CRCGN015_MCF10A_48H:P03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acedapsone 10.92 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

208 genes differentially expressed following the CRCGN015_MCF10A_48H:P03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WIF1 WNT inhibitory factor 1 4.80604
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.62329
TRAPPC4 trafficking protein particle complex 4 3.92
HBA1 hemoglobin, alpha 1 3.30173
CLDN9 claudin 9 3.14168
CETN3 centrin, EF-hand protein, 3 3.02065
VIL1 villin 1 2.91766
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.85823
MPO myeloperoxidase 2.80757
LPAR2 lysophosphatidic acid receptor 2 2.77269
APH1B APH1B gamma secretase subunit 2.71649
DNASE1 deoxyribonuclease I 2.70985
WASF1 WAS protein family, member 1 2.63344
BFSP1 beaded filament structural protein 1, filensin 2.60371
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 2.43899
RNF115 ring finger protein 115 2.42257
LIMD2 LIM domain containing 2 2.40116
GAL3ST1 galactose-3-O-sulfotransferase 1 2.39898
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.39815
CNTFR ciliary neurotrophic factor receptor 2.39425
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.38015
LZTS3 leucine zipper, putative tumor suppressor family member 3 2.35155
GP2 glycoprotein 2 (zymogen granule membrane) 2.35045
ZBTB16 zinc finger and BTB domain containing 16 2.33567
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 2.33367
PCDHB13 protocadherin beta 13 2.32901
CRYGC crystallin, gamma C 2.32087
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 2.31819
NGB neuroglobin 2.31643
CLCNKB chloride channel, voltage-sensitive Kb 2.31007
PTPRS protein tyrosine phosphatase, receptor type, S 2.30844
ZNF35 zinc finger protein 35 2.30191
ARL4A ADP-ribosylation factor-like 4A 2.29673
MKKS McKusick-Kaufman syndrome 2.2922
KLHL12 kelch-like family member 12 2.28123
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 2.27668
GSTT4 glutathione S-transferase theta 4 2.27403
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 2.26123
ARMC7 armadillo repeat containing 7 2.25847
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 2.25661
ELANE elastase, neutrophil expressed 2.24967
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 2.24633
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) 2.24156
SFMBT1 Scm-like with four mbt domains 1 2.2414
HLX H2.0-like homeobox 2.23684
HLA-DOA major histocompatibility complex, class II, DO alpha 2.23021
ILF2 interleukin enhancer binding factor 2 2.2268
UXS1 UDP-glucuronate decarboxylase 1 2.22278
GDF7 growth differentiation factor 7 2.22079
TCN2 transcobalamin II 2.21983
MRPL9 mitochondrial ribosomal protein L9 2.21408
PCDHB3 protocadherin beta 3 2.21299
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 2.20106
SHARPIN SHANK-associated RH domain interactor 2.19952
PDZK1 PDZ domain containing 1 2.19775
OSGEP O-sialoglycoprotein endopeptidase 2.19002
HLA-DRB3 major histocompatibility complex, class II, DR beta 3 2.19001
UBE4A ubiquitination factor E4A 2.18974
NPTN neuroplastin 2.18155
ZNF589 zinc finger protein 589 2.15271
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 2.15178
FGF6 fibroblast growth factor 6 2.14505
BCAS2 breast carcinoma amplified sequence 2 2.13813
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 2.13746
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 2.1248
GSR glutathione reductase 2.12349
TMEM177 transmembrane protein 177 2.12081
AZU1 azurocidin 1 2.12012
CHIA chitinase, acidic 2.12007
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 2.11937
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.11806
TRAM2 translocation associated membrane protein 2 2.10144
MMP2 matrix metallopeptidase 2 2.09808
APOD apolipoprotein D 2.09796
CSF3 colony stimulating factor 3 (granulocyte) 2.09413
EIF1B eukaryotic translation initiation factor 1B 2.09334
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.08964
RGL4 ral guanine nucleotide dissociation stimulator-like 4 2.08752
NSD1 nuclear receptor binding SET domain protein 1 2.07472
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 2.06999
AOC1 amine oxidase, copper containing 1 2.05744
ALX4 ALX homeobox 4 2.05614
MARK1 MAP/microtubule affinity-regulating kinase 1 2.05573
MTERF3 mitochondrial transcription termination factor 3 2.05448
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) 2.05318
TUBA3E tubulin, alpha 3e 2.0498
SNCG synuclein, gamma (breast cancer-specific protein 1) 2.04865
CHRDL1 chordin-like 1 2.04729
FKBP9 FK506 binding protein 9, 63 kDa 2.04174
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) 2.03595
WDR3 WD repeat domain 3 2.03224
CKS1B CDC28 protein kinase regulatory subunit 1B 2.03179
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 2.03054
TM2D3 TM2 domain containing 3 2.02784
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 2.02739
ZNF721 zinc finger protein 721 2.0233
PRTN3 proteinase 3 2.02251
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae) 2.01954
ACTL7B actin-like 7B 2.01891
NFRKB nuclear factor related to kappaB binding protein 2.01695
DEGS1 delta(4)-desaturase, sphingolipid 1 2.01667
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.0162
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 2.01523
NUTF2 nuclear transport factor 2 2.0143
PCOLCE2 procollagen C-endopeptidase enhancer 2 2.01297
PITX3 paired-like homeodomain 3 2.00343
CATSPERZ catsper channel auxiliary subunit zeta 2.00255
CLUL1 clusterin-like 1 (retinal) 2.00148
SLC4A2 solute carrier family 4 (anion exchanger), member 2 2.00129

decreased expression

Symbol Name Standardized Value
CREG1 cellular repressor of E1A-stimulated genes 1 -5.95766
RALGDS ral guanine nucleotide dissociation stimulator -5.38067
KCNK1 potassium channel, two pore domain subfamily K, member 1 -5.36773
HMG20B high mobility group 20B -5.30975
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.87617
MRPS2 mitochondrial ribosomal protein S2 -4.68694
NLRP4 NLR family, pyrin domain containing 4 -4.17931
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -3.96526
KRT7 keratin 7, type II -3.50292
CLTB clathrin, light chain B -3.48434
PLSCR3 phospholipid scramblase 3 -3.20665
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -3.15948
ATG4A autophagy related 4A, cysteine peptidase -2.94027
SEC61B Sec61 beta subunit -2.87682
HOXA5 homeobox A5 -2.75033
MT2A metallothionein 2A -2.73902
MGMT O-6-methylguanine-DNA methyltransferase -2.68208
FGFBP1 fibroblast growth factor binding protein 1 -2.66819
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.66475
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.6352
LDLRAP1 low density lipoprotein receptor adaptor protein 1 -2.61902
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.61835
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 -2.60617
RABEPK Rab9 effector protein with kelch motifs -2.60066
MELK maternal embryonic leucine zipper kinase -2.5772
SNX7 sorting nexin 7 -2.56987
CEMIP cell migration inducing protein, hyaluronan binding -2.53773
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.5072
ZC2HC1A zinc finger, C2HC-type containing 1A -2.50428
MKS1 Meckel syndrome, type 1 -2.48505
HGS hepatocyte growth factor-regulated tyrosine kinase substrate -2.47058
HOXA1 homeobox A1 -2.46217
IER2 immediate early response 2 -2.45684
SECISBP2 SECIS binding protein 2 -2.45649
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 -2.44951
PCTP phosphatidylcholine transfer protein -2.44886
ZNF510 zinc finger protein 510 -2.42788
AVPI1 arginine vasopressin-induced 1 -2.4256
PECR peroxisomal trans-2-enoyl-CoA reductase -2.42156
DENND1C DENN/MADD domain containing 1C -2.38118
BACE2 beta-site APP-cleaving enzyme 2 -2.37941
ABHD17A abhydrolase domain containing 17A -2.37913
CD247 CD247 molecule -2.37618
KIF20A kinesin family member 20A -2.36704
VCP valosin containing protein -2.36238
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -2.35387
PARP16 poly (ADP-ribose) polymerase family, member 16 -2.34472
MOSPD2 motile sperm domain containing 2 -2.32561
KRT6A keratin 6A, type II -2.31964
LOC102724023 ES1 protein homolog, mitochondrial -2.31504
MYDGF myeloid-derived growth factor -2.31362
SPRR1B small proline-rich protein 1B -2.27497
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 -2.26173
URM1 ubiquitin related modifier 1 -2.25523
HOXA7 homeobox A7 -2.25248
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.24813
PILRB paired immunoglobin-like type 2 receptor beta -2.24104
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 -2.23224
CANT1 calcium activated nucleotidase 1 -2.20989
PYGB phosphorylase, glycogen; brain -2.20099
CTSV cathepsin V -2.19949
PLCD1 phospholipase C, delta 1 -2.18898
NR1D1 nuclear receptor subfamily 1, group D, member 1 -2.18523
PITX1 paired-like homeodomain 1 -2.17749
SYNGR2 synaptogyrin 2 -2.17669
FOXC1 forkhead box C1 -2.17539
KRT17 keratin 17, type I -2.15158
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -2.15048
FKBP11 FK506 binding protein 11, 19 kDa -2.14469
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.14224
PINK1 PTEN induced putative kinase 1 -2.13644
PLK2 polo-like kinase 2 -2.13238
IRF1 interferon regulatory factor 1 -2.129
BIRC2 baculoviral IAP repeat containing 2 -2.12823
ETHE1 ethylmalonic encephalopathy 1 -2.12663
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A -2.12309
BMAL1 basic helix-loop-helix ARNT like 1 -2.11915
KAT2A K(lysine) acetyltransferase 2A -2.11259
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -2.1085
PWWP3A PWWP domain containing 3A, DNA repair factor -2.10163
GPR87 G protein-coupled receptor 87 -2.09647
ADRB2 adrenoceptor beta 2, surface -2.09232
CLTA clathrin, light chain A -2.08732
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 -2.08479
FOXE1 forkhead box E1 -2.07481
PPP1R13L protein phosphatase 1, regulatory subunit 13 like -2.06826
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 -2.06664
P4HB prolyl 4-hydroxylase, beta polypeptide -2.05596
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.04993
DUOX2 dual oxidase 2 -2.03894
MORC4 MORC family CW-type zinc finger 4 -2.03605
NELFB negative elongation factor complex member B -2.03217
NANS N-acetylneuraminic acid synthase -2.03204
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -2.02847
ANXA8L1 annexin A8-like 1 -2.02306
DSG3 desmoglein 3 -2.01947
KLF5 Kruppel-like factor 5 (intestinal) -2.01886
TASP1 taspase, threonine aspartase, 1 -2.01812
ZNF593 zinc finger protein 593 -2.01028