CRCGN016_MCF10A.TP53.M_24H:A13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,2',4,4',5,5'-hexachloro-1,1'-biphenyl 98.52 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

24 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:A13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 4.97962
GADD45A growth arrest and DNA-damage-inducible, alpha 3.66367
INTS3 integrator complex subunit 3 3.36833
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.81307
ACAA1 acetyl-CoA acyltransferase 1 2.75924
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.73662
HMOX1 heme oxygenase 1 2.57482
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.55498
CETN3 centrin, EF-hand protein, 3 2.34125

decreased expression

Symbol Name Standardized Value
HOXA5 homeobox A5 -5.13008
CHMP4B charged multivesicular body protein 4B -4.73062
KRT14 keratin 14, type I -4.48975
PUF60 poly-U binding splicing factor 60KDa -4.47367
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.22516
PGAM4 phosphoglycerate mutase family member 4 -3.23021
CBR3 carbonyl reductase 3 -3.13475
PCNA proliferating cell nuclear antigen -2.93543
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.8128
LYPLA1 lysophospholipase I -2.64564
UBE3C ubiquitin protein ligase E3C -2.43659
STXBP2 syntaxin binding protein 2 -2.26015
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough -2.22788
VDAC1 voltage-dependent anion channel 1 -2.21363
DNAAF11 dynein axonemal assembly factor 11 -2.15216