CRCGN015_MCF10A_48H:N22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenylephrine 101.79 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN015_MCF10A_48H:N22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 4.81172
CHMP6 charged multivesicular body protein 6 4.73289
KIFBP kinesin family binding protein 3.91071
EPN2 epsin 2 3.07734
RRAGA Ras-related GTP binding A 2.98841
IGHMBP2 immunoglobulin mu binding protein 2 2.85461
USP6NL USP6 N-terminal like 2.67519
HACD3 3-hydroxyacyl-CoA dehydratase 3 2.51868
LHX5 LIM homeobox 5 2.48503
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.42012
CLDN9 claudin 9 2.33615
PDLIM1 PDZ and LIM domain 1 2.32353
ALX4 ALX homeobox 4 2.28563
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2.27758
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.2529
PTCH2 patched 2 2.24576
NEUROD2 neuronal differentiation 2 2.23795
PRDM16 PR domain containing 16 2.22684
SAMD4B sterile alpha motif domain containing 4B 2.21018
ADGRL3 adhesion G protein-coupled receptor L3 2.20841
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.20482
CAPN10 calpain 10 2.18047
SHH sonic hedgehog 2.17003
LCN1 lipocalin 1 2.15551
PPCDC phosphopantothenoylcysteine decarboxylase 2.14969
PRDM8 PR domain containing 8 2.12403
LHX1 LIM homeobox 1 2.12291
ADM2 adrenomedullin 2 2.1203
SSTR5 somatostatin receptor 5 2.10371
WNT3 wingless-type MMTV integration site family, member 3 2.07408
GPR20 G protein-coupled receptor 20 2.07385
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.07123
CBX2 chromobox homolog 2 2.06855
INSL6 insulin-like 6 2.06339
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 2.04878
TMEM223 transmembrane protein 223 2.04265
LRRC14 leucine rich repeat containing 14 2.02865
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 2.0272
AIRE autoimmune regulator 2.02565
MYH13 myosin, heavy chain 13, skeletal muscle 2.01018
TLE6 transducin-like enhancer of split 6 2.00883
FHIT fragile histidine triad 2.00297

decreased expression

Symbol Name Standardized Value
DERA deoxyribose-phosphate aldolase (putative) -5.30616
CCNH cyclin H -5.19717
YME1L1 YME1-like 1 ATPase -4.85739
MAPK13 mitogen-activated protein kinase 13 -3.60045
LOC124907782 dual specificity protein phosphatase 22 -3.10835
SRFBP1 serum response factor binding protein 1 -3.02086
S100A8 S100 calcium binding protein A8 -2.93903
ABI1 abl-interactor 1 -2.52404
ISOC1 isochorismatase domain containing 1 -2.31712
LDHB lactate dehydrogenase B -2.2961
ADGRA3 adhesion G protein-coupled receptor A3 -2.18697
LOC112694756 uncharaterized LOC112694756 -2.10058
BCL7B B-cell CLL/lymphoma 7B -2.09128
PLEKHA5 pleckstrin homology domain containing, family A member 5 -2.08219
PGLS 6-phosphogluconolactonase -2.04108
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) -2.03788