CRCGN016_MCF10A.TP53.M_24H:A15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,2',4,4',5,5'-hexachloro-1,1'-biphenyl 10.95 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

22 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:A15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FKBP14 FK506 binding protein 14, 22 kDa 4.69895
SPAG4 sperm associated antigen 4 4.37206
CCL2 chemokine (C-C motif) ligand 2 4.27445
HLA-DRA major histocompatibility complex, class II, DR alpha 4.20929
MAP7 microtubule-associated protein 7 4.19256
HBA1 hemoglobin, alpha 1 3.28832
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.69356
TIAM1 T-cell lymphoma invasion and metastasis 1 2.53235
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.49449
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.39113
KDM5D lysine (K)-specific demethylase 5D 2.36982
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.0937

decreased expression

Symbol Name Standardized Value
ENOPH1 enolase-phosphatase 1 -4.55056
CCDC86 coiled-coil domain containing 86 -4.34982
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.05422
HMG20B high mobility group 20B -4.01985
RPA3 replication protein A3, 14kDa -2.66063
MT1X metallothionein 1X -2.62127
SMC1A structural maintenance of chromosomes 1A -2.34706
GDF15 growth differentiation factor 15 -2.29118
MT2A metallothionein 2A -2.27903
NLRP4 NLR family, pyrin domain containing 4 -2.10427