CRCGN015_MCF10A_48H:O06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN015_MCF10A_48H:O06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 5.08229
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.82533
AXIN1 axin 1 4.57197
SMIM40 small integral membrane protein 40 4.1631
GRWD1 glutamate-rich WD repeat containing 1 4.05647
WIF1 WNT inhibitory factor 1 3.46551
FPGS folylpolyglutamate synthase 3.19765
MAPK9 mitogen-activated protein kinase 9 2.45324
ZNF384 zinc finger protein 384 2.44249
ZNF761 zinc finger protein 761 2.27526
SNRPC small nuclear ribonucleoprotein polypeptide C 2.2585
SAP30L SAP30-like 2.19873
TOMM34 translocase of outer mitochondrial membrane 34 2.1814
PUS3 pseudouridylate synthase 3 2.16987
CCDC85B coiled-coil domain containing 85B 2.15102
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.12523
NFRKB nuclear factor related to kappaB binding protein 2.06951
TCOF1 Treacher Collins-Franceschetti syndrome 1 2.06934
MEX3C mex-3 RNA binding family member C 2.06256
ZNF7 zinc finger protein 7 2.04226
TRAPPC4 trafficking protein particle complex 4 2.03617
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 2.00994
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.00982

decreased expression

Symbol Name Standardized Value
GRN granulin -5.28058
YME1L1 YME1-like 1 ATPase -4.58427
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.34488
KRT7 keratin 7, type II -3.69696
SYNPO2L synaptopodin 2-like -2.73312
CDK5RAP3 CDK5 regulatory subunit associated protein 3 -2.6551
VIM vimentin -2.59983
FOXJ3 forkhead box J3 -2.56937
CYBA cytochrome b-245, alpha polypeptide -2.48936
CUL2 cullin 2 -2.48113
NAGK N-acetylglucosamine kinase -2.39926
PDLIM1 PDZ and LIM domain 1 -2.38965
FOXE1 forkhead box E1 -2.28299
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -2.28005
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -2.2575
ANKRD10 ankyrin repeat domain 10 -2.20787
TEX14 testis expressed 14 -2.17167
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -2.15253
PGAM2 phosphoglycerate mutase 2 (muscle) -2.12813
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -2.0962
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) -2.04379
KLHL41 kelch-like family member 41 -2.03135
HRC histidine rich calcium binding protein -2.02329
VASH2 vasohibin 2 -2.01689