CRCGN015_MCF10A_48H:O12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description amsacrine 10.79 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

666 genes differentially expressed following the CRCGN015_MCF10A_48H:O12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 6.68798
FHL2 four and a half LIM domains 2 5.27729
SQSTM1 sequestosome 1 5.23542
HSPA1A heat shock 70kDa protein 1A 4.60427
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.29144
STAP2 signal transducing adaptor family member 2 4.19754
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.17163
WIF1 WNT inhibitory factor 1 3.76138
OSBPL2 oxysterol binding protein-like 2 3.49755
CALCOCO1 calcium binding and coiled-coil domain 1 3.46599
TRAFD1 TRAF-type zinc finger domain containing 1 3.45426
SNX11 sorting nexin 11 3.4297
GRN granulin 3.38922
WASHC5 WASH complex subunit 5 3.3891
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 3.37146
TERF2IP telomeric repeat binding factor 2, interacting protein 3.35465
TUFT1 tuftelin 1 3.32629
OPTN optineurin 3.3163
VAT1 vesicle amine transport 1 3.25748
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 3.23172
GOLGB1 golgin B1 3.22118
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) 3.14692
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 3.10708
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.02923
NGRN neugrin, neurite outgrowth associated 3.02237
LIN37 lin-37 DREAM MuvB core complex component 3.02232
CRELD1 cysteine-rich with EGF-like domains 1 2.99244
GCC1 GRIP and coiled-coil domain containing 1 2.98893
H2BC21 H2B clustered histone 21 2.98329
GPR137B G protein-coupled receptor 137B 2.96831
GDI1 GDP dissociation inhibitor 1 2.91877
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 2.90838
TOMM34 translocase of outer mitochondrial membrane 34 2.90476
GABARAP GABA(A) receptor-associated protein 2.90444
SSBP2 single-stranded DNA binding protein 2 2.87383
EIF4A2 eukaryotic translation initiation factor 4A2 2.86305
TSG101 tumor susceptibility 101 2.85794
UBQLN2 ubiquilin 2 2.84876
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.84385
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.83267
GPKOW G patch domain and KOW motifs 2.82683
ATF3 activating transcription factor 3 2.80365
IP6K2 inositol hexakisphosphate kinase 2 2.80234
ATF4 activating transcription factor 4 2.7964
DLK1 delta-like 1 homolog (Drosophila) 2.79381
MVP major vault protein 2.77388
IST1 increased sodium tolerance 1 homolog (yeast) 2.76392
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 2.7542
LRRC32 leucine rich repeat containing 32 2.74324
FDXR ferredoxin reductase 2.73846
CYB5R1 cytochrome b5 reductase 1 2.73649
SMG5 SMG5 nonsense mediated mRNA decay factor 2.69745
ABHD4 abhydrolase domain containing 4 2.69741
PHF21A PHD finger protein 21A 2.66794
LPIN2 lipin 2 2.66582
BHLHE41 basic helix-loop-helix family, member e41 2.66539
DDB2 damage-specific DNA binding protein 2, 48kDa 2.66049
RRAGC Ras-related GTP binding C 2.65163
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 2.64323
SARAF store-operated calcium entry-associated regulatory factor 2.63781
EPHA2 EPH receptor A2 2.63525
SPG11 spastic paraplegia 11 (autosomal recessive) 2.63351
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2.63283
IFRD1 interferon-related developmental regulator 1 2.62909
TMUB2 transmembrane and ubiquitin-like domain containing 2 2.6105
CSRNP2 cysteine-serine-rich nuclear protein 2 2.60924
ATG2A autophagy related 2A 2.59848
TFE3 transcription factor binding to IGHM enhancer 3 2.59812
WBP2 WW domain binding protein 2 2.59062
TTC4 tetratricopeptide repeat domain 4 2.58196
HAGH hydroxyacylglutathione hydrolase 2.57848
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 2.57656
LHFPL2 lipoma HMGIC fusion partner-like 2 2.57219
QSOX1 quiescin Q6 sulfhydryl oxidase 1 2.54897
ENAH enabled homolog (Drosophila) 2.53891
JMJD6 jumonji domain containing 6 2.52283
KDM6B lysine (K)-specific demethylase 6B 2.52121
WBP1L WW domain binding protein 1-like 2.51975
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 2.51958
LSP1 lymphocyte-specific protein 1 2.50754
IFI35 interferon-induced protein 35 2.50746
AEN apoptosis enhancing nuclease 2.50574
WHRN whirlin 2.5029
INSIG2 insulin induced gene 2 2.50086
YPEL5 yippee-like 5 (Drosophila) 2.48144
NECAP1 NECAP endocytosis associated 1 2.47944
BAHD1 bromo adjacent homology domain containing 1 2.47935
ATG101 autophagy related 101 2.46948
NAGK N-acetylglucosamine kinase 2.46059
QPCT glutaminyl-peptide cyclotransferase 2.45992
GPX2 glutathione peroxidase 2 2.44115
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 2.43459
STXBP2 syntaxin binding protein 2 2.43388
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 2.42466
CCNDBP1 cyclin D-type binding-protein 1 2.42265
RNF111 ring finger protein 111 2.42057
LRP10 low density lipoprotein receptor-related protein 10 2.4199
GOLPH3L golgi phosphoprotein 3-like 2.41465
HSPA1B heat shock 70kDa protein 1B 2.41424
KIF3C kinesin family member 3C 2.4029
HEATR6 HEAT repeat containing 6 2.3898
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 2.37706
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 2.36958
MAD2L1BP MAD2L1 binding protein 2.36854
CXCL2 chemokine (C-X-C motif) ligand 2 2.36765
SLC67A1 solute carrier family 67 member 1 2.3676
PLPP2 phospholipid phosphatase 2 2.36559
RNF25 ring finger protein 25 2.36524
RNPS1 RNA binding protein S1, serine-rich domain 2.36508
AP3S2 adaptor-related protein complex 3, sigma 2 subunit 2.36482
FGL1 fibrinogen-like 1 2.36382
IFI27 interferon, alpha-inducible protein 27 2.36371
FEM1C fem-1 homolog c (C. elegans) 2.36305
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 2.35542
RHBDF1 rhomboid 5 homolog 1 (Drosophila) 2.34912
TUBB2B tubulin, beta 2B class IIb 2.3444
NIT1 nitrilase 1 2.34264
IRF9 interferon regulatory factor 9 2.33962
PRSS3 protease, serine, 3 2.33954
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 2.331
EMC7 ER membrane protein complex subunit 7 2.32535
RAB4B RAB4B, member RAS oncogene family 2.32532
FTSJ3 FtsJ homolog 3 (E. coli) 2.32414
GDF15 growth differentiation factor 15 2.32225
LIMS2 LIM and senescent cell antigen-like domains 2 2.31885
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.3057
STK10 serine/threonine kinase 10 2.30179
MADD MAP-kinase activating death domain 2.29915
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.29063
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.29043
TRIB1 tribbles pseudokinase 1 2.28273
ZCCHC2 zinc finger, CCHC domain containing 2 2.28114
ACVR2A activin A receptor, type IIA 2.27984
PRAF2 PRA1 domain family, member 2 2.27652
SAP30BP SAP30 binding protein 2.27587
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.27566
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2.27427
RIGI RNA sensor RIG-I 2.27279
POF1B premature ovarian failure, 1B 2.26679
PPME1 protein phosphatase methylesterase 1 2.26618
PLK3 polo-like kinase 3 2.26525
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 2.26232
RNF10 ring finger protein 10 2.25185
HDLBP high density lipoprotein binding protein 2.25007
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 2.24767
DVL3 dishevelled segment polarity protein 3 2.24534
AP1M2 adaptor-related protein complex 1, mu 2 subunit 2.24322
NEIL1 nei endonuclease VIII-like 1 (E. coli) 2.23989
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 2.2365
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2.22563
PGPEP1 pyroglutamyl-peptidase I 2.22319
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2.22008
APOL1 apolipoprotein L, 1 2.21958
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 2.21112
NPPB natriuretic peptide B 2.20942
EFL1 elongation factor like GTPase 1 2.20724
SNCG synuclein, gamma (breast cancer-specific protein 1) 2.20645
IDS iduronate 2-sulfatase 2.20535
ISG20 interferon stimulated exonuclease gene 20kDa 2.20476
ATXN2 ataxin 2 2.20267
LUC7L LUC7-like (S. cerevisiae) 2.20095
STAT5A signal transducer and activator of transcription 5A 2.20091
NUP58 nucleoporin 58 2.19871
CCPG1 cell cycle progression 1 2.19248
FAM174B family with sequence similarity 174, member B 2.18971
PRKCD protein kinase C, delta 2.18912
MTCH1 mitochondrial carrier 1 2.18526
STBD1 starch binding domain 1 2.17771
NAT9 N-acetyltransferase 9 (GCN5-related, putative) 2.17534
IRF7 interferon regulatory factor 7 2.16805
BLCAP bladder cancer associated protein 2.16609
SFRP5 secreted frizzled-related protein 5 2.16575
JUN jun proto-oncogene 2.16362
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 2.16022
IQCB1 IQ motif containing B1 2.16003
SPAG7 sperm associated antigen 7 2.15824
DIABLO diablo, IAP-binding mitochondrial protein 2.15816
TTC17 tetratricopeptide repeat domain 17 2.15738
FBRS fibrosin 2.15607
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.15295
FICD FIC domain containing 2.15222
EBI3 Epstein-Barr virus induced 3 2.15211
PLA2G15 phospholipase A2, group XV 2.14441
PEF1 penta-EF-hand domain containing 1 2.14378
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.14342
SHARPIN SHANK-associated RH domain interactor 2.14309
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) 2.13624
MFGE8 milk fat globule-EGF factor 8 protein 2.13554
GDAP2 ganglioside induced differentiation associated protein 2 2.13146
METTL25B methyltransferase like 25B 2.12966
STK25 serine/threonine kinase 25 2.12746
CPT1B carnitine palmitoyltransferase 1B (muscle) 2.12737
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 2.12152
TSLIG3A tRNA splicing ligase complex subunit 3A 2.1194
TMEM53 transmembrane protein 53 2.11767
PRSS8 protease, serine, 8 2.11741
SSPN sarcospan 2.11471
CD9 CD9 molecule 2.11328
SPATA20 spermatogenesis associated 20 2.113
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 2.11216
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 2.11039
BANP BTG3 associated nuclear protein 2.10811
CBX4 chromobox homolog 4 2.10381
STX5 syntaxin 5 2.10246
DSG2 desmoglein 2 2.09891
CAB39L calcium binding protein 39-like 2.09671
CTSA cathepsin A 2.09525
TLN1 talin 1 2.09428
UBA7 ubiquitin-like modifier activating enzyme 7 2.08505
NAPSA napsin A aspartic peptidase 2.08383
MED8 mediator complex subunit 8 2.08382
FAM50A family with sequence similarity 50, member A 2.08339
SARS1 seryl-tRNA synthetase 1 2.08185
PRDM4 PR domain containing 4 2.08172
TMEM45A transmembrane protein 45A 2.08103
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.07755
CARS1 cysteinyl-tRNA synthetase 1 2.07704
DUSP4 dual specificity phosphatase 4 2.06903
ZNF133 zinc finger protein 133 2.06587
DCAF8 DDB1 and CUL4 associated factor 8 2.06307
H2BC12 H2B clustered histone 12 2.063
FBXL12 F-box and leucine-rich repeat protein 12 2.05907
CRHBP corticotropin releasing hormone binding protein 2.05903
SDC4 syndecan 4 2.05869
HMOX1 heme oxygenase 1 2.05801
C6ORF89 chromosome 6 open reading frame 89 2.05768
BTG2 BTG family, member 2 2.05432
SKIC2 SKI2 subunit of superkiller complex 2.05265
SUCO SUN domain containing ossification factor 2.05191
ITGAV integrin, alpha V 2.04723
ENO3 enolase 3 (beta, muscle) 2.04685
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 2.0452
IRF1 interferon regulatory factor 1 2.04483
CST2 cystatin SA 2.04177
MX1 MX dynamin-like GTPase 1 2.04165
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.04124
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 2.03938
HTN3 histatin 3 2.03664
FXR2 fragile X mental retardation, autosomal homolog 2 2.03645
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.03267
MYD88 myeloid differentiation primary response 88 2.03173
GTPBP2 GTP binding protein 2 2.031
ELMO2 engulfment and cell motility 2 2.0288
IER5 immediate early response 5 2.02394
EIF6 eukaryotic translation initiation factor 6 2.02329
PFDN2 prefoldin subunit 2 2.01938
CDKL3 cyclin-dependent kinase-like 3 2.01917
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 2.01809
SRP54 signal recognition particle 54kDa 2.01221
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.01018
IER3 immediate early response 3 2.00728
PPP1R7 protein phosphatase 1, regulatory subunit 7 2.00496
MUC13 mucin 13, cell surface associated 2.00387
MMP10 matrix metallopeptidase 10 2.00359
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 2.0017
BCORL1 BCL6 corepressor-like 1 2.00058

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -9.73581
CDC20 cell division cycle 20 -9.06348
CDK1 cyclin-dependent kinase 1 -8.90482
KIF14 kinesin family member 14 -8.53549
TOP2A topoisomerase (DNA) II alpha 170kDa -7.33581
CCNB2 cyclin B2 -7.23102
CCNA2 cyclin A2 -7.17158
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -7.16568
S100A8 S100 calcium binding protein A8 -7.13842
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -6.59375
NUSAP1 nucleolar and spindle associated protein 1 -6.35179
MCM6 minichromosome maintenance complex component 6 -6.20987
KIF20A kinesin family member 20A -6.03808
TTK TTK protein kinase -6.01843
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -5.94408
PLK1 polo-like kinase 1 -5.88796
NEK2 NIMA-related kinase 2 -5.81344
DEPDC1 DEP domain containing 1 -5.65087
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -5.5837
ZWINT ZW10 interacting kinetochore protein -5.56403
KIF11 kinesin family member 11 -5.50751
RACGAP1 Rac GTPase activating protein 1 -5.48052
BIRC5 baculoviral IAP repeat containing 5 -5.39739
PBK PDZ binding kinase -5.3793
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -5.35807
CENPU centromere protein U -5.33075
UBE2C ubiquitin-conjugating enzyme E2C -5.25563
ASF1B anti-silencing function 1B histone chaperone -5.25122
EXO1 exonuclease 1 -5.24925
SPC25 SPC25, NDC80 kinetochore complex component -5.19117
NCAPG2 non-SMC condensin II complex, subunit G2 -5.16496
MCM10 minichromosome maintenance complex component 10 -5.15625
PRC1 protein regulator of cytokinesis 1 -5.13859
HMMR hyaluronan-mediated motility receptor (RHAMM) -5.13023
CDKN3 cyclin-dependent kinase inhibitor 3 -5.10853
TPX2 TPX2, microtubule-associated -5.0631
RRM2 ribonucleotide reductase M2 -5.04062
CENPA centromere protein A -4.91043
HJURP Holliday junction recognition protein -4.88027
GINS2 GINS complex subunit 2 (Psf2 homolog) -4.87815
FOXM1 forkhead box M1 -4.82627
MKI67 marker of proliferation Ki-67 -4.79873
KIF4A kinesin family member 4A -4.78839
CDCA3 cell division cycle associated 3 -4.75425
CCNB1 cyclin B1 -4.66545
MCM5 minichromosome maintenance complex component 5 -4.64587
NCAPH non-SMC condensin I complex, subunit H -4.6443
HMGB2 high mobility group box 2 -4.62039
KIF23 kinesin family member 23 -4.60997
STMN1 stathmin 1 -4.60661
KIF18A kinesin family member 18A -4.57966
OIP5 Opa interacting protein 5 -4.56593
CDC6 cell division cycle 6 -4.55521
DCK deoxycytidine kinase -4.55082
LMNB1 lamin B1 -4.53934
ATAD2 ATPase family, AAA domain containing 2 -4.52789
SMC4 structural maintenance of chromosomes 4 -4.44966
CDC45 cell division cycle 45 -4.44524
ERCC6L excision repair cross-complementation group 6-like -4.44441
FEN1 flap structure-specific endonuclease 1 -4.41632
CEP55 centrosomal protein 55kDa -4.41169
CENPN centromere protein N -4.39344
CENPM centromere protein M -4.36101
VRK1 vaccinia related kinase 1 -4.35778
SLC35F2 solute carrier family 35, member F2 -4.33924
PCLAF PCNA clamp associated factor -4.33816
NEIL3 nei endonuclease VIII-like 3 (E. coli) -4.3248
TRIP13 thyroid hormone receptor interactor 13 -4.31858
RFC3 replication factor C (activator 1) 3, 38kDa -4.28055
KIF15 kinesin family member 15 -4.22951
CHEK1 checkpoint kinase 1 -4.21468
MYC v-myc avian myelocytomatosis viral oncogene homolog -4.20756
SHCBP1 SHC SH2-domain binding protein 1 -4.13837
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -4.13594
SPAG5 sperm associated antigen 5 -4.13542
NDC80 NDC80 kinetochore complex component -4.1097
GTSE1 G-2 and S-phase expressed 1 -4.09308
TMPO thymopoietin -4.07351
FBXO5 F-box protein 5 -4.03885
PIMREG PICALM interacting mitotic regulator -4.02043
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -4.0196
CDCA8 cell division cycle associated 8 -3.98959
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.97688
TROAP trophinin associated protein -3.95913
GINS1 GINS complex subunit 1 (Psf1 homolog) -3.93322
PTTG1 pituitary tumor-transforming 1 -3.92653
DHFR dihydrofolate reductase -3.91938
GPHN gephyrin -3.89518
MCM7 minichromosome maintenance complex component 7 -3.86639
NDC1 NDC1 transmembrane nucleoporin -3.83487
CKS2 CDC28 protein kinase regulatory subunit 2 -3.8138
UBE2S ubiquitin-conjugating enzyme E2S -3.81016
FIRRM FIGNL1 interacting regulator of recombination and mitosis -3.76666
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.75571
ECT2 epithelial cell transforming 2 -3.71969
KIFC1 kinesin family member C1 -3.70967
MCM4 minichromosome maintenance complex component 4 -3.70728
CKS1B CDC28 protein kinase regulatory subunit 1B -3.69001
RPA3 replication protein A3, 14kDa -3.68387
FANCI Fanconi anemia, complementation group I -3.68064
CDC25C cell division cycle 25C -3.67911
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.67877
SNRPA small nuclear ribonucleoprotein polypeptide A -3.66552
NCAPG non-SMC condensin I complex, subunit G -3.61436
BRCA1 breast cancer 1, early onset -3.6072
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -3.59308
CDK4 cyclin-dependent kinase 4 -3.57301
CENPF centromere protein F, 350/400kDa -3.55968
CDK2 cyclin-dependent kinase 2 -3.55563
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -3.55458
KIF18B kinesin family member 18B -3.52919
MCM3 minichromosome maintenance complex component 3 -3.50732
RRM1 ribonucleotide reductase M1 -3.46014
GINS4 GINS complex subunit 4 (Sld5 homolog) -3.44318
NUP37 nucleoporin 37kDa -3.43961
CKAP2 cytoskeleton associated protein 2 -3.43591
TK1 thymidine kinase 1, soluble -3.40458
WDR76 WD repeat domain 76 -3.3896
DSN1 DSN1, MIS12 kinetochore complex component -3.38746
SDHAF3 succinate dehydrogenase complex assembly factor 3 -3.37926
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -3.37359
H2AX H2A.X variant histone -3.36874
RMI1 RecQ mediated genome instability 1 -3.35418
DBF4 DBF4 zinc finger -3.34633
PARP1 poly (ADP-ribose) polymerase 1 -3.33333
ZWILCH zwilch kinetochore protein -3.32731
CENPI centromere protein I -3.32298
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant -3.32093
CDT1 chromatin licensing and DNA replication factor 1 -3.31929
ORC6 origin recognition complex, subunit 6 -3.31346
HPRT1 hypoxanthine phosphoribosyltransferase 1 -3.29056
PLK4 polo-like kinase 4 -3.28739
TACC3 transforming, acidic coiled-coil containing protein 3 -3.28722
ZNF551 zinc finger protein 551 -3.25364
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -3.24432
TIPIN TIMELESS interacting protein -3.21428
UNG uracil-DNA glycosylase -3.2065
BARD1 BRCA1 associated RING domain 1 -3.20494
DONSON downstream neighbor of SON -3.20462
SPDL1 spindle apparatus coiled-coil protein 1 -3.1956
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) -3.1899
HSPD1 heat shock 60kDa protein 1 (chaperonin) -3.18948
PARPBP PARP1 binding protein -3.15788
MIS18A MIS18 kinetochore protein A -3.15562
TDP1 tyrosyl-DNA phosphodiesterase 1 -3.15121
CHAF1B chromatin assembly factor 1, subunit B (p60) -3.13436
CYCS cytochrome c, somatic -3.12058
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 -3.11633
GCSH glycine cleavage system protein H (aminomethyl carrier) -3.11065
LBR lamin B receptor -3.11011
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -3.09072
DUT deoxyuridine triphosphatase -3.08021
EMC8 ER membrane protein complex subunit 8 -3.0797
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -3.07456
SLC25A40 solute carrier family 25, member 40 -3.06504
TFDP1 transcription factor Dp-1 -3.04654
NCAPD3 non-SMC condensin II complex, subunit D3 -3.03436
PSRC1 proline/serine-rich coiled-coil 1 -3.02781
UXT ubiquitously-expressed, prefoldin-like chaperone -3.01783
TMX1 thioredoxin-related transmembrane protein 1 -2.99324
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) -2.97483
RAD51AP1 RAD51 associated protein 1 -2.97312
RBBP8 retinoblastoma binding protein 8 -2.96801
ANAPC1 anaphase promoting complex subunit 1 -2.95661
GLRX5 glutaredoxin 5 -2.95474
HMGB1 high mobility group box 1 -2.95165
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -2.94595
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -2.9172
CASP8AP2 caspase 8 associated protein 2 -2.91574
GPSM2 G-protein signaling modulator 2 -2.91074
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 -2.89127
WDR12 WD repeat domain 12 -2.88944
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 -2.87726
NUP205 nucleoporin 205kDa -2.87306
WDHD1 WD repeat and HMG-box DNA binding protein 1 -2.86723
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase -2.85481
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.83501
EXOC5 exocyst complex component 5 -2.83195
RPP40 ribonuclease P/MRP 40kDa subunit -2.83193
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -2.82728
LDHB lactate dehydrogenase B -2.81911
DLAT dihydrolipoamide S-acetyltransferase -2.7886
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) -2.78638
S100A9 S100 calcium binding protein A9 -2.76554
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.75991
HADH hydroxyacyl-CoA dehydrogenase -2.75917
FANCC Fanconi anemia, complementation group C -2.75268
NPM3 nucleophosmin/nucleoplasmin 3 -2.74501
SKA1 spindle and kinetochore associated complex subunit 1 -2.74191
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -2.71652
PAGR1 PAXIP1 associated glutamate-rich protein 1 -2.69468
MCUR1 mitochondrial calcium uniporter regulator 1 -2.69464
GEMIN2 gem (nuclear organelle) associated protein 2 -2.6918
HELLS helicase, lymphoid-specific -2.68872
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.68727
DDIT4 DNA-damage-inducible transcript 4 -2.68623
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 -2.6707
SGPP1 sphingosine-1-phosphate phosphatase 1 -2.66852
NEMP1 nuclear envelope integral membrane protein 1 -2.66493
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.66314
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.65864
RBMX RNA binding motif protein, X-linked -2.65126
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 -2.64855
POLR1F RNA polymerase I subunit F -2.6473
FASTKD1 FAST kinase domains 1 -2.63612
ELOVL6 ELOVL fatty acid elongase 6 -2.63549
CENPS-CORT CENPS-CORT readthrough -2.61838
CBX3 chromobox homolog 3 -2.61571
TMEM267 transmembrane protein 267 -2.60942
FXN frataxin -2.60188
ZNF83 zinc finger protein 83 -2.60173
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.59601
FKBP5 FK506 binding protein 5 -2.59399
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.5863
RAB33B RAB33B, member RAS oncogene family -2.5845
RFC4 replication factor C (activator 1) 4, 37kDa -2.56855
GTPBP8 GTP-binding protein 8 (putative) -2.56735
MANEA mannosidase, endo-alpha -2.56711
RUVBL1 RuvB-like AAA ATPase 1 -2.56472
CDCA4 cell division cycle associated 4 -2.55768
GINS3 GINS complex subunit 3 (Psf3 homolog) -2.5494
CCDC15 coiled-coil domain containing 15 -2.54723
MELK maternal embryonic leucine zipper kinase -2.54592
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -2.54438
ZDHHC6 zinc finger, DHHC-type containing 6 -2.53848
TRMT5 tRNA methyltransferase 5 -2.53015
GABPA GA binding protein transcription factor, alpha subunit 60kDa -2.52867
YEATS4 YEATS domain containing 4 -2.52688
CD320 CD320 molecule -2.51791
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.51366
CISD1 CDGSH iron sulfur domain 1 -2.51086
KMT5A lysine methyltransferase 5A -2.50496
ERH enhancer of rudimentary homolog (Drosophila) -2.50032
FOXRED2 FAD-dependent oxidoreductase domain containing 2 -2.49317
PRPF19 pre-mRNA processing factor 19 -2.48801
DNA2 DNA replication helicase/nuclease 2 -2.48675
CBR3 carbonyl reductase 3 -2.48591
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.48581
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 -2.47714
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.47596
AK8 adenylate kinase 8 -2.47326
BORA bora, aurora kinase A activator -2.47136
BLM Bloom syndrome, RecQ helicase-like -2.46841
NUP54 nucleoporin 54kDa -2.46812
ZSCAN5A zinc finger and SCAN domain containing 5A -2.46178
HMGN2 high mobility group nucleosomal binding domain 2 -2.45931
RXYLT1 ribitol xylosyltransferase 1 -2.456
MRPL42 mitochondrial ribosomal protein L42 -2.4456
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -2.44488
TP53RK TP53 regulating kinase -2.44188
MCMBP minichromosome maintenance complex binding protein -2.4418
HAT1 histone acetyltransferase 1 -2.43983
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.43881
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -2.43779
RFC2 replication factor C (activator 1) 2, 40kDa -2.42723
CCNE2 cyclin E2 -2.42642
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.42202
RCC1 regulator of chromosome condensation 1 -2.41818
HDAC2 histone deacetylase 2 -2.40937
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -2.40557
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -2.4023
IPO5 importin 5 -2.40058
RFC5 replication factor C (activator 1) 5, 36.5kDa -2.39921
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -2.39665
HAUS4 HAUS augmin-like complex, subunit 4 -2.39554
MED28 mediator complex subunit 28 -2.38923
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.38135
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) -2.37612
METTL8 methyltransferase like 8 -2.36447
CD58 CD58 molecule -2.36243
HACD2 3-hydroxyacyl-CoA dehydratase 2 -2.36168
FRAT2 frequently rearranged in advanced T-cell lymphomas 2 -2.35905
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -2.35815
TMEM135 transmembrane protein 135 -2.35515
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -2.35423
TUBA1B tubulin, alpha 1b -2.35344
MAPKAP1 mitogen-activated protein kinase associated protein 1 -2.34971
ODF2 outer dense fiber of sperm tails 2 -2.3476
RPS5 ribosomal protein S5 -2.34722
PRKDC protein kinase, DNA-activated, catalytic polypeptide -2.34633
MRPL15 mitochondrial ribosomal protein L15 -2.32724
HOXA7 homeobox A7 -2.32511
TCTA T-cell leukemia translocation altered -2.3246
ZNF428 zinc finger protein 428 -2.32318
INCENP inner centromere protein antigens 135/155kDa -2.32299
MPHOSPH9 M-phase phosphoprotein 9 -2.3214
GUF1 GUF1 GTPase homolog (S. cerevisiae) -2.31186
IRX4 iroquois homeobox 4 -2.30967
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.3094
YAP1 Yes-associated protein 1 -2.30644
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.30556
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -2.30471
RUVBL2 RuvB-like AAA ATPase 2 -2.30098
POLK polymerase (DNA directed) kappa -2.29575
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) -2.29448
EXOSC8 exosome component 8 -2.29226
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -2.28613
HNRNPF heterogeneous nuclear ribonucleoprotein F -2.28358
TMEM97 transmembrane protein 97 -2.28282
UCK2 uridine-cytidine kinase 2 -2.27842
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 -2.27779
SLC35A5 solute carrier family 35, member A5 -2.27738
NNT nicotinamide nucleotide transhydrogenase -2.26643
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -2.26242
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.26241
PTGES3 prostaglandin E synthase 3 (cytosolic) -2.25923
RBL1 retinoblastoma-like 1 -2.25797
ADISSP adipose secreted signaling protein -2.25444
SIGMAR1 sigma non-opioid intracellular receptor 1 -2.25429
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.24921
DAZAP1 DAZ associated protein 1 -2.2466
TWSG1 twisted gastrulation BMP signaling modulator 1 -2.24655
RFWD3 ring finger and WD repeat domain 3 -2.24529
NUBPL nucleotide binding protein-like -2.24314
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.24207
ANAPC15 anaphase promoting complex subunit 15 -2.24168
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.24121
CBFB core-binding factor, beta subunit -2.23977
ABHD10 abhydrolase domain containing 10 -2.23404
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.23063
SPA17 sperm autoantigenic protein 17 -2.23018
HMGB3 high mobility group box 3 -2.22628
MRS2 MRS2 magnesium transporter -2.22304
CCNC cyclin C -2.21362
SNRPE small nuclear ribonucleoprotein polypeptide E -2.20753
HMGN1 high mobility group nucleosome binding domain 1 -2.2075
KNTC1 kinetochore associated 1 -2.20463
MTFR1 mitochondrial fission regulator 1 -2.2022
ARHGAP11A Rho GTPase activating protein 11A -2.19963
LMAN1 lectin, mannose-binding, 1 -2.19875
TTF1 transcription termination factor, RNA polymerase I -2.19775
FAM216A family with sequence similarity 216, member A -2.19755
GLUL glutamate-ammonia ligase -2.19735
PPA1 pyrophosphatase (inorganic) 1 -2.19358
NMU neuromedin U -2.18663
CREG1 cellular repressor of E1A-stimulated genes 1 -2.18494
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.17955
EXOSC9 exosome component 9 -2.1772
NCLN nicalin -2.17687
AHCTF1 AT hook containing transcription factor 1 -2.17482
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 -2.16941
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.16721
POMK protein-O-mannose kinase -2.16591
TUBGCP3 tubulin, gamma complex associated protein 3 -2.16555
ARMC1 armadillo repeat containing 1 -2.16533
MRPS2 mitochondrial ribosomal protein S2 -2.16389
NSD2 nuclear receptor binding SET domain protein 2 -2.16314
LTF lactotransferrin -2.16243
PPP2R5D protein phosphatase 2, regulatory subunit B', delta -2.16091
MAPK1 mitogen-activated protein kinase 1 -2.15571
PTMA prothymosin, alpha -2.15481
APOO apolipoprotein O -2.15297
GDE1 glycerophosphodiester phosphodiesterase 1 -2.15133
CMC2 C-x(9)-C motif containing 2 -2.15093
TMEM260 transmembrane protein 260 -2.14976
PSIP1 PC4 and SFRS1 interacting protein 1 -2.14847
COASY CoA synthase -2.14536
HOXB9 homeobox B9 -2.14524
DDTL D-dopachrome tautomerase-like -2.13687
DERA deoxyribose-phosphate aldolase (putative) -2.13211
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -2.12843
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 -2.12796
KPNA3 karyopherin alpha 3 (importin alpha 4) -2.12546
UBIAD1 UbiA prenyltransferase domain containing 1 -2.11234
SRSF3 serine/arginine-rich splicing factor 3 -2.11147
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -2.10833
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa -2.10763
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -2.10528
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -2.10367
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta -2.09668
ADRB2 adrenoceptor beta 2, surface -2.09587
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -2.08507
HEATR3 HEAT repeat containing 3 -2.084
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -2.0797
ARL5A ADP-ribosylation factor-like 5A -2.07849
FUS FUS RNA binding protein -2.07831
NUP160 nucleoporin 160kDa -2.07812
SLC25A46 solute carrier family 25, member 46 -2.07515
ATG5 autophagy related 5 -2.07504
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.07316
HIRIP3 HIRA interacting protein 3 -2.0694
USP1 ubiquitin specific peptidase 1 -2.05954
KIF20B kinesin family member 20B -2.05752
EMP2 epithelial membrane protein 2 -2.05476
GSTM5 glutathione S-transferase mu 5 -2.05335
KIAA0586 KIAA0586 -2.05285
MRPL35 mitochondrial ribosomal protein L35 -2.05022
GCFC2 GC-rich sequence DNA-binding factor 2 -2.04997
IPO8 importin 8 -2.04482
OXCT1 3-oxoacid CoA transferase 1 -2.04347
ADI1 acireductone dioxygenase 1 -2.04199
CHEK2 checkpoint kinase 2 -2.04016
CCNF cyclin F -2.03672
DKK1 dickkopf WNT signaling pathway inhibitor 1 -2.03557
DCPS decapping enzyme, scavenger -2.03553
NAE1 NEDD8 activating enzyme E1 subunit 1 -2.03474
OLA1 Obg-like ATPase 1 -2.03289
AHCY adenosylhomocysteinase -2.03061
FASTKD3 FAST kinase domains 3 -2.02488
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A -2.02398
SIVA1 SIVA1, apoptosis-inducing factor -2.01774
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -2.01411
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.01302
NLRP2 NLR family, pyrin domain containing 2 -2.01262
RNFT1-DT RNFT1 divergent transcript -2.01257
SNRPF small nuclear ribonucleoprotein polypeptide F -2.00939
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.00738
IL18 interleukin 18 -2.00367
HDDC2 HD domain containing 2 -2.00046
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 -2.00041