CRCGN015_MCF10A_48H:P09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-aminodiphenyl 11.12 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN015_MCF10A_48H:P09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 6.41325
MAST2 microtubule associated serine/threonine kinase 2 2.87448
BEX3 brain expressed X-linked 3 2.6009
PYCR1 pyrroline-5-carboxylate reductase 1 2.52363
TSPAN8 tetraspanin 8 2.39165
TWNK twinkle mtDNA helicase 2.37774
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 2.28728
MTARC1 mitochondrial amidoxime reducing component 1 2.19879
CDK19 cyclin-dependent kinase 19 2.12912
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 2.0938
USP9X ubiquitin specific peptidase 9, X-linked 2.06858
PALS2 protein associated with LIN7 2, MAGUK p55 family member 2.04796

decreased expression

Symbol Name Standardized Value
S100A8 S100 calcium binding protein A8 -4.78147
OAT ornithine aminotransferase -4.27702
YME1L1 YME1-like 1 ATPase -4.12467
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.84013
UFM1 ubiquitin-fold modifier 1 -3.56015
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.55061
ATP11B ATPase, class VI, type 11B -3.30956
VDAC1 voltage-dependent anion channel 1 -3.08244
LDHD lactate dehydrogenase D -3.08065
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 -2.84996
TXNDC9 thioredoxin domain containing 9 -2.84721
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 -2.7344
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.53787
BIN3 bridging integrator 3 -2.531
ARF5 ADP-ribosylation factor 5 -2.48121
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 -2.46948
ABI1 abl-interactor 1 -2.43842
ARMC1 armadillo repeat containing 1 -2.43323
HPRT1 hypoxanthine phosphoribosyltransferase 1 -2.37313
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.34225
GDI2 GDP dissociation inhibitor 2 -2.3417
BAX BCL2-associated X protein -2.33374
RIOK3 RIO kinase 3 -2.30315
TMEM131 transmembrane protein 131 -2.30297
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 -2.26279
ZNF212 zinc finger protein 212 -2.26274
STARD7 StAR-related lipid transfer (START) domain containing 7 -2.18675
ZC3H15 zinc finger CCCH-type containing 15 -2.1735
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -2.15834
ACO2 aconitase 2, mitochondrial -2.14936
SH2D2A SH2 domain containing 2A -2.14502
ANKRD26 ankyrin repeat domain 26 -2.13623
KRT33B keratin 33B, type I -2.13407
MED4 mediator complex subunit 4 -2.12349
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) -2.09462
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -2.07052
ATP5MC3 ATP synthase membrane subunit c locus 3 -2.07021
RGPD2 RANBP2-like and GRIP domain containing 2 -2.06604
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -2.06479
RBM28 RNA binding motif protein 28 -2.05545
PDCL3 phosducin-like 3 -2.04738
RINT1 RAD50 interactor 1 -2.04732
SCFD1 sec1 family domain containing 1 -2.02915
CLUH clustered mitochondria (cluA/CLU1) homolog -2.01236
CTNNBIP1 catenin, beta interacting protein 1 -2.00801
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit -2.00761
DUSP5 dual specificity phosphatase 5 -2.00032