CRCGN015_MCF10A_48H:N12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetranitromethane 11.26 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

135 genes differentially expressed following the CRCGN015_MCF10A_48H:N12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 4.44603
CDPF1 cysteine-rich, DPF motif domain containing 1 3.21049
TRIM22 tripartite motif containing 22 2.56527
MSRA methionine sulfoxide reductase A 2.5019
CIRBP cold inducible RNA binding protein 2.46365
MUC1 mucin 1, cell surface associated 2.40627
EPN2 epsin 2 2.36884
AP1M2 adaptor-related protein complex 1, mu 2 subunit 2.23975
PRR15L proline rich 15-like 2.23254
CALCOCO1 calcium binding and coiled-coil domain 1 2.21286
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 2.17377
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) 2.11891
TRIM38 tripartite motif containing 38 2.11612
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.10134
GOLGB1 golgin B1 2.09013
TTC17 tetratricopeptide repeat domain 17 2.08389
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 2.07732
REL v-rel avian reticuloendotheliosis viral oncogene homolog 2.06878
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2.06104
SECTM1 secreted and transmembrane 1 2.05293
NPDC1 neural proliferation, differentiation and control, 1 2.00387

decreased expression

Symbol Name Standardized Value
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -4.10826
CDC20 cell division cycle 20 -4.01622
CDK4 cyclin-dependent kinase 4 -4.01585
KIF11 kinesin family member 11 -3.58875
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -3.56444
UBE2C ubiquitin-conjugating enzyme E2C -3.52522
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.52026
CCNB2 cyclin B2 -3.5095
RFC4 replication factor C (activator 1) 4, 37kDa -3.48218
EXO1 exonuclease 1 -3.42669
TOP2A topoisomerase (DNA) II alpha 170kDa -3.42348
CENPU centromere protein U -3.38217
CCNA2 cyclin A2 -3.21641
NCAPG2 non-SMC condensin II complex, subunit G2 -3.1684
MCM6 minichromosome maintenance complex component 6 -3.16803
H2AZ1 H2A.Z variant histone 1 -3.16469
PCNA proliferating cell nuclear antigen -3.14108
MAPK13 mitogen-activated protein kinase 13 -3.12311
ZWINT ZW10 interacting kinetochore protein -3.12146
GINS2 GINS complex subunit 2 (Psf2 homolog) -3.11969
MELK maternal embryonic leucine zipper kinase -3.10521
BIRC5 baculoviral IAP repeat containing 5 -3.09717
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.01671
PLK1 polo-like kinase 1 -2.97783
HMGB2 high mobility group box 2 -2.93699
HJURP Holliday junction recognition protein -2.93473
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.92335
KIF4A kinesin family member 4A -2.91937
CDK1 cyclin-dependent kinase 1 -2.91662
CDC45 cell division cycle 45 -2.91384
CDC6 cell division cycle 6 -2.87221
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.7519
PBK PDZ binding kinase -2.74841
CCNH cyclin H -2.74556
FANCI Fanconi anemia, complementation group I -2.7391
LBR lamin B receptor -2.73534
SPAG5 sperm associated antigen 5 -2.69368
DBF4 DBF4 zinc finger -2.67585
FBXO5 F-box protein 5 -2.67134
EXOSC8 exosome component 8 -2.66554
KIF14 kinesin family member 14 -2.65053
CDCA8 cell division cycle associated 8 -2.63914
STMN1 stathmin 1 -2.63855
TIPIN TIMELESS interacting protein -2.6263
HMGA2 high mobility group AT-hook 2 -2.62594
MCM10 minichromosome maintenance complex component 10 -2.61244
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.60949
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.58082
USP1 ubiquitin specific peptidase 1 -2.56446
NSD2 nuclear receptor binding SET domain protein 2 -2.56007
ASF1B anti-silencing function 1B histone chaperone -2.54744
RFC3 replication factor C (activator 1) 3, 38kDa -2.51069
DCK deoxycytidine kinase -2.49039
CDT1 chromatin licensing and DNA replication factor 1 -2.46978
TUBG1 tubulin, gamma 1 -2.45878
TEX30 testis expressed 30 -2.45318
CDKN3 cyclin-dependent kinase inhibitor 3 -2.44896
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -2.43933
NEK2 NIMA-related kinase 2 -2.43391
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.42242
PTTG1 pituitary tumor-transforming 1 -2.41812
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.41244
TRIP13 thyroid hormone receptor interactor 13 -2.40848
KIF15 kinesin family member 15 -2.39199
CEP55 centrosomal protein 55kDa -2.35671
GAR1 GAR1 ribonucleoprotein -2.3437
PARP2 poly (ADP-ribose) polymerase 2 -2.32707
FOXM1 forkhead box M1 -2.32459
NUP85 nucleoporin 85kDa -2.31067
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.30656
NUSAP1 nucleolar and spindle associated protein 1 -2.30111
DNA2 DNA replication helicase/nuclease 2 -2.29597
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.28606
VRK1 vaccinia related kinase 1 -2.26678
FEN1 flap structure-specific endonuclease 1 -2.266
RACGAP1 Rac GTPase activating protein 1 -2.26491
BORA bora, aurora kinase A activator -2.26479
OIP5 Opa interacting protein 5 -2.25224
NDC80 NDC80 kinetochore complex component -2.24743
TTK TTK protein kinase -2.24526
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.22721
PRC1 protein regulator of cytokinesis 1 -2.22113
SPC25 SPC25, NDC80 kinetochore complex component -2.21373
CENPN centromere protein N -2.2133
MCM5 minichromosome maintenance complex component 5 -2.20966
CKS2 CDC28 protein kinase regulatory subunit 2 -2.20555
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa -2.20012
TPX2 TPX2, microtubule-associated -2.18634
TK1 thymidine kinase 1, soluble -2.17354
UBE2S ubiquitin-conjugating enzyme E2S -2.15864
PHGDH phosphoglycerate dehydrogenase -2.15571
CDCA3 cell division cycle associated 3 -2.14583
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.13849
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.12896
MCM4 minichromosome maintenance complex component 4 -2.12733
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.11681
SPDL1 spindle apparatus coiled-coil protein 1 -2.11272
RBBP8 retinoblastoma binding protein 8 -2.1067
KIF20A kinesin family member 20A -2.09215
RPA3 replication protein A3, 14kDa -2.08717
EXOSC9 exosome component 9 -2.081
DEPDC1 DEP domain containing 1 -2.07962
MCMBP minichromosome maintenance complex binding protein -2.0786
LMNB1 lamin B1 -2.07481
NUP93 nucleoporin 93kDa -2.07415
UNG uracil-DNA glycosylase -2.05956
H2AX H2A.X variant histone -2.05208
NCAPH non-SMC condensin I complex, subunit H -2.03769
TACC3 transforming, acidic coiled-coil containing protein 3 -2.03647
CKAP2 cytoskeleton associated protein 2 -2.02841
CDC25B cell division cycle 25B -2.02689
BANF1 barrier to autointegration factor 1 -2.02621
EMC8 ER membrane protein complex subunit 8 -2.0216
ECT2 epithelial cell transforming 2 -2.00572