CRCGN015_MCF10A_48H:P10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description megestrol 99.64 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

23 genes differentially expressed following the CRCGN015_MCF10A_48H:P10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
VAV3 vav 3 guanine nucleotide exchange factor 3.18893
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 2.41735
MOK MOK protein kinase 2.32002
IL4R interleukin 4 receptor 2.27608
TLCD3A TLC domain containing 3A 2.19513
FNDC3B fibronectin type III domain containing 3B 2.1463

decreased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic -3.88336
SLC25A46 solute carrier family 25, member 46 -3.70062
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.50144
NUP85 nucleoporin 85kDa -2.87041
CREG1 cellular repressor of E1A-stimulated genes 1 -2.51699
TCEAL4 transcription elongation factor A (SII)-like 4 -2.49843
RGS2 regulator of G-protein signaling 2 -2.43764
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -2.29314
MRPS7 mitochondrial ribosomal protein S7 -2.29055
NT5C 5', 3'-nucleotidase, cytosolic -2.18284
ATP5MC3 ATP synthase membrane subunit c locus 3 -2.16947
PLK2 polo-like kinase 2 -2.13558
SUMO4 small ubiquitin-like modifier 4 -2.12498
TMEM147 transmembrane protein 147 -2.07475
ZNF394 zinc finger protein 394 -2.07444
OGDHL oxoglutarate dehydrogenase-like -2.00569
EMD emerin -2.00143