CRCGN016_MCF10A.TP53.M_24H:B11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chrysene 31.07 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

120 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:B11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPL39L ribosomal protein L39-like 5.03795
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.02225
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.8424
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.8273
FGFR4 fibroblast growth factor receptor 4 4.2081
ACLY ATP citrate lyase 3.79862
ACAA1 acetyl-CoA acyltransferase 1 3.61503
KIF5C kinesin family member 5C 3.51618
EPHB2 EPH receptor B2 3.23588
TOR4A torsin family 4, member A 3.1769
TLCD3A TLC domain containing 3A 3.1139
TBXA2R thromboxane A2 receptor 2.98076
CLIP2 CAP-GLY domain containing linker protein 2 2.9212
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2.6647
ZNF197 zinc finger protein 197 2.6315
RNF19B ring finger protein 19B 2.5779
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.55885
UNC13D unc-13 homolog D (C. elegans) 2.44245
MTMR11 myotubularin related protein 11 2.4416
PRSS21 protease, serine, 21 (testisin) 2.42635
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 2.41817
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.41167
IL32 interleukin 32 2.3704
WFDC1 WAP four-disulfide core domain 1 2.36035
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.35865
PEX6 peroxisomal biogenesis factor 6 2.3582
STRN4 striatin, calmodulin binding protein 4 2.34535
MEST mesoderm specific transcript 2.34325
RAMP3 receptor (G protein-coupled) activity modifying protein 3 2.32465
RFXANK regulatory factor X-associated ankyrin-containing protein 2.314
PGPEP1 pyroglutamyl-peptidase I 2.30105
ATAD3A ATPase family, AAA domain containing 3A 2.29065
BCL3 B-cell CLL/lymphoma 3 2.2839
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 2.27305
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.2452
CNTNAP1 contactin associated protein 1 2.2168
NELFB negative elongation factor complex member B 2.20695
DTX2 deltex 2, E3 ubiquitin ligase 2.20525
SH3BP1 SH3-domain binding protein 1 2.18745
MRGBP MRG/MORF4L binding protein 2.16175
ATP13A2 ATPase type 13A2 2.146
TBC1D13 TBC1 domain family, member 13 2.1451
IFT88 intraflagellar transport 88 2.13495
MARCKSL1 MARCKS-like 1 2.1088
PRAME preferentially expressed antigen in melanoma 2.1076
BIK BCL2-interacting killer (apoptosis-inducing) 2.0967
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.09597
DPF3 D4, zinc and double PHD fingers, family 3 2.0842
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 2.07098
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.04845
SRRD SRR1 domain containing 2.04225
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.0417
SIPA1 signal-induced proliferation-associated 1 2.0347
GLI1 GLI family zinc finger 1 2.02765
TRAF3 TNF receptor-associated factor 3 2.016
MAP3K6 mitogen-activated protein kinase kinase kinase 6 2.0061

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -5.54095
NLRP4 NLR family, pyrin domain containing 4 -5.22195
PGAM4 phosphoglycerate mutase family member 4 -5.14615
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.98735
HMG20B high mobility group 20B -4.66668
DIPK1A divergent protein kinase domain 1A -4.61277
TUBB6 tubulin, beta 6 class V -4.3598
ATF5 activating transcription factor 5 -3.67718
CAPN2 calpain 2, (m/II) large subunit -3.63542
RPA3 replication protein A3, 14kDa -3.40195
TEX10 testis expressed 10 -3.23245
TIMP1 TIMP metallopeptidase inhibitor 1 -2.93335
KRT14 keratin 14, type I -2.91145
HSPA1A heat shock 70kDa protein 1A -2.8717
THAP11 THAP domain containing 11 -2.84945
THNSL1 threonine synthase-like 1 (S. cerevisiae) -2.802
BBS10 Bardet-Biedl syndrome 10 -2.7451
ANXA2 annexin A2 -2.64772
MDH1 malate dehydrogenase 1, NAD (soluble) -2.61275
LAPTM4A lysosomal protein transmembrane 4 alpha -2.51295
MRPL18 mitochondrial ribosomal protein L18 -2.51055
MSN moesin -2.49935
TM9SF2 transmembrane 9 superfamily member 2 -2.47035
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -2.4651
COX15 cytochrome c oxidase assembly homolog 15 (yeast) -2.4563
GHITM growth hormone inducible transmembrane protein -2.44147
UNC50 unc-50 homolog (C. elegans) -2.40015
FAM200C family with sequence similarity 200 member C -2.3875
MAP2K1 mitogen-activated protein kinase kinase 1 -2.3392
RPS27A ribosomal protein S27a -2.33105
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.30735
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.25535
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -2.2496
PIGF phosphatidylinositol glycan anchor biosynthesis, class F -2.24685
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.24665
PGK1 phosphoglycerate kinase 1 -2.2294
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -2.22205
CPEB3 cytoplasmic polyadenylation element binding protein 3 -2.2202
USO1 USO1 vesicle transport factor -2.2146
MOCS2 molybdenum cofactor synthesis 2 -2.1988
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.18692
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 -2.15325
F9 coagulation factor IX -2.14805
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -2.1412
PUS3 pseudouridylate synthase 3 -2.1277
PIH1D1 PIH1 domain containing 1 -2.11075
HADH hydroxyacyl-CoA dehydrogenase -2.10768
FBXO21 F-box protein 21 -2.10663
RPP30 ribonuclease P/MRP 30kDa subunit -2.1009
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.0974
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.0913
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -2.08785
BLTP3B bridge-like lipid transfer protein family member 3B -2.0842
TMBIM6 transmembrane BAX inhibitor motif containing 6 -2.0784
UBE2W ubiquitin-conjugating enzyme E2W (putative) -2.076
MARCHF5 membrane associated ring-CH-type finger 5 -2.0714
SOX3 SRY (sex determining region Y)-box 3 -2.06765
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.0572
CTSO cathepsin O -2.04655
VAMP7 vesicle-associated membrane protein 7 -2.03795
CCL22 chemokine (C-C motif) ligand 22 -2.0356
GOLT1A golgi transport 1A -2.02975
BANP BTG3 associated nuclear protein -2.01735
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 -2.00828