerization domain containing 20 -2.03206
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -2.03084
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -2.03003
UNG uracil-DNA glycosylase -2.03003
ENO1 enolase 1, (alpha) -2.02731
SMYD5 SMYD family member 5 -2.02563
STIL SCL/TAL1 interrupting locus -2.02438
PRKDC protein kinase, DNA-activated, catalytic polypeptide -2.023
NUP93 nucleoporin 93kDa -2.02075
RNF130 ring finger protein 130 -2.02066
GPSM2 G-protein signaling modulator 2 -2.01809
SSBP2 single-stranded DNA binding protein 2 -2.01785
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.01653
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) -2.01577
BIRC2 baculoviral IAP repeat containing 2 -2.01395
CRLF3 cytokine receptor-like factor 3 -2.01263
PRMT1 protein arginine methyltransferase 1 -2.01123
TK1 thymidine kinase 1, soluble -2.00849
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) -2.00781
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.00716
NCOA3 nuclear receptor coactivator 3 -2.00575
SRSF3 serine/arginine-rich splicing factor 3 -2.00564
CEP83 centrosomal protein 83kDa -2.00439