CRCGN015_MCF10A_48H:O07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description indometacin 99.61 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

148 genes differentially expressed following the CRCGN015_MCF10A_48H:O07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PRR7 proline rich 7 (synaptic) 4.21119
SMIM40 small integral membrane protein 40 3.75183
ANO10 anoctamin 10 3.74568
UBQLN2 ubiquilin 2 3.60345
KDM5A lysine (K)-specific demethylase 5A 3.3202
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.25701
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.20698
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.11252
ABHD4 abhydrolase domain containing 4 3.0897
GPER1 G protein-coupled estrogen receptor 1 2.88376
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.71915
LMTK1 lemur tail kinase 1 2.63731
HMGA2 high mobility group AT-hook 2 2.57143
SQSTM1 sequestosome 1 2.45729
PPP4R1 protein phosphatase 4, regulatory subunit 1 2.42642
RRAGC Ras-related GTP binding C 2.39883
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.38524
INTS6 integrator complex subunit 6 2.35186
MNT MAX network transcriptional repressor 2.34637
CDPF1 cysteine-rich, DPF motif domain containing 1 2.33191
STX1A syntaxin 1A (brain) 2.32176
CALML5 calmodulin-like 5 2.31898
GARS1 glycyl-tRNA synthetase 1 2.31828
MACF1 microtubule-actin crosslinking factor 1 2.30546
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.30348
DUSP4 dual specificity phosphatase 4 2.27014
METRN meteorin, glial cell differentiation regulator 2.26549
FHL2 four and a half LIM domains 2 2.24947
ADGRG6 adhesion G protein-coupled receptor G6 2.19958
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.16839
IFT88 intraflagellar transport 88 2.16202
MEX3C mex-3 RNA binding family member C 2.15121
SPATA2L spermatogenesis associated 2-like 2.14175
CARS1 cysteinyl-tRNA synthetase 1 2.13279
STBD1 starch binding domain 1 2.13156
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.12621
EPB41L4B erythrocyte membrane protein band 4.1 like 4B 2.12588
EFNA3 ephrin-A3 2.12575
CASZ1 castor zinc finger 1 2.11836
PYGB phosphorylase, glycogen; brain 2.09924
EFL1 elongation factor like GTPase 1 2.08277
COL17A1 collagen, type XVII, alpha 1 2.0765
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.07353
GNG5 guanine nucleotide binding protein (G protein), gamma 5 2.06971
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.06562
DUSP8 dual specificity phosphatase 8 2.05507
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 2.05072
KLHL21 kelch-like family member 21 2.04806
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.0241
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.01358
TBCB tubulin folding cofactor B 2.0133
PRELID3A PRELI domain containing 3A 2.00236
F12 coagulation factor XII (Hageman factor) 2.00151

decreased expression

Symbol Name Standardized Value
S100A8 S100 calcium binding protein A8 -4.5275
PPIC peptidylprolyl isomerase C (cyclophilin C) -3.55575
PCNA proliferating cell nuclear antigen -3.544
TCTA T-cell leukemia translocation altered -3.45039
CDK1 cyclin-dependent kinase 1 -3.32506
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -3.20825
CCNB2 cyclin B2 -3.13723
CCNA2 cyclin A2 -3.09914
NCAPD3 non-SMC condensin II complex, subunit D3 -3.06285
KIF11 kinesin family member 11 -2.96219
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.95574
CDC20 cell division cycle 20 -2.90053
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.89359
COG7 component of oligomeric golgi complex 7 -2.86884
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.86292
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.85333
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.85296
GOLT1B golgi transport 1B -2.8498
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.82901
RECQL RecQ helicase-like -2.73547
LDHB lactate dehydrogenase B -2.73043
KIF18B kinesin family member 18B -2.72875
MELK maternal embryonic leucine zipper kinase -2.6996
PLS1 plastin 1 -2.69893
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.69295
PXMP4 peroxisomal membrane protein 4, 24kDa -2.62328
KIF14 kinesin family member 14 -2.61467
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.58317
BCCIP BRCA2 and CDKN1A interacting protein -2.52675
DCK deoxycytidine kinase -2.49422
CCNB1 cyclin B1 -2.49063
STMN1 stathmin 1 -2.49013
SMNDC1 survival motor neuron domain containing 1 -2.48214
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -2.45357
EXO1 exonuclease 1 -2.44613
GPN3 GPN-loop GTPase 3 -2.44503
CYCS cytochrome c, somatic -2.44286
ASF1B anti-silencing function 1B histone chaperone -2.44267
TTK TTK protein kinase -2.43663
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein -2.4349
RRM2 ribonucleotide reductase M2 -2.42606
ZWINT ZW10 interacting kinetochore protein -2.41188
NUP37 nucleoporin 37kDa -2.39445
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.37452
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa -2.35831
HEATR1 HEAT repeat containing 1 -2.35201
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -2.35187
VIM vimentin -2.34572
UBE2C ubiquitin-conjugating enzyme E2C -2.34501
KIF4A kinesin family member 4A -2.33768
NUSAP1 nucleolar and spindle associated protein 1 -2.33061
DEPDC1 DEP domain containing 1 -2.32283
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -2.32069
TOP2A topoisomerase (DNA) II alpha 170kDa -2.31299
KNTC1 kinetochore associated 1 -2.30978
GRAMD2B GRAM domain containing 2B -2.29733
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.28953
NEK2 NIMA-related kinase 2 -2.2698
ZNF692 zinc finger protein 692 -2.25325
GEMIN2 gem (nuclear organelle) associated protein 2 -2.23518
BIRC5 baculoviral IAP repeat containing 5 -2.23147
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.22923
CKS1B CDC28 protein kinase regulatory subunit 1B -2.20144
H2AX H2A.X variant histone -2.18484
RPA3 replication protein A3, 14kDa -2.1587
TROAP trophinin associated protein -2.15327
CHAF1A chromatin assembly factor 1, subunit A (p150) -2.15146
BLMH bleomycin hydrolase -2.15142
SMIM41 small integral membrane protein 41 -2.14723
NCAPG2 non-SMC condensin II complex, subunit G2 -2.13954
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.13907
NDP Norrie disease (pseudoglioma) -2.13175
UQCRH ubiquinol-cytochrome c reductase hinge protein -2.1307
ORC6 origin recognition complex, subunit 6 -2.12549
HSPB2 heat shock 27kDa protein 2 -2.11899
TRIP13 thyroid hormone receptor interactor 13 -2.08625
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 -2.08166
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.07825
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.07202
FEN1 flap structure-specific endonuclease 1 -2.0688
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.06627
DACT1 dishevelled-binding antagonist of beta-catenin 1 -2.0584
KIF15 kinesin family member 15 -2.05463
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 -2.03874
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.03122
MCM6 minichromosome maintenance complex component 6 -2.02835
VDAC3 voltage-dependent anion channel 3 -2.02778
RFC3 replication factor C (activator 1) 3, 38kDa -2.02637
NID2 nidogen 2 (osteonidogen) -2.02548
KIF20B kinesin family member 20B -2.02336
CISD1 CDGSH iron sulfur domain 1 -2.02249
DPY19L1 dpy-19-like 1 (C. elegans) -2.0219
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) -2.01053
CENPU centromere protein U -2.00797
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.00432