CRCGN015_MCF10A_48H:P14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description uracil mustard 33.81 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

114 genes differentially expressed following the CRCGN015_MCF10A_48H:P14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 5.22582
CNPY3 canopy FGF signaling regulator 3 3.51957
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.37337
WIF1 WNT inhibitory factor 1 3.2391
SCAND1 SCAN domain containing 1 3.22033
PANK2 pantothenate kinase 2 3.18055
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.96962
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 2.88324
TXNL4B thioredoxin-like 4B 2.74762
TLCD3A TLC domain containing 3A 2.61296
EVL Enah/Vasp-like 2.60539
MSRA methionine sulfoxide reductase A 2.46912
SESN1 sestrin 1 2.44641
DDB2 damage-specific DNA binding protein 2, 48kDa 2.44438
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 2.44153
MEA1 male-enhanced antigen 1 2.43005
BLCAP bladder cancer associated protein 2.37928
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.37632
GRB10 growth factor receptor-bound protein 10 2.36904
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.34959
CIDEB cell death-inducing DFFA-like effector b 2.28462
NPDC1 neural proliferation, differentiation and control, 1 2.2801
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 2.21808
KLHL21 kelch-like family member 21 2.21665
HAGH hydroxyacylglutathione hydrolase 2.17382
IFI27 interferon, alpha-inducible protein 27 2.14001
CUTA cutA divalent cation tolerance homolog (E. coli) 2.12754
FHL2 four and a half LIM domains 2 2.09474
MICB MHC class I polypeptide-related sequence B 2.05754
NME3 NME/NM23 nucleoside diphosphate kinase 3 2.05693
NGRN neugrin, neurite outgrowth associated 2.0305
MMP24-AS1-EDEM2 MMP24-AS1-EDEM2 readthrough 2.02548
GADD45A growth arrest and DNA-damage-inducible, alpha 2.01894
TP53I3 tumor protein p53 inducible protein 3 2.00884
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.00784

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -4.9011
PLK1 polo-like kinase 1 -4.29554
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.16598
COG2 component of oligomeric golgi complex 2 -4.03492
CCNB2 cyclin B2 -3.91204
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.83802
LBR lamin B receptor -3.37346
TEX10 testis expressed 10 -3.16531
LIAS lipoic acid synthetase -3.13567
RBM28 RNA binding motif protein 28 -3.04149
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.87713
TOP2A topoisomerase (DNA) II alpha 170kDa -2.86371
CDKN2AIP CDKN2A interacting protein -2.8524
ZNF83 zinc finger protein 83 -2.77979
KIF20A kinesin family member 20A -2.72423
EXOSC8 exosome component 8 -2.70293
NLRP2 NLR family, pyrin domain containing 2 -2.6909
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.68637
RXYLT1 ribitol xylosyltransferase 1 -2.62331
CCNB1 cyclin B1 -2.61486
ARMC1 armadillo repeat containing 1 -2.59618
CCNA2 cyclin A2 -2.58677
NEK2 NIMA-related kinase 2 -2.57672
ENTR1 endosome associated trafficking regulator 1 -2.49128
INTS5 integrator complex subunit 5 -2.45407
AP1AR adaptor-related protein complex 1 associated regulatory protein -2.45067
ANAPC10 anaphase promoting complex subunit 10 -2.43691
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -2.42966
PUS3 pseudouridylate synthase 3 -2.42255
MRPL15 mitochondrial ribosomal protein L15 -2.39339
TMEM100 transmembrane protein 100 -2.3925
PSRC1 proline/serine-rich coiled-coil 1 -2.37777
UFSP2 UFM1-specific peptidase 2 -2.36436
NAT10 N-acetyltransferase 10 (GCN5-related) -2.36349
MRPS2 mitochondrial ribosomal protein S2 -2.35973
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -2.35548
SLC25A46 solute carrier family 25, member 46 -2.34581
FASTKD1 FAST kinase domains 1 -2.34105
RCC1 regulator of chromosome condensation 1 -2.31116
SREK1IP1 SREK1-interacting protein 1 -2.29858
OBI1 ORC ubiquitin ligase 1 -2.27999
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.27679
BIRC5 baculoviral IAP repeat containing 5 -2.27363
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled -2.23219
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 -2.21447
PRPF19 pre-mRNA processing factor 19 -2.20366
KIF3A kinesin family member 3A -2.1842
MED28 mediator complex subunit 28 -2.1816
KIF4A kinesin family member 4A -2.17748
ZSCAN5A zinc finger and SCAN domain containing 5A -2.17094
CENPA centromere protein A -2.1676
HMGB2 high mobility group box 2 -2.15591
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.14816
TMEM38B transmembrane protein 38B -2.14335
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -2.14073
CCT4 chaperonin containing TCP1, subunit 4 (delta) -2.13553
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) -2.11714
SMAD5 SMAD family member 5 -2.11707
UBE2C ubiquitin-conjugating enzyme E2C -2.10418
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.08536
KLF10 Kruppel-like factor 10 -2.08486
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.07693
MANEA mannosidase, endo-alpha -2.07241
ISOC1 isochorismatase domain containing 1 -2.05732
TTK TTK protein kinase -2.05053
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -2.04929
MRPL19 mitochondrial ribosomal protein L19 -2.04643
PRMT3 protein arginine methyltransferase 3 -2.0433
WDR82 WD repeat domain 82 -2.04201
WWC2 WW and C2 domain containing 2 -2.04095
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.03578
MTUS1 microtubule associated tumor suppressor 1 -2.03542
GTPBP8 GTP-binding protein 8 (putative) -2.02544
DEPDC1 DEP domain containing 1 -2.02071
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.01761
HEATR1 HEAT repeat containing 1 -2.01425
INTS7 integrator complex subunit 7 -2.0113
MRPS31 mitochondrial ribosomal protein S31 -2.00612
COPS5 COP9 signalosome subunit 5 -2.00068