| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | chlorambucil 11.06 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome) |
| Similar Terms | |
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57 genes differentially expressed following the CRCGN016_MCF10A.TP53.M_24H:B24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.23451 |
| BDH1 | 3-hydroxybutyrate dehydrogenase, type 1 | 3.79448 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 3.7589 |
| ICAM3 | intercellular adhesion molecule 3 | 3.48918 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.41511 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 3.39675 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 3.28762 |
| AGR2 | anterior gradient 2 | 3.26003 |
| TCEA2 | transcription elongation factor A (SII), 2 | 3.23685 |
| HSPB1 | heat shock 27kDa protein 1 | 3.03314 |
| MAP7 | microtubule-associated protein 7 | 3.00899 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 2.79116 |
| ZNF586 | zinc finger protein 586 | 2.75034 |
| COMP | cartilage oligomeric matrix protein | 2.6853 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | 2.5771 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.57518 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 2.43108 |
| STAP2 | signal transducing adaptor family member 2 | 2.35184 |
| TICAM1 | toll-like receptor adaptor molecule 1 | 2.34376 |
| PRR15L | proline rich 15-like | 2.26741 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | 2.25764 |
| HMOX1 | heme oxygenase 1 | 2.20576 |
| MSRA | methionine sulfoxide reductase A | 2.05337 |
| BLCAP | bladder cancer associated protein | 2.02842 |
| ABHD4 | abhydrolase domain containing 4 | 2.01729 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | 2.01555 |
| HEBP2 | heme binding protein 2 | 2.01134 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.01024 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PSRC1 | proline/serine-rich coiled-coil 1 | -5.1972 |
| CDC20 | cell division cycle 20 | -4.82928 |
| CCNB2 | cyclin B2 | -4.02483 |
| STX1A | syntaxin 1A (brain) | -3.84707 |
| PLK1 | polo-like kinase 1 | -3.80446 |
| KIF20A | kinesin family member 20A | -3.53528 |
| PMM2 | phosphomannomutase 2 | -3.33995 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -3.28549 |
| PFN1 | profilin 1 | -2.93087 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -2.8859 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -2.84072 |
| NPTXR | neuronal pentraxin receptor | -2.53089 |
| DNM1 | dynamin 1 | -2.46444 |
| RNF167 | ring finger protein 167 | -2.42992 |
| LBR | lamin B receptor | -2.42748 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -2.40756 |
| CACNG3 | calcium channel, voltage-dependent, gamma subunit 3 | -2.34168 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -2.14873 |
| DDN | dendrin | -2.12664 |
| TMEM59L | transmembrane protein 59-like | -2.12185 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | -2.081 |
| CABP1 | calcium binding protein 1 | -2.06615 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | -2.06377 |
| CPAMD8 | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 | -2.0635 |
| ARHGAP11A | Rho GTPase activating protein 11A | -2.04247 |
| COPS7A | COP9 signalosome subunit 7A | -2.04232 |
| SLC17A7 | solute carrier family 17 (vesicular glutamate transporter), member 7 | -2.0407 |
| MGRN1 | mahogunin ring finger 1, E3 ubiquitin protein ligase | -2.01554 |
| KLHDC2 | kelch domain containing 2 | -2.00627 |
