CRCGN016_MCF10A.TP53.M_24H:A23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description melphalan 32.65 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

136 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:A23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 6.4972
SPAG4 sperm associated antigen 4 5.29435
STIMATE STIM activating enhancer 5.1307
TCEA2 transcription elongation factor A (SII), 2 5.11075
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.25625
AGR2 anterior gradient 2 4.18725
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.88705
CNRIP1 cannabinoid receptor interacting protein 1 3.6959
CCL2 chemokine (C-C motif) ligand 2 3.5322
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.45075
ICAM3 intercellular adhesion molecule 3 3.16385
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 3.12705
ACAA1 acetyl-CoA acyltransferase 1 3.06667
NGRN neugrin, neurite outgrowth associated 3.05725
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 3.0047
CDC45 cell division cycle 45 2.99635
THAP7 THAP domain containing 7 2.8918
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.8413
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 2.76592
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.7207
CYB5R1 cytochrome b5 reductase 1 2.6632
TICAM1 toll-like receptor adaptor molecule 1 2.6496
MINDY1 MINDY lysine 48 deubiquitinase 1 2.60375
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.59385
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.58837
INTS3 integrator complex subunit 3 2.5802
RIGI RNA sensor RIG-I 2.56655
DNMT1 DNA (cytosine-5-)-methyltransferase 1 2.50605
LOC122526780 uncharacterized LOC122526780 2.4897
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.47146
PDLIM1 PDZ and LIM domain 1 2.4713
PRR15L proline rich 15-like 2.44005
STXBP1 syntaxin binding protein 1 2.41965
PWP1 PWP1 homolog (S. cerevisiae) 2.3741
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 2.34325
UFD1 ubiquitin recognition factor in ER associated degradation 1 2.31685
STAP2 signal transducing adaptor family member 2 2.31405
CENPM centromere protein M 2.2963
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.2899
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.28765
CCNE1 cyclin E1 2.27415
BRCA1 breast cancer 1, early onset 2.25787
EPHX3 epoxide hydrolase 3 2.2535
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.24285
PCDHB11 protocadherin beta 11 2.2166
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.2026
CRCT1 cysteine-rich C-terminal 1 2.2011
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.2
NOP10 NOP10 ribonucleoprotein 2.18965
INPP1 inositol polyphosphate-1-phosphatase 2.18785
IFI35 interferon-induced protein 35 2.17625
TMBIM1 transmembrane BAX inhibitor motif containing 1 2.16945
MED15 mediator complex subunit 15 2.16525
DGCR6L DiGeorge syndrome critical region gene 6-like 2.1627
SPRR1B small proline-rich protein 1B 2.1619
ISG15 ISG15 ubiquitin-like modifier 2.15315
RIC8A RIC8 guanine nucleotide exchange factor A 2.12725
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.07725
IL32 interleukin 32 2.05695
MRPL17 mitochondrial ribosomal protein L17 2.05435
PARP12 poly (ADP-ribose) polymerase family, member 12 2.0503
SPRR3 small proline-rich protein 3 2.04565
ACLY ATP citrate lyase 2.04478
CCDC69 coiled-coil domain containing 69 2.0348
USP18 ubiquitin specific peptidase 18 2.0329
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae) 2.0322
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa 2.0222
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 2.02095
CASZ1 castor zinc finger 1 2.01515
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 2.01175
RHCG Rh family, C glycoprotein 2.007
ASL argininosuccinate lyase 2.00175
LRP10 low density lipoprotein receptor-related protein 10 2.00145

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -6.85015
UBE2C ubiquitin-conjugating enzyme E2C -5.6616
PSRC1 proline/serine-rich coiled-coil 1 -5.53035
KIF20A kinesin family member 20A -5.4473
CCNB2 cyclin B2 -4.8862
TOP2A topoisomerase (DNA) II alpha 170kDa -3.9951
PLK1 polo-like kinase 1 -3.9714
NLRP4 NLR family, pyrin domain containing 4 -3.88855
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.2
DEPDC1 DEP domain containing 1 -3.1565
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.08433
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.9754
CCNB1 cyclin B1 -2.9616
KIF14 kinesin family member 14 -2.8949
H2BC12 H2B clustered histone 12 -2.78467
PRR7 proline rich 7 (synaptic) -2.70625
ZSCAN9 zinc finger and SCAN domain containing 9 -2.6931
RNF167 ring finger protein 167 -2.63495
NEK2 NIMA-related kinase 2 -2.60448
LBR lamin B receptor -2.6018
MTERF3 mitochondrial transcription termination factor 3 -2.587
PSME3IP1 proteasome activator subunit 3 interacting protein 1 -2.5818
NCAPD2 non-SMC condensin I complex, subunit D2 -2.5398
H2AC6 H2A clustered histone 6 -2.4501
TCERG1 transcription elongation regulator 1 -2.44405
HSPA1A heat shock 70kDa protein 1A -2.44145
EBAG9 estrogen receptor binding site associated, antigen, 9 -2.43383
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -2.40105
CDHR1 cadherin-related family member 1 -2.38665
GPSM2 G-protein signaling modulator 2 -2.32538
TEX10 testis expressed 10 -2.2985
NIPSNAP2 nipsnap homolog 2 -2.2884
MNDA myeloid cell nuclear differentiation antigen -2.28325
AURKA aurora kinase A -2.27068
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.26765
CDX2 caudal type homeobox 2 -2.26605
BIRC5 baculoviral IAP repeat containing 5 -2.25928
KIF11 kinesin family member 11 -2.2545
RBM12B RNA binding motif protein 12B -2.23
CHD1 chromodomain helicase DNA binding protein 1 -2.20545
INTS8 integrator complex subunit 8 -2.1956
CLCC1 chloride channel CLIC-like 1 -2.1704
GLYAT glycine-N-acyltransferase -2.16849
SAYSD1 SAYSVFN motif domain containing 1 -2.16815
CLIC4 chloride intracellular channel 4 -2.16183
SLC35F2 solute carrier family 35, member F2 -2.149
CENPA centromere protein A -2.12095
MRPL37 mitochondrial ribosomal protein L37 -2.11065
RPGRIP1L RPGRIP1-like -2.1037
SNAI2 snail family zinc finger 2 -2.102
ENY2 enhancer of yellow 2 homolog (Drosophila) -2.10125
TBC1D15 TBC1 domain family, member 15 -2.0958
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.09015
SSBP3 single stranded DNA binding protein 3 -2.0833
ZFC3H1 zinc finger, C3H1-type containing -2.0765
FKTN fukutin -2.0736
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) -2.0718
CLASRP CLK4-associating serine/arginine rich protein -2.05405
KRT14 keratin 14, type I -2.0376
CENPE centromere protein E, 312kDa -2.03715
RBL2 retinoblastoma-like 2 -2.0371
MMP13 matrix metallopeptidase 13 -2.02975
WRN Werner syndrome, RecQ helicase-like -2.02745