CRCGN016_MCF10A.TP53.M_24H:B22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorambucil 99.58 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

562 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:B22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 10.0
TICAM1 toll-like receptor adaptor molecule 1 7.749
TP53BP2 tumor protein p53 binding protein 2 6.44442
LRP10 low density lipoprotein receptor-related protein 10 5.36457
MINDY1 MINDY lysine 48 deubiquitinase 1 5.30732
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 5.22344
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.84112
HMOX1 heme oxygenase 1 4.54099
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.53915
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.47292
CHIC2 cysteine-rich hydrophobic domain 2 4.42406
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.31773
GLRX glutaredoxin (thioltransferase) 4.28892
LAGE3 L antigen family, member 3 4.21055
CNRIP1 cannabinoid receptor interacting protein 1 4.11537
STAP2 signal transducing adaptor family member 2 4.08381
ALAS1 5'-aminolevulinate synthase 1 4.06364
TNIP1 TNFAIP3 interacting protein 1 3.98165
FHL2 four and a half LIM domains 2 3.78511
OXSR1 oxidative stress responsive 1 3.74385
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 3.73802
MVP major vault protein 3.73735
SKIC2 SKI2 subunit of superkiller complex 3.73591
VAT1 vesicle amine transport 1 3.73487
MX1 MX dynamin-like GTPase 1 3.70545
STXBP1 syntaxin binding protein 1 3.69195
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 3.68626
SAMD9 sterile alpha motif domain containing 9 3.62981
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 3.6142
LSR lipolysis stimulated lipoprotein receptor 3.59789
DUSP14 dual specificity phosphatase 14 3.58248
PDLIM1 PDZ and LIM domain 1 3.47824
CASP7 caspase 7, apoptosis-related cysteine peptidase 3.46116
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 3.40745
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 3.39655
ABHD4 abhydrolase domain containing 4 3.37667
ISG15 ISG15 ubiquitin-like modifier 3.37324
TIMP2 TIMP metallopeptidase inhibitor 2 3.36687
CDPF1 cysteine-rich, DPF motif domain containing 1 3.36141
IRF9 interferon regulatory factor 9 3.32854
SLC35B1 solute carrier family 35, member B1 3.3185
IRF7 interferon regulatory factor 7 3.26842
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 3.23404
TUFT1 tuftelin 1 3.21618
RSAD2 radical S-adenosyl methionine domain containing 2 3.19702
WIF1 WNT inhibitory factor 1 3.16501
CLDN4 claudin 4 3.1287
CEMIP2 cell migration inducing hyaluronidase 2 3.10404
TMEM50A transmembrane protein 50A 3.08527
CCND3 cyclin D3 3.03789
RAB8A RAB8A, member RAS oncogene family 3.03542
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 3.02869
ATF3 activating transcription factor 3 3.0264
RIGI RNA sensor RIG-I 2.99353
AGR2 anterior gradient 2 2.93626
IFI27 interferon, alpha-inducible protein 27 2.93129
SLC44A4 solute carrier family 44, member 4 2.91984
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.91026
TPD52L2 tumor protein D52-like 2 2.9072
DDA1 DET1 and DDB1 associated 1 2.90492
IFI35 interferon-induced protein 35 2.88572
HLA-G major histocompatibility complex, class I, G 2.87675
HLA-B major histocompatibility complex, class I, B 2.85998
CANT1 calcium activated nucleotidase 1 2.83237
PARP12 poly (ADP-ribose) polymerase family, member 12 2.83184
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.82415
SLC10A3 solute carrier family 10, member 3 2.82307
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.81869
IFI6 interferon, alpha-inducible protein 6 2.80738
TUBB6 tubulin, beta 6 class V 2.79311
TMBIM1 transmembrane BAX inhibitor motif containing 1 2.7923
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.76143
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 2.74404
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.73548
MCOLN1 mucolipin 1 2.7336
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 2.72148
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.71724
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.70825
ZMPSTE24 zinc metallopeptidase STE24 2.69698
EDN1 endothelin 1 2.69412
CCNE2 cyclin E2 2.67199
GMEB2 glucocorticoid modulatory element binding protein 2 2.66459
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.66309
PERP PERP, TP53 apoptosis effector 2.66138
KIF5C kinesin family member 5C 2.65739
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 2.65712
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.65549
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 2.65516
MISP mitotic spindle positioning 2.65098
HLA-F major histocompatibility complex, class I, F 2.62678
KRT16 keratin 16, type I 2.62477
CLDN7 claudin 7 2.62089
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 2.61917
FAM50A family with sequence similarity 50, member A 2.6
PMP22 peripheral myelin protein 22 2.56983
MAPK3 mitogen-activated protein kinase 3 2.56745
SOX4 SRY (sex determining region Y)-box 4 2.56141
OASL 2'-5'-oligoadenylate synthetase-like 2.55742
PRSS22 protease, serine, 22 2.53108
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.52198
ITPRID2 ITPR interacting domain containing 2 2.51583
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.51579
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.51558
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.51532
UBE2A ubiquitin-conjugating enzyme E2A 2.51531
JOSD1 Josephin domain containing 1 2.51284
GDI1 GDP dissociation inhibitor 1 2.50079
MTCH1 mitochondrial carrier 1 2.48926
IGFBP3 insulin-like growth factor binding protein 3 2.48448
NBEAL2 neurobeachin-like 2 2.48381
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 2.47461
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.46869
TOR1AIP2 torsin A interacting protein 2 2.46191
IRF6 interferon regulatory factor 6 2.45297
SPRR2B small proline-rich protein 2B 2.45006
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 2.4495
RAP1GAP RAP1 GTPase activating protein 2.43693
CORO1A coronin, actin binding protein, 1A 2.42909
CDK7 cyclin-dependent kinase 7 2.41777
PRR13 proline rich 13 2.41691
HAT1 histone acetyltransferase 1 2.40718
NOP10 NOP10 ribonucleoprotein 2.40478
MUC13 mucin 13, cell surface associated 2.40451
INPPL1 inositol polyphosphate phosphatase-like 1 2.4014
CTSV cathepsin V 2.39871
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.39556
TCEA2 transcription elongation factor A (SII), 2 2.38995
ANXA11 annexin A11 2.38824
MAPK7 mitogen-activated protein kinase 7 2.3834
KLF4 Kruppel-like factor 4 (gut) 2.37675
BIN3 bridging integrator 3 2.37179
SIPA1 signal-induced proliferation-associated 1 2.36922
LOC127933115 uncharacterized LOC127933115 2.35787
CXCL2 chemokine (C-X-C motif) ligand 2 2.35063
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 2.34965
JUND jun D proto-oncogene 2.34812
SNF8 SNF8, ESCRT-II complex subunit 2.34466
MFAP2 microfibrillar-associated protein 2 2.3346
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.33419
HSPB11 heat shock protein family B (small), member 11 2.32953
HMGXB4 HMG box domain containing 4 2.31263
MICB MHC class I polypeptide-related sequence B 2.30894
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 2.29882
RGS2 regulator of G-protein signaling 2 2.29724
ISG20 interferon stimulated exonuclease gene 20kDa 2.29234
POLR1A polymerase (RNA) I polypeptide A, 194kDa 2.28137
TRIM21 tripartite motif containing 21 2.27908
PI3 peptidase inhibitor 3, skin-derived 2.27367
IFITM1 interferon induced transmembrane protein 1 2.26268
ZFP36 ZFP36 ring finger protein 2.25907
KIF13B kinesin family member 13B 2.25242
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.25128
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 2.24272
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.23986
EPHA2 EPH receptor A2 2.23331
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.2333
NDEL1 nudE neurodevelopment protein 1-like 1 2.23314
MEA1 male-enhanced antigen 1 2.23173
CXCL8 chemokine (C-X-C motif) ligand 8 2.23071
TBC1D10C TBC1 domain family, member 10C 2.22903
HLA-C major histocompatibility complex, class I, C 2.2227
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 2.21822
NDRG4 NDRG family member 4 2.21756
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 2.21392
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 2.20821
RAP1B RAP1B, member of RAS oncogene family 2.1965
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 2.18883
LGALS9C lectin, galactoside-binding, soluble, 9C 2.18709
IL22RA1 interleukin 22 receptor, alpha 1 2.17808
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.178
TMEM41B transmembrane protein 41B 2.17258
BMP4 bone morphogenetic protein 4 2.16121
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 2.16061
IL36G interleukin 36, gamma 2.15431
GID8 GID complex subunit 8 2.15145
IL32 interleukin 32 2.14745
MAP7D1 MAP7 domain containing 1 2.14524
MYH9 myosin, heavy chain 9, non-muscle 2.14199
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 2.13524
TM9SF2 transmembrane 9 superfamily member 2 2.13441
ARMCX3 armadillo repeat containing, X-linked 3 2.13271
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.13167
KRT8 keratin 8, type II 2.13111
UPP1 uridine phosphorylase 1 2.12655
CYTH2 cytohesin 2 2.12548
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 2.12366
CYB5R1 cytochrome b5 reductase 1 2.12027
ICAM1 intercellular adhesion molecule 1 2.11789
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 2.1105
OCLN occludin 2.10669
PLAUR plasminogen activator, urokinase receptor 2.10475
TMEM59 transmembrane protein 59 2.10283
ARHGAP17 Rho GTPase activating protein 17 2.09724
MUC1 mucin 1, cell surface associated 2.09289
IER3 immediate early response 3 2.08956
NECAP2 NECAP endocytosis associated 2 2.08851
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 2.08598
XAF1 XIAP associated factor 1 2.08176
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.0814
ATG2A autophagy related 2A 2.07704
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 2.07333
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 2.06962
ADRB2 adrenoceptor beta 2, surface 2.06478
F3 coagulation factor III (thromboplastin, tissue factor) 2.05807
BCL7C B-cell CLL/lymphoma 7C 2.05708
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 2.05007
FMR1 fragile X mental retardation 1 2.04896
RTN3 reticulon 3 2.04753
GMIP GEM interacting protein 2.04462
IL1A interleukin 1, alpha 2.03755
BMP2 bone morphogenetic protein 2 2.03447
STX4 syntaxin 4 2.03439
MAP7 microtubule-associated protein 7 2.03121
ADRM1 adhesion regulating molecule 1 2.02711
IFI44 interferon-induced protein 44 2.02517
PLK3 polo-like kinase 3 2.00721
CRABP2 cellular retinoic acid binding protein 2 2.00601
SUSD6 sushi domain containing 6 2.00487
OPTN optineurin 2.00111
ZC3H12A zinc finger CCCH-type containing 12A 2.00077

decreased expression

Symbol Name Standardized Value
KIF20A kinesin family member 20A -8.48126
PSRC1 proline/serine-rich coiled-coil 1 -7.96678
NLRP4 NLR family, pyrin domain containing 4 -7.87983
CCNB2 cyclin B2 -7.72171
ANKRD10 ankyrin repeat domain 10 -7.1476
UBE2C ubiquitin-conjugating enzyme E2C -7.1421
TSEN2 TSEN2 tRNA splicing endonuclease subunit -5.7
CDC20 cell division cycle 20 -5.68706
TOP2A topoisomerase (DNA) II alpha 170kDa -5.36268
HMMR hyaluronan-mediated motility receptor (RHAMM) -4.92265
PLK1 polo-like kinase 1 -4.8433
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.82903
ASCC3 activating signal cointegrator 1 complex subunit 3 -4.8281
PCCB propionyl CoA carboxylase, beta polypeptide -4.59375
BIRC5 baculoviral IAP repeat containing 5 -4.54277
AURKA aurora kinase A -4.45562
MSRA methionine sulfoxide reductase A -4.45477
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) -4.37446
CCNB1 cyclin B1 -4.36163
CENPA centromere protein A -4.15779
GALE UDP-galactose-4-epimerase -4.06976
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -4.06524
DEPDC1 DEP domain containing 1 -4.00168
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.9399
C1QBP complement component 1, q subcomponent binding protein -3.90585
HOXA5 homeobox A5 -3.87683
DNM1L dynamin 1-like -3.86168
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.81544
BLMH bleomycin hydrolase -3.77641
DET1 de-etiolated homolog 1 (Arabidopsis) -3.75529
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.74683
RXYLT1 ribitol xylosyltransferase 1 -3.74665
HEATR1 HEAT repeat containing 1 -3.6652
CETN3 centrin, EF-hand protein, 3 -3.65026
DDIT4 DNA-damage-inducible transcript 4 -3.61669
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -3.61265
RUVBL1 RuvB-like AAA ATPase 1 -3.60329
PARPBP PARP1 binding protein -3.59326
INTS14 integrator complex subunit 14 -3.54934
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -3.54505
LBR lamin B receptor -3.51159
KIAA0586 KIAA0586 -3.47162
PGM1 phosphoglucomutase 1 -3.46766
CCNA2 cyclin A2 -3.37673
YME1L1 YME1-like 1 ATPase -3.37579
MYC v-myc avian myelocytomatosis viral oncogene homolog -3.37047
KIF4A kinesin family member 4A -3.36808
KIF18A kinesin family member 18A -3.33962
TCTN1 tectonic family member 1 -3.29781
PHKB phosphorylase kinase, beta -3.29451
COG2 component of oligomeric golgi complex 2 -3.29277
CDCA3 cell division cycle associated 3 -3.27167
EBNA1BP2 EBNA1 binding protein 2 -3.25753
NEK2 NIMA-related kinase 2 -3.25508
FAM216A family with sequence similarity 216, member A -3.24168
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -3.21933
CDC25C cell division cycle 25C -3.18396
KIF23 kinesin family member 23 -3.1733
NCAPD2 non-SMC condensin I complex, subunit D2 -3.17226
TXNRD3 thioredoxin reductase 3 -3.16887
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -3.11319
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 -3.10988
KIF14 kinesin family member 14 -3.09117
NOP16 NOP16 nucleolar protein -3.07688
CEP83 centrosomal protein 83kDa -3.05349
TRAP1 TNF receptor-associated protein 1 -3.05053
MEMO1 mediator of cell motility 1 -3.03901
CDKN3 cyclin-dependent kinase inhibitor 3 -3.02018
PIMREG PICALM interacting mitotic regulator -3.01708
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) -3.01298
TFB1M transcription factor B1, mitochondrial -3.01253
ZNF280D zinc finger protein 280D -3.00495
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.00337
RSU1 Ras suppressor protein 1 -2.9878
COPZ1 coatomer protein complex, subunit zeta 1 -2.98339
DCTD dCMP deaminase -2.9768
BZW2 basic leucine zipper and W2 domains 2 -2.97416
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.97164
RHOT1 ras homolog family member T1 -2.95329
PRR7 proline rich 7 (synaptic) -2.94632
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit -2.94457
CKAP2 cytoskeleton associated protein 2 -2.93375
CYCS cytochrome c, somatic -2.92587
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.92432
MTIF2 mitochondrial translational initiation factor 2 -2.92386
SLC35F2 solute carrier family 35, member F2 -2.91735
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.89162
NHP2 NHP2 ribonucleoprotein -2.88486
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.86319
OXSM 3-oxoacyl-ACP synthase, mitochondrial -2.84574
MRPL3 mitochondrial ribosomal protein L3 -2.84573
COQ3 coenzyme Q3 methyltransferase -2.84402
GPHN gephyrin -2.8274
GCLC glutamate-cysteine ligase, catalytic subunit -2.8124
ZSCAN5A zinc finger and SCAN domain containing 5A -2.81073
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.8064
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -2.80423
GFUS GDP-L-fucose synthase -2.79832
DPH5 diphthamide biosynthesis 5 -2.79432
PUS1 pseudouridylate synthase 1 -2.78684
TSC22D3 TSC22 domain family, member 3 -2.78527
INTS13 integrator complex subunit 13 -2.76907
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.76692
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 -2.76489
MKKS McKusick-Kaufman syndrome -2.75693
ZNF354A zinc finger protein 354A -2.7563
DPH2 DPH2 homolog (S. cerevisiae) -2.75416
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -2.75307
CADPS2 Ca++-dependent secretion activator 2 -2.71854
WDR12 WD repeat domain 12 -2.68993
NFYB nuclear transcription factor Y, beta -2.68651
AAAS achalasia, adrenocortical insufficiency, alacrimia -2.67901
ENTR1 endosome associated trafficking regulator 1 -2.66198
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -2.65053
GCSH glycine cleavage system protein H (aminomethyl carrier) -2.63879
NUP37 nucleoporin 37kDa -2.63448
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.62718
KIFBP kinesin family binding protein -2.6124
GPSM2 G-protein signaling modulator 2 -2.60464
SETDB1 SET domain, bifurcated 1 -2.59063
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -2.57974
ZNF32 zinc finger protein 32 -2.5752
TRIM27 tripartite motif containing 27 -2.57455
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) -2.57321
DIPK1A divergent protein kinase domain 1A -2.57096
CENPF centromere protein F, 350/400kDa -2.56561
MPHOSPH6 M-phase phosphoprotein 6 -2.5649
CCL13 chemokine (C-C motif) ligand 13 -2.56331
METTL8 methyltransferase like 8 -2.55079
PRC1 protein regulator of cytokinesis 1 -2.54873
EPHB2 EPH receptor B2 -2.54869
RACGAP1 Rac GTPase activating protein 1 -2.54539
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -2.53839
MPHOSPH9 M-phase phosphoprotein 9 -2.53441
ALG3 ALG3, alpha-1,3- mannosyltransferase -2.51223
RNF146 ring finger protein 146 -2.50662
KIF15 kinesin family member 15 -2.50074
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.49361
PPA2 pyrophosphatase (inorganic) 2 -2.48588
LDAH lipid droplet associated hydrolase -2.47953
HMG20A high mobility group 20A -2.47442
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase -2.47237
TSKU tsukushi, small leucine rich proteoglycan -2.46462
CDC23 cell division cycle 23 -2.4535
UNC50 unc-50 homolog (C. elegans) -2.45274
VWA8 von Willebrand factor A domain containing 8 -2.44776
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.44724
ARHGAP11A Rho GTPase activating protein 11A -2.44656
CAMKMT calmodulin-lysine N-methyltransferase -2.44613
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -2.44488
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -2.44465
HEATR3 HEAT repeat containing 3 -2.44355
ETFA electron-transfer-flavoprotein, alpha polypeptide -2.44324
NIPSNAP2 nipsnap homolog 2 -2.4429
RPGRIP1L RPGRIP1-like -2.42277
REV1 REV1, polymerase (DNA directed) -2.42276
SGPP1 sphingosine-1-phosphate phosphatase 1 -2.42255
ECHDC3 enoyl CoA hydratase domain containing 3 -2.42164
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) -2.41785
ANAPC1 anaphase promoting complex subunit 1 -2.41354
DNM1 dynamin 1 -2.40856
ACOX2 acyl-CoA oxidase 2, branched chain -2.40854
POLR3B polymerase (RNA) III (DNA directed) polypeptide B -2.40697
MRPL19 mitochondrial ribosomal protein L19 -2.4054
DPP8 dipeptidyl-peptidase 8 -2.39716
WASHC3 WASH complex subunit 3 -2.39237
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B -2.38522
CHRDL1 chordin-like 1 -2.38212
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) -2.38122
COASY CoA synthase -2.38029
SPA17 sperm autoantigenic protein 17 -2.37925
LIAS lipoic acid synthetase -2.37726
EIF2D eukaryotic translation initiation factor 2D -2.37675
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -2.37651
ACSM3 acyl-CoA synthetase medium-chain family member 3 -2.3693
HOXA4 homeobox A4 -2.36846
TMT1A thiol methyltransferase 1A -2.36788
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial -2.3653
TUBGCP5 tubulin, gamma complex associated protein 5 -2.36437
PSPC1 paraspeckle component 1 -2.35923
TTK TTK protein kinase -2.3574
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 -2.35123
CGREF1 cell growth regulator with EF-hand domain 1 -2.34951
BACE2 beta-site APP-cleaving enzyme 2 -2.34682
DHODH dihydroorotate dehydrogenase (quinone) -2.34493
ZZZ3 zinc finger, ZZ-type containing 3 -2.33799
ATP5F1C ATP synthase F1 subunit gamma -2.33487
SCARB1 scavenger receptor class B, member 1 -2.33249
GIN1 gypsy retrotransposon integrase 1 -2.32965
MRPL58 mitochondrial ribosomal protein L58 -2.3241
GPD1L glycerol-3-phosphate dehydrogenase 1-like -2.32245
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -2.30985
ACOD1 aconitate decarboxylase 1 -2.3076
PIGN phosphatidylinositol glycan anchor biosynthesis, class N -2.30431
SUMF2 sulfatase modifying factor 2 -2.30202
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.29988
TROAP trophinin associated protein -2.2944
PYCR1 pyrroline-5-carboxylate reductase 1 -2.29389
CDCA8 cell division cycle associated 8 -2.29189
MLYCD malonyl-CoA decarboxylase -2.28423
CD320 CD320 molecule -2.28325
ATP5PB ATP synthase peripheral stalk-membrane subunit b -2.28262
ZMYM3 zinc finger, MYM-type 3 -2.28122
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa -2.27849
TRAPPC12 trafficking protein particle complex 12 -2.27838
CDC16 cell division cycle 16 -2.27614
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.27462
MRPS18B mitochondrial ribosomal protein S18B -2.27281
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.27211
SELENOF selenoprotein F -2.27184
G6PC3 glucose 6 phosphatase, catalytic, 3 -2.26256
PUM2 pumilio RNA-binding family member 2 -2.26013
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -2.25765
PRMT3 protein arginine methyltransferase 3 -2.25488
HSF2BP heat shock transcription factor 2 binding protein -2.25254
MECR mitochondrial trans-2-enoyl-CoA reductase -2.24951
RACK1 receptor for activated C kinase 1 -2.24906
CHD9 chromodomain helicase DNA binding protein 9 -2.24428
CEP63 centrosomal protein 63kDa -2.2424
HADH hydroxyacyl-CoA dehydrogenase -2.24136
LRPPRC leucine-rich pentatricopeptide repeat containing -2.23801
RIOX2 ribosomal oxygenase 2 -2.23514
NUBPL nucleotide binding protein-like -2.2315
PARK7 parkinson protein 7 -2.22772
TMA16 translation machinery associated 16 homolog (S. cerevisiae) -2.22429
COMMD10 COMM domain containing 10 -2.2175
SPDL1 spindle apparatus coiled-coil protein 1 -2.21477
RABEPK Rab9 effector protein with kelch motifs -2.20628
BCHE butyrylcholinesterase -2.2055
PXMP4 peroxisomal membrane protein 4, 24kDa -2.20135
TKT transketolase -2.19914
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 -2.19217
RPS5 ribosomal protein S5 -2.19212
CEP55 centrosomal protein 55kDa -2.18885
TMEM131L transmembrane 131 like -2.1876
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 -2.18579
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) -2.18493
TCTN3 tectonic family member 3 -2.1837
GDI2 GDP dissociation inhibitor 2 -2.18287
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -2.18049
ACP6 acid phosphatase 6, lysophosphatidic -2.17437
RSL1D1 ribosomal L1 domain containing 1 -2.17389
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -2.17135
PIGV phosphatidylinositol glycan anchor biosynthesis, class V -2.16418
TMEM39B transmembrane protein 39B -2.1639
GGT5 gamma-glutamyltransferase 5 -2.15878
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -2.1568
ISOC2 isochorismatase domain containing 2 -2.15566
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 -2.15375
OXLD1 oxidoreductase-like domain containing 1 -2.15136
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 -2.14999
FBXO5 F-box protein 5 -2.14678
EIPR1 EARP complex and GARP complex interacting protein 1 -2.13851
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit -2.13846
MCTP2 multiple C2 domains, transmembrane 2 -2.13476
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.12676
TOP2B topoisomerase (DNA) II beta 180kDa -2.12638
DPYD dihydropyrimidine dehydrogenase -2.12619
ARGLU1 arginine and glutamate rich 1 -2.1236
HPR haptoglobin-related protein -2.12144
FAN1 FANCD2/FANCI-associated nuclease 1 -2.12092
NBAS neuroblastoma amplified sequence -2.12038
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.11995
RAN RAN, member RAS oncogene family -2.11724
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.11656
PEX12 peroxisomal biogenesis factor 12 -2.11635
RPL4 ribosomal protein L4 -2.11501
CDK4 cyclin-dependent kinase 4 -2.11028
TMEM168 transmembrane protein 168 -2.10721
KYAT3 kynurenine aminotransferase 3 -2.10586
RAD50 RAD50 homolog (S. cerevisiae) -2.10212
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) -2.10088
NPM3 nucleophosmin/nucleoplasmin 3 -2.0986
FJX1 four jointed box 1 (Drosophila) -2.09754
FXN frataxin -2.09506
C5 complement component 5 -2.09391
TRAPPC11 trafficking protein particle complex 11 -2.09233
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.09194
ZBTB11 zinc finger and BTB domain containing 11 -2.09088
KRCC1 lysine-rich coiled-coil 1 -2.08974
MRPS35 mitochondrial ribosomal protein S35 -2.08968
CLEC10A C-type lectin domain family 10, member A -2.089
XPOT exportin, tRNA -2.08855
FTO fat mass and obesity associated -2.08734
MRPS33 mitochondrial ribosomal protein S33 -2.0872
NOP14 NOP14 nucleolar protein -2.08643
ZNF324B zinc finger protein 324B -2.08634
TSPYL5 TSPY-like 5 -2.08343
TRMT61B tRNA methyltransferase 61B -2.0827
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 -2.08163
RNGTT RNA guanylyltransferase and 5'-phosphatase -2.07995
MAP2K5 mitogen-activated protein kinase kinase 5 -2.07921
UFSP2 UFM1-specific peptidase 2 -2.0765
PDCD2 programmed cell death 2 -2.06823
BORA bora, aurora kinase A activator -2.06791
ACO1 aconitase 1, soluble -2.06726
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 -2.06556
PPA1 pyrophosphatase (inorganic) 1 -2.06544
RBL2 retinoblastoma-like 2 -2.06521
CHD1L chromodomain helicase DNA binding protein 1-like -2.06357
ERCC6L excision repair cross-complementation group 6-like -2.06041
SMYD5 SMYD family member 5 -2.0584
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin -2.05649
ARB2A ARB2 cotranscriptional regulator A -2.05595
PCTP phosphatidylcholine transfer protein -2.0558
NUP42 nucleoporin 42 -2.05428
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -2.05377
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -2.05314
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -2.05163
ANO10 anoctamin 10 -2.05109
LOC128966622 putative protein N-methyltransferase FAM86B2 -2.04939
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.04889
HEMK2 HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine -2.04607
SARS2 seryl-tRNA synthetase 2, mitochondrial -2.04456
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 -2.04449
PTTG1 pituitary tumor-transforming 1 -2.04332
HMGN4 high mobility group nucleosomal binding domain 4 -2.03925
TASOR transcription activation suppressor -2.03632
CCDC102B coiled-coil domain containing 102B -2.03007
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -2.02804
APOLD1 apolipoprotein L domain containing 1 -2.02777
LETMD1 LETM1 domain containing 1 -2.02709
HJURP Holliday junction recognition protein -2.02506
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase -2.02473
PALS2 protein associated with LIN7 2, MAGUK p55 family member -2.02405
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 -2.024
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.01913
LOC124907782 dual specificity protein phosphatase 22 -2.01846
ACY1 aminoacylase 1 -2.01827
ZNF22 zinc finger protein 22 -2.0176
RPUSD2 RNA pseudouridylate synthase domain containing 2 -2.01592
THADA thyroid adenoma associated -2.01222
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.01097
ATRAID all-trans retinoic acid-induced differentiation factor -2.01091
RNF167 ring finger protein 167 -2.01041
ZNF74 zinc finger protein 74 -2.00934
CDK20 cyclin-dependent kinase 20 -2.00675
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -2.00592
PDF peptide deformylase (mitochondrial) -2.00341
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa -2.00332
SNRPE small nuclear ribonucleoprotein polypeptide E -2.00236
ZNF16 zinc finger protein 16 -2.00047