| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | n-hydroxy-2-acetylamino?fluorene 11.1 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome) |
| Similar Terms | |
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271 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:A21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 8.8509 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 8.17935 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 6.8094 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 6.78841 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 5.49927 |
| AARS1 | alanyl-tRNA synthetase 1 | 5.43287 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 4.95288 |
| PSAT1 | phosphoserine aminotransferase 1 | 4.94362 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 4.49423 |
| PHGDH | phosphoglycerate dehydrogenase | 4.46198 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 4.39046 |
| TXLNA | taxilin alpha | 4.28942 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 4.10678 |
| CARS1 | cysteinyl-tRNA synthetase 1 | 4.00999 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 3.88418 |
| SHMT2 | serine hydroxymethyltransferase 2 (mitochondrial) | 3.86829 |
| XPOT | exportin, tRNA | 3.6984 |
| FHL2 | four and a half LIM domains 2 | 3.58755 |
| CEBPG | CCAAT/enhancer binding protein (C/EBP), gamma | 3.52741 |
| TRIB3 | tribbles pseudokinase 3 | 3.52271 |
| SARS1 | seryl-tRNA synthetase 1 | 3.5064 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | 3.49089 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 3.46043 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 3.3442 |
| ATF4 | activating transcription factor 4 | 3.29947 |
| TBX2 | T-box 2 | 3.29404 |
| TICAM1 | toll-like receptor adaptor molecule 1 | 3.28123 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | 3.26624 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 3.25846 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 3.21417 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 3.19497 |
| HMOX1 | heme oxygenase 1 | 3.18036 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 3.05592 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 | 3.02728 |
| KIF5C | kinesin family member 5C | 3.02464 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | 3.00849 |
| NIBAN1 | niban apoptosis regulator 1 | 2.9974 |
| LOC128125814 | uncharacterized LOC128125814 | 2.99264 |
| TCEA2 | transcription elongation factor A (SII), 2 | 2.96211 |
| MARS1 | methionyl-tRNA synthetase 1 | 2.95825 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | 2.89203 |
| STAMBP | STAM binding protein | 2.89151 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.85557 |
| VSIG2 | V-set and immunoglobulin domain containing 2 | 2.82512 |
| TP53BP2 | tumor protein p53 binding protein 2 | 2.81012 |
| LYRM1 | LYR motif containing 1 | 2.77708 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | 2.74 |
| RAP1GAP | RAP1 GTPase activating protein | 2.73669 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 2.73324 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 2.71567 |
| STC2 | stanniocalcin 2 | 2.68925 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 2.6831 |
| LOC102724560 | cystathionine beta-synthase | 2.67738 |
| MUTYH | mutY homolog | 2.6773 |
| TNIP1 | TNFAIP3 interacting protein 1 | 2.66154 |
| ZCCHC8 | zinc finger, CCHC domain containing 8 | 2.64949 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | 2.62808 |
| AGR2 | anterior gradient 2 | 2.62731 |
| GARS1 | glycyl-tRNA synthetase 1 | 2.59858 |
| APOL6 | apolipoprotein L, 6 | 2.59665 |
| INTS3 | integrator complex subunit 3 | 2.55393 |
| IFRD1 | interferon-related developmental regulator 1 | 2.55015 |
| WWC3 | WWC family member 3 | 2.52758 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | 2.5213 |
| VLDLR | very low density lipoprotein receptor | 2.51645 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 2.50969 |
| VPS4A | vacuolar protein sorting 4 homolog A (S. cerevisiae) | 2.50362 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 2.47399 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 2.46737 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.44098 |
| ELAC2 | elaC ribonuclease Z 2 | 2.43821 |
| G0S2 | G0/G1 switch 2 | 2.41755 |
| CALCB | calcitonin-related polypeptide beta | 2.39492 |
| AKAP17A | A kinase (PRKA) anchor protein 17A | 2.37658 |
| TXNRD1 | thioredoxin reductase 1 | 2.36949 |
| NCBP3 | nuclear cap binding subunit 3 | 2.35629 |
| GTPBP2 | GTP binding protein 2 | 2.3317 |
| ERP29 | endoplasmic reticulum protein 29 | 2.32313 |
| GNA15 | guanine nucleotide binding protein (G protein), alpha 15 (Gq class) | 2.32193 |
| RGS2 | regulator of G-protein signaling 2 | 2.31864 |
| LCAT | lecithin-cholesterol acyltransferase | 2.30928 |
| GLRX | glutaredoxin (thioltransferase) | 2.25747 |
| SHFL | shiftless antiviral inhibitor of ribosomal frameshifting | 2.24968 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 2.24646 |
| ITPKB | inositol-trisphosphate 3-kinase B | 2.24463 |
| TRIT1 | tRNA isopentenyltransferase 1 | 2.23854 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 2.23444 |
| BLCAP | bladder cancer associated protein | 2.22767 |
| YTHDC1 | YTH domain containing 1 | 2.2256 |
| DENND2D | DENN/MADD domain containing 2D | 2.20856 |
| RANGRF | RAN guanine nucleotide release factor | 2.20756 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 2.20555 |
| S100P | S100 calcium binding protein P | 2.20128 |
| WFS1 | Wolfram syndrome 1 (wolframin) | 2.17125 |
| COL9A2 | collagen, type IX, alpha 2 | 2.15305 |
| ADRB2 | adrenoceptor beta 2, surface | 2.15081 |
| MYBBP1A | MYB binding protein (P160) 1a | 2.1452 |
| KDM5D | lysine (K)-specific demethylase 5D | 2.14327 |
| LYPLA1-TCEA1 | LYPLA1-TCEA1 readthrough | 2.1402 |
| FBXO46 | F-box protein 46 | 2.13689 |
| B4GALT4 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 | 2.13086 |
| NLRX1 | NLR family member X1 | 2.1214 |
| ZFPM1 | zinc finger protein, FOG family member 1 | 2.11896 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 2.11572 |
| TMEM268 | transmembrane protein 268 | 2.11087 |
| TARS1 | threonyl-tRNA synthetase 1 | 2.10858 |
| ATF3 | activating transcription factor 3 | 2.09992 |
| TIMM44 | translocase of inner mitochondrial membrane 44 homolog (yeast) | 2.09286 |
| CMTR1 | cap methyltransferase 1 | 2.07804 |
| LONP1 | lon peptidase 1, mitochondrial | 2.07392 |
| RCN1 | reticulocalbin 1, EF-hand calcium binding domain | 2.07283 |
| TPBG | trophoblast glycoprotein | 2.07125 |
| TFF2 | trefoil factor 2 | 2.06947 |
| COG4 | component of oligomeric golgi complex 4 | 2.06652 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 2.05146 |
| CSRP1 | cysteine and glycine-rich protein 1 | 2.04818 |
| CAMTA2 | calmodulin binding transcription activator 2 | 2.04799 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 2.03623 |
| SPAG7 | sperm associated antigen 7 | 2.01912 |
| YIPF1 | Yip1 domain family, member 1 | 2.01697 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 2.00867 |
| RAB4B | RAB4B, member RAS oncogene family | 2.00048 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CYCS | cytochrome c, somatic | -6.13414 |
| MSMO1 | methylsterol monooxygenase 1 | -5.45237 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -5.21018 |
| DSG2 | desmoglein 2 | -5.0787 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -4.68169 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -4.59565 |
| CCNB2 | cyclin B2 | -4.20079 |
| S100A4 | S100 calcium binding protein A4 | -4.17297 |
| SCYL3 | SCY1-like 3 (S. cerevisiae) | -4.10942 |
| KIF20A | kinesin family member 20A | -4.03448 |
| NUP85 | nucleoporin 85kDa | -4.01016 |
| MRPS7 | mitochondrial ribosomal protein S7 | -3.8084 |
| HOXA5 | homeobox A5 | -3.78326 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -3.72866 |
| CCNB1 | cyclin B1 | -3.65454 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -3.59794 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -3.52631 |
| BIRC5 | baculoviral IAP repeat containing 5 | -3.37041 |
| PLK1 | polo-like kinase 1 | -3.35759 |
| CBX3 | chromobox homolog 3 | -3.34119 |
| SUMO4 | small ubiquitin-like modifier 4 | -3.32652 |
| INSIG1 | insulin induced gene 1 | -3.12677 |
| BZW2 | basic leucine zipper and W2 domains 2 | -3.11812 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | -3.00046 |
| CDC20 | cell division cycle 20 | -2.96654 |
| HSPA8 | heat shock 70kDa protein 8 | -2.93538 |
| KCTD2 | potassium channel tetramerization domain containing 2 | -2.92467 |
| PRCP | prolylcarboxypeptidase (angiotensinase C) | -2.92035 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -2.90013 |
| TEX10 | testis expressed 10 | -2.88852 |
| ZMYM1 | zinc finger, MYM-type 1 | -2.88659 |
| H2BC12 | H2B clustered histone 12 | -2.84402 |
| UQCR10 | ubiquinol-cytochrome c reductase, complex III subunit X | -2.82691 |
| GEMIN6 | gem (nuclear organelle) associated protein 6 | -2.80945 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | -2.79914 |
| HSPA1A | heat shock 70kDa protein 1A | -2.79358 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -2.78105 |
| ATP5PD | ATP synthase peripheral stalk subunit d | -2.76192 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | -2.7465 |
| ZNF557 | zinc finger protein 557 | -2.74209 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | -2.72939 |
| SMIM8 | small integral membrane protein 8 | -2.72296 |
| ZSCAN5A | zinc finger and SCAN domain containing 5A | -2.72126 |
| DEPDC1 | DEP domain containing 1 | -2.71684 |
| KIF18A | kinesin family member 18A | -2.70884 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) | -2.70759 |
| ZNF274 | zinc finger protein 274 | -2.69851 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -2.69393 |
| RPA3 | replication protein A3, 14kDa | -2.6749 |
| NOL11 | nucleolar protein 11 | -2.64148 |
| C1GALT1C1 | C1GALT1-specific chaperone 1 | -2.62396 |
| BCCIP | BRCA2 and CDKN1A interacting protein | -2.61451 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -2.61189 |
| PCOLCE2 | procollagen C-endopeptidase enhancer 2 | -2.60665 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.60198 |
| CCNA2 | cyclin A2 | -2.57748 |
| PGM1 | phosphoglucomutase 1 | -2.55088 |
| AURKA | aurora kinase A | -2.5371 |
| TUBA4A | tubulin, alpha 4a | -2.53539 |
| EID1 | EP300 interacting inhibitor of differentiation 1 | -2.51366 |
| SESN1 | sestrin 1 | -2.51127 |
| H2BC9 | H2B clustered histone 9 | -2.47989 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -2.46331 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -2.46253 |
| SGMS1 | sphingomyelin synthase 1 | -2.46082 |
| CDC25C | cell division cycle 25C | -2.45763 |
| CBR1 | carbonyl reductase 1 | -2.44756 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | -2.43213 |
| KIF14 | kinesin family member 14 | -2.41772 |
| ANXA2 | annexin A2 | -2.39704 |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | -2.39468 |
| SH3D19 | SH3 domain containing 19 | -2.3919 |
| SPC25 | SPC25, NDC80 kinetochore complex component | -2.37282 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -2.35564 |
| STMN1 | stathmin 1 | -2.35329 |
| SOCS5 | suppressor of cytokine signaling 5 | -2.35164 |
| GRB2 | growth factor receptor-bound protein 2 | -2.33215 |
| MRPS17 | mitochondrial ribosomal protein S17 | -2.3257 |
| PBK | PDZ binding kinase | -2.32423 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | -2.32141 |
| RPS5 | ribosomal protein S5 | -2.30854 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -2.29334 |
| PGK1 | phosphoglycerate kinase 1 | -2.28937 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | -2.28637 |
| BLMH | bleomycin hydrolase | -2.28573 |
| HSPE1 | heat shock 10kDa protein 1 | -2.28269 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -2.27739 |
| NEK2 | NIMA-related kinase 2 | -2.26333 |
| ARHGAP11A | Rho GTPase activating protein 11A | -2.25784 |
| PPA1 | pyrophosphatase (inorganic) 1 | -2.24375 |
| OSGEPL1 | O-sialoglycoprotein endopeptidase-like 1 | -2.23853 |
| RNF115 | ring finger protein 115 | -2.23808 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | -2.23648 |
| CALCRL | calcitonin receptor-like | -2.22625 |
| TMEM168 | transmembrane protein 168 | -2.22004 |
| FAM200C | family with sequence similarity 200 member C | -2.21854 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | -2.21849 |
| GMNN | geminin, DNA replication inhibitor | -2.2003 |
| HOXA4 | homeobox A4 | -2.19615 |
| CENPI | centromere protein I | -2.19112 |
| HNRNPF | heterogeneous nuclear ribonucleoprotein F | -2.18587 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -2.183 |
| KIFBP | kinesin family binding protein | -2.17298 |
| DARS2 | aspartyl-tRNA synthetase 2, mitochondrial | -2.16803 |
| TRIM9 | tripartite motif containing 9 | -2.16793 |
| PSMA2 | proteasome (prosome, macropain) subunit, alpha type, 2 | -2.16293 |
| ADI1 | acireductone dioxygenase 1 | -2.16285 |
| KIAA0586 | KIAA0586 | -2.15989 |
| ZNF184 | zinc finger protein 184 | -2.14434 |
| ELOVL6 | ELOVL fatty acid elongase 6 | -2.14309 |
| LBR | lamin B receptor | -2.14269 |
| WDR76 | WD repeat domain 76 | -2.13514 |
| LAMTOR3 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 | -2.13498 |
| FPGS | folylpolyglutamate synthase | -2.13062 |
| H2AC4 | H2A clustered histone 4 | -2.12732 |
| CDCA3 | cell division cycle associated 3 | -2.12356 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 | -2.11191 |
| H2BC4 | H2B clustered histone 4 | -2.11029 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | -2.10996 |
| SAP30BP | SAP30 binding protein | -2.10576 |
| HTD2 | hydroxyacyl-thioester dehydratase type 2 | -2.0998 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -2.09436 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -2.09353 |
| PRC1 | protein regulator of cytokinesis 1 | -2.09256 |
| ILF2 | interleukin enhancer binding factor 2 | -2.08834 |
| PEX2 | peroxisomal biogenesis factor 2 | -2.08493 |
| PIMREG | PICALM interacting mitotic regulator | -2.08473 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -2.08394 |
| HDAC2 | histone deacetylase 2 | -2.08285 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -2.0765 |
| CDK1 | cyclin-dependent kinase 1 | -2.07179 |
| TUBA1B | tubulin, alpha 1b | -2.07064 |
| FASTKD3 | FAST kinase domains 3 | -2.0631 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -2.05754 |
| COXFA4 | cytochrome c oxidase associated subunit FA4 | -2.05721 |
| TTC33 | tetratricopeptide repeat domain 33 | -2.05454 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | -2.04221 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -2.0374 |
| H2AC25 | H2A clustered histone 25 | -2.03694 |
| GJD3 | gap junction protein, delta 3, 31.9kDa | -2.03495 |
| MRPL58 | mitochondrial ribosomal protein L58 | -2.03318 |
| GPR162 | G protein-coupled receptor 162 | -2.03011 |
| H1-2 | H1.2 linker histone, cluster member | -2.02435 |
| TMA16 | translation machinery associated 16 homolog (S. cerevisiae) | -2.0211 |
| PTK2 | protein tyrosine kinase 2 | -2.01104 |
| CCNF | cyclin F | -2.00976 |
| AIFM1 | apoptosis-inducing factor, mitochondrion-associated, 1 | -2.00909 |
| NUS1 | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) | -2.00403 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | -2.00065 |
