CRCGN015_MCF10A_48H:O20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulfallate 33.57 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

107 genes differentially expressed following the CRCGN015_MCF10A_48H:O20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PDIA5 protein disulfide isomerase family A, member 5 6.42064
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.78999
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.1395
ZW10 zw10 kinetochore protein 3.8266
CHN1 chimerin 1 3.18755
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 3.02897
OR1F1 olfactory receptor, family 1, subfamily F, member 1 3.00748
PEX11A peroxisomal biogenesis factor 11 alpha 2.89674
TRAM2 translocation associated membrane protein 2 2.7819
TMCC2 transmembrane and coiled-coil domain family 2 2.77846
UBASH3A ubiquitin associated and SH3 domain containing A 2.76093
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.75665
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.70632
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 2.69764
KRTAP5-2 keratin associated protein 5-2 2.69609
PECR peroxisomal trans-2-enoyl-CoA reductase 2.69016
GSTM2 glutathione S-transferase mu 2 (muscle) 2.61094
DLK2 delta-like 2 homolog (Drosophila) 2.59324
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 2.57736
INKA2 inka box actin regulator 2 2.57059
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2.48818
LMO4 LIM domain only 4 2.48389
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 2.46086
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.43584
VSTM4 V-set and transmembrane domain containing 4 2.43423
CBX8 chromobox homolog 8 2.43371
HOXA10 homeobox A10 2.4257
PCDHB13 protocadherin beta 13 2.40814
CDH12 cadherin 12, type 2 (N-cadherin 2) 2.40018
BIN2 bridging integrator 2 2.38072
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.34086
S100A5 S100 calcium binding protein A5 2.33768
RBMS1 RNA binding motif, single stranded interacting protein 1 2.33134
PCDHB12 protocadherin beta 12 2.31851
HOXA11 homeobox A11 2.29193
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 2.29026
CASP8AP2 caspase 8 associated protein 2 2.28537
PROP1 PROP paired-like homeobox 1 2.27603
ULBP2 UL16 binding protein 2 2.257
EXTL2 exostosin-like glycosyltransferase 2 2.21886
FLT3LG fms-related tyrosine kinase 3 ligand 2.21525
NIPAL2 NIPA-like domain containing 2 2.21107
TRPS1 trichorhinophalangeal syndrome I 2.20619
EXD3 exonuclease 3'-5' domain containing 3 2.20487
EN1 engrailed homeobox 1 2.19691
OR51E2 olfactory receptor, family 51, subfamily E, member 2 2.18935
SSX2 synovial sarcoma, X breakpoint 2 2.18683
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.18351
ADGRE1 adhesion G protein-coupled receptor E1 2.17992
MAGEA10 melanoma antigen family A10 2.17569
MIIP migration and invasion inhibitory protein 2.16347
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.1582
HYDIN HYDIN, axonemal central pair apparatus protein 2.15399
NECAP2 NECAP endocytosis associated 2 2.15233
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 2.15111
STX2 syntaxin 2 2.15034
VAV3 vav 3 guanine nucleotide exchange factor 2.14387
ANPEP alanyl (membrane) aminopeptidase 2.12395
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.12004
ZNF133 zinc finger protein 133 2.11238
CXCR6 chemokine (C-X-C motif) receptor 6 2.11221
RTCA RNA 3'-terminal phosphate cyclase 2.10592
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 2.10392
PSRC1 proline/serine-rich coiled-coil 1 2.08993
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.08137
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.07689
CORO2A coronin, actin binding protein, 2A 2.07067
MORN1 MORN repeat containing 1 2.05869
FOXL2 forkhead box L2 2.0575
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 2.05307
ZNF324B zinc finger protein 324B 2.04635
MSMB microseminoprotein, beta- 2.04582
GNL1 guanine nucleotide binding protein-like 1 2.04218
CPLX3 complexin 3 2.02945
MIA melanoma inhibitory activity 2.02569
TMSB15C thymosin beta 15C 2.02464
WIF1 WNT inhibitory factor 1 2.02077
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.01937
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 2.01785
OR1E2 olfactory receptor, family 1, subfamily E, member 2 2.01121
ATG101 autophagy related 101 2.00834
PVRIG poliovirus receptor related immunoglobulin domain containing 2.002
TUBA8 tubulin, alpha 8 2.00035
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 2.00025

decreased expression

Symbol Name Standardized Value
PLK2 polo-like kinase 2 -4.63972
CCNB2 cyclin B2 -4.37406
PCCB propionyl CoA carboxylase, beta polypeptide -4.28247
CDPF1 cysteine-rich, DPF motif domain containing 1 -3.74966
ANXA3 annexin A3 -3.53118
HEATR1 HEAT repeat containing 1 -3.43813
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -3.30425
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -3.09903
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -2.7937
FEM1C fem-1 homolog c (C. elegans) -2.56226
VIM vimentin -2.39524
HPRT1 hypoxanthine phosphoribosyltransferase 1 -2.37838
CTNND1 catenin (cadherin-associated protein), delta 1 -2.27553
TTC38 tetratricopeptide repeat domain 38 -2.22586
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like -2.21956
MICU1 mitochondrial calcium uptake 1 -2.21625
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.20914
AGBL5 ATP/GTP binding protein-like 5 -2.14308
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma -2.1168
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -2.10822
ASL argininosuccinate lyase -2.08714
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) -2.07083
AMACR alpha-methylacyl-CoA racemase -2.04257