CRCGN015_MCF10A_48H:O16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5-nitroacenaphthene 98.4 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN015_MCF10A_48H:O16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD4 abhydrolase domain containing 4 5.17265
WIF1 WNT inhibitory factor 1 4.2196
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.489
INTS3 integrator complex subunit 3 3.19545
MACF1 microtubule-actin crosslinking factor 1 2.70038
LRP10 low density lipoprotein receptor-related protein 10 2.63635
KIF3B kinesin family member 3B 2.5183
MYH9 myosin, heavy chain 9, non-muscle 2.50655
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.4556
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.45253
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 2.3856
TSC1 tuberous sclerosis 1 2.35005
HSPB1 heat shock 27kDa protein 1 2.28085
HLA-DRA major histocompatibility complex, class II, DR alpha 2.2713
MYO6 myosin VI 2.25878
SYNGAP1 synaptic Ras GTPase activating protein 1 2.24888
MYL9 myosin, light chain 9, regulatory 2.24445
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.21005
CTSA cathepsin A 2.1988
VAT1 vesicle amine transport 1 2.15705
FGF9 fibroblast growth factor 9 2.07345
EBI3 Epstein-Barr virus induced 3 2.0629
CAVIN2 caveolae associated protein 2 2.03165
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.0262
SPRR1B small proline-rich protein 1B 2.024
GRN granulin 2.01078

decreased expression

Symbol Name Standardized Value
NPDC1 neural proliferation, differentiation and control, 1 -4.865
NCK1 NCK adaptor protein 1 -4.60283
RNASE7 ribonuclease, RNase A family, 7 -3.48727
MELK maternal embryonic leucine zipper kinase -3.175
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.8385
RPN1 ribophorin I -2.7962
SPAG7 sperm associated antigen 7 -2.5886
TSEN34 TSEN34 tRNA splicing endonuclease subunit -2.27545
HPRT1 hypoxanthine phosphoribosyltransferase 1 -2.2169
FAF1 Fas (TNFRSF6) associated factor 1 -2.1885
TCEAL4 transcription elongation factor A (SII)-like 4 -2.1837
TEX10 testis expressed 10 -2.1489
NANS N-acetylneuraminic acid synthase -2.14705
CCP110 centriolar coiled coil protein 110kDa -2.13815
SLC35G2 solute carrier family 35, member G2 -2.1118
UBE2C ubiquitin-conjugating enzyme E2C -2.08725
THAP1 THAP domain containing, apoptosis associated protein 1 -2.06035
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -2.04567
PUS7 pseudouridylate synthase 7 (putative) -2.0229