CRCGN015_MCF10A_48H:O01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN015_MCF10A_48H:O01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUCB2 nucleobindin 2 7.47464
GET1 guided entry of tail-anchored proteins factor 1 4.16598
S100A4 S100 calcium binding protein A4 3.86713
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.80867
ELAC2 elaC ribonuclease Z 2 2.78388
PYCR1 pyrroline-5-carboxylate reductase 1 2.59167
RUVBL2 RuvB-like AAA ATPase 2 2.21867
HBA1 hemoglobin, alpha 1 2.18513
RLIG1 RNA 5'-phosphate and 3'-OH ligase 1 2.17634
MRPS22 mitochondrial ribosomal protein S22 2.14881
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.099
USP6NL USP6 N-terminal like 2.07106
MYOD1 myogenic differentiation 1 2.05425
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 2.04557
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.0455
TMCO1 transmembrane and coiled-coil domains 1 2.0151
GYG1 glycogenin 1 2.00601

decreased expression

Symbol Name Standardized Value
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.54214
CIAPIN1 cytokine induced apoptosis inhibitor 1 -4.49112
FOXJ3 forkhead box J3 -3.47411
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -3.24934
OAT ornithine aminotransferase -2.86358
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like -2.31418
NLRP2 NLR family, pyrin domain containing 2 -2.2775
LDHB lactate dehydrogenase B -2.25745
COL13A1 collagen, type XIII, alpha 1 -2.23132
TRIM49D2 tripartite motif containing 49D2 -2.18849
LRRC19 leucine rich repeat containing 19 -2.16502
MKNK1 MAP kinase interacting serine/threonine kinase 1 -2.13438
PRAME preferentially expressed antigen in melanoma -2.12836
HAAO 3-hydroxyanthranilate 3,4-dioxygenase -2.11754
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 -2.11536
CHAMP1 chromosome alignment maintaining phosphoprotein 1 -2.10471
STARD3 StAR-related lipid transfer (START) domain containing 3 -2.10109
H2AB2 H2A.B variant histone 2 -2.09163
HMG20B high mobility group 20B -2.08642
LGSN lengsin, lens protein with glutamine synthetase domain -2.06306
CHIT1 chitinase 1 (chitotriosidase) -2.02516
LAMP3 lysosomal-associated membrane protein 3 -2.0216
PRDM13 PR domain containing 13 -2.01577
SMG9 SMG9 nonsense mediated mRNA decay factor -2.00481