CRCGN015_MCF10A_48H:P11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description megestrol 33.21 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

171 genes differentially expressed following the CRCGN015_MCF10A_48H:P11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUCB2 nucleobindin 2 5.48097
ADO 2-aminoethanethiol (cysteamine) dioxygenase 5.26076
RNPS1 RNA binding protein S1, serine-rich domain 4.35777
BAX BCL2-associated X protein 3.9727
EMSY EMSY transcriptional repressor, BRCA2 interacting 3.23661
RSF1 remodeling and spacing factor 1 3.22601
WASF3 WAS protein family, member 3 3.02799
TFF3 trefoil factor 3 (intestinal) 2.98931
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 2.89519
TBC1D12 TBC1 domain family, member 12 2.77144
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 2.7697
PARP1 poly (ADP-ribose) polymerase 1 2.65253
MOK MOK protein kinase 2.59135
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.58796
MTREX Mtr4 exosome RNA helicase 2.52147
NEO1 neogenin 1 2.43997
TMA16 translation machinery associated 16 homolog (S. cerevisiae) 2.42424
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 2.41281
DNA2 DNA replication helicase/nuclease 2 2.40929
XPO6 exportin 6 2.40467
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.38787
BACE1 beta-site APP-cleaving enzyme 1 2.37898
CPEB3 cytoplasmic polyadenylation element binding protein 3 2.37593
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 2.36958
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.33497
TCF12 transcription factor 12 2.33284
GOLGA8N golgin A8 family, member N 2.31785
PFAS phosphoribosylformylglycinamidine synthase 2.30731
TTC31 tetratricopeptide repeat domain 31 2.27096
KIF16B kinesin family member 16B 2.25044
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.23523
PENK proenkephalin 2.20891
RBM23 RNA binding motif protein 23 2.20797
PKN1 protein kinase N1 2.19994
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like 2.19977
NSD2 nuclear receptor binding SET domain protein 2 2.1899
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.18626
RNF4 ring finger protein 4 2.1814
TSPYL5 TSPY-like 5 2.17179
MOGS mannosyl-oligosaccharide glucosidase 2.16176
SCRN1 secernin 1 2.1527
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.13425
ZNF112 zinc finger protein 112 2.10995
COQ8A coenzyme Q8A 2.10688
ADAR adenosine deaminase, RNA-specific 2.1034
CD70 CD70 molecule 2.09236
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 2.08005
SUSD5 sushi domain containing 5 2.07721
PLCE1 phospholipase C, epsilon 1 2.07301
GNPAT glyceronephosphate O-acyltransferase 2.06568
JRKL JRK-like 2.06214
PGM1 phosphoglucomutase 1 2.06213
EFL1 elongation factor like GTPase 1 2.0609
SPDL1 spindle apparatus coiled-coil protein 1 2.05126
FOCAD focadhesin 2.04361
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 2.0373
POMK protein-O-mannose kinase 2.02839
DNMBP dynamin binding protein 2.01858
GPD1L glycerol-3-phosphate dehydrogenase 1-like 2.01697
CD302 CD302 molecule 2.0136

decreased expression

Symbol Name Standardized Value
S100A8 S100 calcium binding protein A8 -6.13224
UFM1 ubiquitin-fold modifier 1 -5.23095
GTPBP8 GTP-binding protein 8 (putative) -5.0706
ENOPH1 enolase-phosphatase 1 -3.97711
SLC35F2 solute carrier family 35, member F2 -3.90926
MT2A metallothionein 2A -3.5679
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.45063
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.36752
RPP40 ribonuclease P/MRP 40kDa subunit -3.0859
ZNF593 zinc finger protein 593 -2.8857
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 -2.81614
MSMO1 methylsterol monooxygenase 1 -2.80705
PLD2 phospholipase D2 -2.77589
BLVRB biliverdin reductase B -2.75313
MRPS31 mitochondrial ribosomal protein S31 -2.74281
RBX1 ring-box 1, E3 ubiquitin protein ligase -2.73051
ELL2 elongation factor, RNA polymerase II, 2 -2.70409
RGS2 regulator of G-protein signaling 2 -2.69017
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -2.64613
PAK1IP1 PAK1 interacting protein 1 -2.63247
ZNF669 zinc finger protein 669 -2.61972
MYZAP myocardial zonula adherens protein -2.58179
HS1BP3 HCLS1 binding protein 3 -2.56185
MRPS10 mitochondrial ribosomal protein S10 -2.55605
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.53752
CTSB cathepsin B -2.52155
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 -2.51454
FLCN folliculin -2.47693
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 -2.47506
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -2.45681
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -2.4485
ETHE1 ethylmalonic encephalopathy 1 -2.4377
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -2.43292
ND5 NADH dehydrogenase subunit 5 -2.41816
GSTO1 glutathione S-transferase omega 1 -2.41797
DES desmin -2.4125
MAPT microtubule-associated protein tau -2.37845
TMEM14B transmembrane protein 14B -2.36979
NOP10 NOP10 ribonucleoprotein -2.3687
CRNN cornulin -2.36685
HSPB6 heat shock protein, alpha-crystallin-related, B6 -2.35092
MCC mutated in colorectal cancers -2.34826
GMFG glia maturation factor, gamma -2.34402
BIRC3 baculoviral IAP repeat containing 3 -2.34196
TCEAL4 transcription elongation factor A (SII)-like 4 -2.3156
UNC119 unc-119 homolog (C. elegans) -2.303
CA14 carbonic anhydrase XIV -2.28761
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -2.28078
PLK2 polo-like kinase 2 -2.27106
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide -2.2625
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -2.26224
PDLIM1 PDZ and LIM domain 1 -2.23853
MAGT1 magnesium transporter 1 -2.23336
TSC22D3 TSC22 domain family, member 3 -2.22979
OARD1 O-acyl-ADP-ribose deacylase 1 -2.2115
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa -2.20784
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 -2.20006
NCS1 neuronal calcium sensor 1 -2.19792
CSRP2 cysteine and glycine-rich protein 2 -2.1958
GFUS GDP-L-fucose synthase -2.18485
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -2.18299
RGS1 regulator of G-protein signaling 1 -2.18112
SEM1 SEM1 26S proteasome subunit -2.17755
POMP proteasome maturation protein -2.1745
LYRM4 LYR motif containing 4 -2.17352
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.16952
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.16636
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -2.16232
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -2.16003
CIAO2B cytosolic iron-sulfur assembly component 2B -2.15819
MOGAT1 monoacylglycerol O-acyltransferase 1 -2.15524
SDAD1 SDA1 domain containing 1 -2.15045
AP1AR adaptor-related protein complex 1 associated regulatory protein -2.15006
NSUN3 NOP2/Sun domain family, member 3 -2.1491
CHMP5 charged multivesicular body protein 5 -2.13884
PLA2G2D phospholipase A2, group IID -2.13867
CGGBP1 CGG triplet repeat binding protein 1 -2.13261
RAB7A RAB7A, member RAS oncogene family -2.12893
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.1194
GCLC glutamate-cysteine ligase, catalytic subunit -2.10559
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -2.10219
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.09912
VSIG4 V-set and immunoglobulin domain containing 4 -2.09678
CD38 CD38 molecule -2.09361
ZMYM5 zinc finger, MYM-type 5 -2.09065
LOC107987462 leukocyte immunoglobulin-like receptor subfamily B member 3 -2.09019
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 -2.08977
ZNF394 zinc finger protein 394 -2.08716
GUK1 guanylate kinase 1 -2.08712
PDCL3 phosducin-like 3 -2.08638
CHMP2B charged multivesicular body protein 2B -2.08429
CEP170B centrosomal protein 170B -2.07074
STAC SH3 and cysteine rich domain -2.06961
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -2.06865
MAD2L1BP MAD2L1 binding protein -2.06707
RENBP renin binding protein -2.06255
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.04223
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -2.04214
KLF3 Kruppel-like factor 3 (basic) -2.03578
TGIF1 TGFB-induced factor homeobox 1 -2.02782
GTF3A general transcription factor IIIA -2.02228
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -2.01881
HIPK3 homeodomain interacting protein kinase 3 -2.01391
LIAS lipoic acid synthetase -2.0132
VASP vasodilator-stimulated phosphoprotein -2.01244
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent -2.0102
IKZF5 IKAROS family zinc finger 5 (Pegasus) -2.00904
SREBF1 sterol regulatory element binding transcription factor 1 -2.0075
CLIP2 CAP-GLY domain containing linker protein 2 -2.00346
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -2.00313
BARX2 BARX homeobox 2 -2.00201