CRCGN015_MCF10A_48H:O03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN015_MCF10A_48H:O03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WIF1 WNT inhibitory factor 1 5.39694
PRKCQ protein kinase C, theta 3.58493
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.29003
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.11739
CCP110 centriolar coiled coil protein 110kDa 2.93982
KRT20 keratin 20, type I 2.46503
ANO10 anoctamin 10 2.41839
GPA33 glycoprotein A33 (transmembrane) 2.39528
KATNA1 katanin p60 (ATPase containing) subunit A 1 2.36519
MOK MOK protein kinase 2.25284
FABP1 fatty acid binding protein 1, liver 2.24762
CDX2 caudal type homeobox 2 2.16477
NPY5R neuropeptide Y receptor Y5 2.15512
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 2.11952
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 2.10393
RPS19 ribosomal protein S19 2.06558
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 2.04569
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.03522
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 2.02416
CHP2 calcineurin-like EF-hand protein 2 2.01631
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.01425
SLC26A3 solute carrier family 26 (anion exchanger), member 3 2.00948

decreased expression

Symbol Name Standardized Value
SNX7 sorting nexin 7 -5.60014
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.81773
HSPA1A heat shock 70kDa protein 1A -3.1996
KRT14 keratin 14, type I -3.122
KRT7 keratin 7, type II -3.01019
OXA1L oxidase (cytochrome c) assembly 1-like -2.86228
TM9SF3 transmembrane 9 superfamily member 3 -2.83381
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.60259
IGFBP7 insulin-like growth factor binding protein 7 -2.59323
PDLIM1 PDZ and LIM domain 1 -2.54299
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -2.44987
KLHDC2 kelch domain containing 2 -2.18997
ATG4A autophagy related 4A, cysteine peptidase -2.15455
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.13377
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -2.09482
SERTAD2 SERTA domain containing 2 -2.04586
ARAF A-Raf proto-oncogene, serine/threonine kinase -2.0203
IER2 immediate early response 2 -2.01925