CRCGN015_MCF10A_48H:O22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acetamide 105.01 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN015_MCF10A_48H:O22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ELAC2 elaC ribonuclease Z 2 3.29939
PEX11A peroxisomal biogenesis factor 11 alpha 2.44522
KEAP1 kelch-like ECH-associated protein 1 2.43245
DAPL1 death associated protein-like 1 2.30257
BMP4 bone morphogenetic protein 4 2.29932
MOK MOK protein kinase 2.241
CCDC92 coiled-coil domain containing 92 2.19191
MRPS22 mitochondrial ribosomal protein S22 2.11615
CD320 CD320 molecule 2.11392
IPO13 importin 13 2.07634
SKIC2 SKI2 subunit of superkiller complex 2.06494
TMEM109 transmembrane protein 109 2.04637
POLE polymerase (DNA directed), epsilon, catalytic subunit 2.04331
SLC75A1 solute carrier family 75 member 1 2.0202
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.01761
GMPS guanine monphosphate synthase 2.00585

decreased expression

Symbol Name Standardized Value
TM9SF3 transmembrane 9 superfamily member 3 -3.64974
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.23358
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.97286
RALB v-ral simian leukemia viral oncogene homolog B -2.83315
FRS2 fibroblast growth factor receptor substrate 2 -2.75389
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -2.75147
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -2.45919
CLIC4 chloride intracellular channel 4 -2.41706
ABHD17B abhydrolase domain containing 17B -2.15386
AFF4 AF4/FMR2 family, member 4 -2.14552
MAPK1 mitogen-activated protein kinase 1 -2.06447
LAX1 lymphocyte transmembrane adaptor 1 -2.05859
UBXN4 UBX domain protein 4 -2.03444
CREB1 cAMP responsive element binding protein 1 -2.02643
NT5DC2 5'-nucleotidase domain containing 2 -2.0031
MCL1 myeloid cell leukemia 1 -2.0024